Zobrazeno 1 - 10
of 821
pro vyhledávání: '"Paul A. Matthews"'
Autor:
Paul A. Matthews, Brigitte E. Scammell, Arfan Ali, Timothy Coughlin, Jessica Nightingale, Tanvir Khan, Ben J. Ollivere
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Following surgical fixation of ankle fractures, the traditional management has included immobilisation for 6 weeks in a below-knee cast. However, this can lead to disuse atrophy of the affected leg and joint stiffness. While early
Externí odkaz:
https://doaj.org/article/b068ea47563648a48257b3f59561a627
Autor:
Fotios Koskeridis, Nurun Fancy, Pei Fang Tan, Devendra Meena, Evangelos Evangelou, Paul Elliott, Dennis Wang, Paul M. Matthews, Abbas Dehghan, Ioanna Tzoulaki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Several cardiovascular traits and diseases co-occur with Alzheimer’s disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic
Externí odkaz:
https://doaj.org/article/b7f6e2bef1bb4252a2be241b198e6687
Autor:
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cader, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathologic
Externí odkaz:
https://doaj.org/article/6d33fcf5b51e487193ad2c53717ad721
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
Sarina Grewal, Elisa Gonçalves de Andrade, Rikke Hahn Kofoed, Paul M. Matthews, Isabelle Aubert, Marie-Ève Tremblay, Sophie V. Morse
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Transcranial focused ultrasound (FUS) has the unique ability to target regions of the brain with high spatial precision, in a minimally invasive manner. Neuromodulation studies have shown that FUS can excite or inhibit neuronal activity, demonstratin
Externí odkaz:
https://doaj.org/article/2211b59acb814fe69975a070f2095cbc
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background Microglial activation contributes to both inflammatory damage and repair in experimental ischemic stroke. However, because of the logistical challenges, there have been few clinical imaging studies directly describing inflammatory
Externí odkaz:
https://doaj.org/article/6b6c5fdb59294c7c981e05cfbe140b55
Autor:
Xavier Montalban, Paul M. Matthews, Alex Simpson, John L. Petrie, Cormac Sammon, Sreeram Ramagopalan, Giulio Disanto, Jens Kuhle
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 3, Pp 302-311 (2023)
Abstract Across its clinical development program, ocrelizumab demonstrated efficacy in improving clinical outcomes in multiple sclerosis, including annualized relapse rates and confirmed disability progression. However, as with any new treatment, it
Externí odkaz:
https://doaj.org/article/08ac64793ae54653927c1160ce2c1112
Autor:
Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen, Paul M. Matthews
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-13 (2022)
Abstract Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulating body of research indicates t
Externí odkaz:
https://doaj.org/article/81c1c0ceb9654d9fb3fc373fa3501b08
Autor:
Catherine M. Francis, Matthias E. Futschik, Jian Huang, Wenjia Bai, Muralidharan Sargurupremraj, Alexander Teumer, Monique M. B. Breteler, Enrico Petretto, Amanda S. R. Ho, Philippe Amouyel, Stefan T. Engelter, Robin Bülow, Uwe Völker, Henry Völzke, Marcus Dörr, Mohammed-Aslam Imtiaz, N. Ahmad Aziz, Valerie Lohner, James S. Ware, Stephanie Debette, Paul Elliott, Abbas Dehghan, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Aortic distensibility is a risk factor for multiple cardiovascular events, but the genetic etiology is not well understood. Here, the authors identify genetic variants linked to aortic distensibility, highlighting mechanistic pathways and causal rela
Externí odkaz:
https://doaj.org/article/a5d0caf9381c40529e225078de909c70
Autor:
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Externí odkaz:
https://doaj.org/article/3684566e972d48bda37be69378c00e42