Výsledky vyhledávání - "Paul A. Konowicz"

Assessment of in vivo degradation profiles of hyaluronic acid hydrogels using temporal evolution of chemical exchange saturation transfer (CEST) MRI

Autor: Robert Fogle, Dinesh S. Bangari, Rubina Corazzini, Jennifer Johnson, Xiaoyou Ying, Pradeep Dhal, Paul A. Konowicz, Mohammed Salman Shazeeb

Publikováno v: Biomaterials. 178

Hyaluronic acid (HA) hydrogels have found a wide range of applications in biomedicine: regenerative medicine to drug delivery applications . In vivo quantitative assessment of these hydrogels using magnetic resonance imaging (MRI) provides an effecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a15ce3eea0937a96aaf490ef26fdb2d
https://pubmed.ncbi.nlm.nih.gov/29861090

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Process Development of a GCS Inhibitor Including Demonstration of Lossen Rearrangement on Kilogram Scale

Autor: Michael R. Reardon, Edward R. Lee, Vitaly Nivorozhkin, Lynne Sole, Jin Zhao, Craig Siegel, Sanjeev S. Katti, Paul A. Konowicz, Rayomand H. Gimi, Jerome Green

Publikováno v: Organic Process Research & Development. 19:576-581

A small molecule was under investigation as an inhibitor of glucosylceramide synthase (GCS) for potential use in Fabry disease. To support preclinical activities, a four-step synthesis was developed and used to prepared kilogram quantities of the dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bcc128919c579eda4090ec1d13b603c
https://doi.org/10.1021/op500379a

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Glycan Structure Determinants for Cation-Independent Mannose 6-Phosphate Receptor Binding and Cellular Uptake of a Recombinant Protein

Autor: Xiaoyang Zheng, Patrick Finn, Robert J. Miller, Elizabeth Brunyak, Clark Pan, Josephine Kyazike, Michael R. Reardon, John Harrahy, Luis Z. Avila, Qun Zhou, Scott M. Van Patten, Jennifer Kim, Paul A. Konowicz

Publikováno v: Bioconjugate Chemistry. 24:2025-2035

The cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in intracellular transport of lysosomal enzymes as well as the uptake of recombinant proteins. To define the minimal glycan structure determinants necessary for recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d22558b36c4beaac56f9208166d6ae7
https://doi.org/10.1021/bc400365a

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Enzymatic regioselective deprotection of peracetylated mono- and disaccharides

Autor: Paul A. Konowicz, Riaz A. Khan, Line Gropen, Lucia Gardossi, Berit Smestad Paulsen

Publikováno v: Journal of Molecular Catalysis B: Enzymatic. 6:89-94

Selective enzymatic hydrolysis of the peracetylated disaccharides, namely cellobiose, lactose, maltose and melibiose, with lipase from Asperilligus niger in aqueous buffer and organic solvent for 30 min afforded exclusively the corresponding heptaace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779a9585c2411b63b74715d28a651037
https://doi.org/10.1016/s1381-1177(98)00130-1

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Selective acetylation reactions of hyaluronic acid benzyl ester derivative

Autor: Paolo Linda, Sergio Paoletti, Paul A. Konowicz, Riaz A. Khan, Regina Vesnaver, Juraj Bella

Publikováno v: Carbohydrate Research. 306:137-146

The reaction of hyaluronic acid benzyl ester derivative (1) with trimethyl orthoacetate in the presence of an acid catalyst in N,N-dimethylformamide gave the expected 4,6-orthoester 2, along with its hydrolysed products the 6-O- (3) and the 4-O- (4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b8ef7841b90d232d44933826d770d3
https://doi.org/10.1016/s0008-6215(97)10057-x

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Synthesis of 6-deoxy-6-halolaminarans and conversion of 6-chloro-6-deoxylaminaran into the 6-amino-6-deoxy derivative

Autor: Marco Bosco, Roberto Rizzo, Luca Stucchi, Paul A. Konowicz, Riaz A. Khan

Publikováno v: Carbohydrate Research. 292:39-46

The reaction of laminaran, a linear polyglucan with β -(1 → 3)-linkages 1 , with trityl chloride followed by conventional acetylation gave a product that contained predominantly 6- O -trityl-2,4-di- O -acetate ( 3 ). Detritylation using hot aqueou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eb9c7ce9c19a64066500b579932ea83
https://doi.org/10.1016/s0008-6215(96)91021-6

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Drug Delivery and Medical Applications of Chemically Modified Hyaluronan

Autor: Luis Z. Avila, Diego A. Gianolio, Robert J. Miller, C. Michael Philbrook, Michael Santos, Paul A. Konowicz

Publisher Summary Hyaluronan (HA) is a linear naturally occurring polyanionic polysaccharide that is ubiquitous in nature and is produced virtually by every tissue in higher organisms and some bacteria. HA has excellent biocompatibility and is readil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fc8788c4af4696a9858df95f96bd8c3
https://doi.org/10.1016/b978-0-08-054816-6.00015-x

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Sucrose octabenzoate: assignment of13C and1H resonances of the sucrose moiety and the13C resonances of the carbonyl carbons. Use of13C-n.m.r. spectroscopy for the study of selective deacylation

Autor: Haydn F. Jones, Paul A. Konowicz, Alan H. Haines, Ian J. Colquhoun

Publikováno v: Carbohydrate Research. 205:53-59

Assignment of the1H and13C signals arising from the carbohydrate portion of sucrose octabenzoate has been achieved using homonuclear shift correlation experiments (COSY) and one-bond1H-13C heteronuclear shift correlation measurements, respectively. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969f9f694da399e253a5c63aa6a59c21
https://doi.org/10.1016/0008-6215(90)80127-o

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