Zobrazeno 1 - 10
of 434
pro vyhledávání: '"Paul A. Morgan"'
Autor:
Fendi Pradana, Tarondeep Nijjar, Phoebe A. Cox, Paul T. Morgan, Tim Podlogar, Samuel J. E. Lucas, Mark T. Drayson, Francesca A. M. Kinsella, Alex J. Wadley
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionPeripheral blood stem cell (PBSC) donation is the primary procedure used to collect hematopoietic stem and progenitor cells (HSPCs) for hematopoietic stem cell transplantation. Single bouts of exercise transiently enrich peripheral blood
Externí odkaz:
https://doaj.org/article/e816c4585b1a4d5697a22e142d5557cc
Autor:
Alastair McCabe, Stewart Martin, Selene Rowe, Jagrit Shah, Paul S. Morgan, Damian Borys, Rafal Panek
Publikováno v:
European Radiology Experimental, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Background Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many
Externí odkaz:
https://doaj.org/article/4cdf90cad616462cb95ae643ce3f064e
Autor:
Sarah Kohe, Christopher Bennett, Florence Burté, Magretta Adiamah, Heather Rose, Lara Worthington, Fatma Scerif, Lesley MacPherson, Simrandip Gill, Debbie Hicks, Edward C. Schwalbe, Stephen Crosier, Lisa Storer, Ambarasu Lourdusamy, Dipyan Mitra, Paul S. Morgan, Robert A. Dineen, Shivaram Avula, Barry Pizer, Martin Wilson, Nigel Davies, Daniel Tennant, Simon Bailey, Daniel Williamson, Theodoros N. Arvanitis, Richard G. Grundy, Steven C. Clifford, Andrew C. Peet
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104958- (2024)
Summary: Background: The malignant childhood brain tumour, medulloblastoma, is classified clinically into molecular groups which guide therapy. DNA-methylation profiling is the current classification ‘gold-standard’, typically delivered 3–4 wee
Externí odkaz:
https://doaj.org/article/7ea57b301d434c53922cf4908ce48606
Autor:
Ryan Neil Marshall, James McKendry, Benoit Smeuninx, Alex Peter Seabright, Paul T. Morgan, Carolyn Greig, Leigh Breen
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Background: Ageing is associated with alterations to skeletal muscle oxidative metabolism that may be influenced by physical activity status, although the mechanisms underlying these changes have not been unraveled. Similarly, the effect of resistanc
Externí odkaz:
https://doaj.org/article/de08f090565e4daba2d56371146d5605
Autor:
Ryan N. Marshall, Benoit Smeuninx, Alex P. Seabright, Paul T. Morgan, Philip J. Atherton, Andrew Philp, Leigh Breen
Publikováno v:
Physiological Reports, Vol 10, Iss 13, Pp n/a-n/a (2022)
Abstract Bed rest (BR) results in significant impairments in skeletal muscle metabolism. Mitochondrial metabolism is reportedly highly sensitive to disuse, with dysregulated fission‐fusion events and impaired oxidative function previously reported.
Externí odkaz:
https://doaj.org/article/3c739f0e2b8a459289b34cd470e6430b
Autor:
Paul T. Morgan, Leigh Breen
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract The protein supplement industry is expanding rapidly and estimated to have a multi-billion market worth. Recent research has centred on understanding how the manufacturing processes of protein supplements may impact muscle recovery and remod
Externí odkaz:
https://doaj.org/article/c1f33cbbeb8c4325a66dcf811ce9b442
Autor:
Benoit Smeuninx, Yasir S. Elhassan, Konstantinos N. Manolopoulos, Elizabeth Sapey, Alison B. Rushton, Sophie J. Edwards, Paul T. Morgan, Andrew Philp, Matthew S. Brook, Nima Gharahdaghi, Kenneth Smith, Philip J. Atherton, Leigh Breen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 1, Pp 52-69 (2021)
Abstract Background Poor recovery from periods of disuse accelerates age‐related muscle loss, predisposing individuals to the development of secondary adverse health outcomes. Exercise prior to disuse (prehabilitation) may prevent muscle deteriorat
Externí odkaz:
https://doaj.org/article/dd767f5982414a148eda2a2db9a28333
Autor:
Richard B. Gillis, Hodaya V. Solomon, Lata Govada, Neil J. Oldham, Vlad Dinu, Shahwar Imran Jiwani, Philemon Gyasi-Antwi, Frank Coffey, Andy Meal, Paul S. Morgan, Stephen E. Harding, John R. Helliwell, Naomi E. Chayen, Gary G. Adams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract This study concerns glulisine, a rapid-acting insulin analogue that plays a fundamental role in diabetes management. We have applied a combination of methods namely X-ray crystallography, and biophysical characterisation to provide a detaile
Externí odkaz:
https://doaj.org/article/1baf07d48a3740889f7ac839d941f0d3
Autor:
Ceri Alan Fielding, Pragati Sabberwal, James C Williamson, Edward JD Greenwood, Thomas WM Crozier, Wioleta Zelek, Jeffrey Seow, Carl Graham, Isabella Huettner, Jonathan D Edgeworth, David A Price, Paul B Morgan, Kristin Ladell, Matthias Eberl, Ian R Humphreys, Blair Merrick, Katie Doores, Sam J Wilson, Paul J Lehner, Eddie CY Wang, Richard J Stanton
Publikováno v:
eLife, Vol 11 (2022)
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion. Understanding this process is key to understanding pathogenesis, genet
Externí odkaz:
https://doaj.org/article/dac3657f8bfc48e98d71a0036c060efa
Autor:
Paul Marcel Morgan
Publikováno v:
International Journal of Medical Students, Vol 7, Iss 2, Pp 45-49 (2019)
Background: While hyperglycemia is intimately associated with uncontrolled diabetes mellitus (DM), recent clinical studies have demonstrated that hyperglycemia is also present in the early acute phase of stroke and is associated with poor prognosis a
Externí odkaz:
https://doaj.org/article/c7addcedef7e46c4816da7ef81530c3f