Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Paul A. Kitos"'
Publikováno v:
Analytical Biochemistry. 336:187-195
A reliable, indirect method (GPD/INT assay) for estimating the number of live animal cells in multiwell culture has been devised. It is based on the glucose-6-phosphate dehydrogenase (Gpdh) and 6-phosphogluconate dehydrogenase activities present in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe5ebea58a3de4ee14371dd6b896458
https://doi.org/10.1016/j.ab.2004.10.008
https://doi.org/10.1016/j.ab.2004.10.008
Publikováno v:
Cytotechnology. 32:63-75
A method is described for estimating the numbers ofanimal cells in multi-well culture by simultaneouslymeasuring the lactate dehydrogenase activity of thetotal culture and the medium. The difference betweenthe two reflects the dehydrogenase content o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e11b6bbcd8915a151bba4a604031f33
https://doi.org/10.1023/a:1008121125755
https://doi.org/10.1023/a:1008121125755
Autor:
Ariane E. Marolewski, Paul A. Kitos, Dale L. Boger, Joseph Ramcharan, Nancy-Ellen Haynes, Mark S. Warren, Stephen J. Benkovic
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1817-1830
The synthesis of 10-formyl-5,8,10-trideazafolic acid (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) is reported. The target compound was prepared by a convergent synthesis utilizing the alkylation of hydrazone 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801564b7c66ebceeb7b44a19dcdf6271
https://doi.org/10.1016/s0968-0896(97)00120-x
https://doi.org/10.1016/s0968-0896(97)00120-x
Autor:
Joseph Ramcharan, Stephen J. Benkovic, Mark S. Warren, Paul A. Kitos, Lata T. Gooljarsingh, Nancy-Ellen Haynes, Dale L. Boger
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1831-1838
A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deb241e33a823c08832a2cc74b8f04d
https://doi.org/10.1016/s0968-0896(97)00121-1
https://doi.org/10.1016/s0968-0896(97)00121-1
Autor:
Mark S. Warren, Joseph Ramcharan, Nancy-Ellen Haynes, Paul A. Kitos, Dale L. Boger, Stephen J. Benkovic
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1839-1846
A set of inhibitors 3 and 4 of GAR and AICAR Tfase based on the TDAF core which contain an sp2 C-10 carbon atom replacing N-10 of the natural cofactor are detailed. Both possess electrophilic olefins and the potential of trapping the reacting amine o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8fa69c92d9bd85787eeb3715cbe9fe
https://doi.org/10.1016/s0968-0896(97)00122-3
https://doi.org/10.1016/s0968-0896(97)00122-3
Autor:
Bernd Bollinger, Dale L. Boger, Qing Jin, Donald L. Hertzog, Paul A. Kitos, Hui Cai, Douglas S. Johnson, Robert M. Garbaccio, Philippe Mesini
Publikováno v:
Journal of the American Chemical Society. 119:4987-4998
The synthesis and examination of two unique classes of duocarmycin SA analogs are described which we refer to as reversed and sandwiched analogs. Their examination established both the origin of the DNA alkylation selectivity and that both enantiomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca118822aed4c348debe4ee4a6424ca5
https://doi.org/10.1021/ja9637210
https://doi.org/10.1021/ja9637210
Autor:
Dale L. Boger, Christine M. Tarby, Paul A. Kitos, Jeffrey A. McKie, Nianhe Han, Haiqiong W. Riggs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:659-664
A quantitative Hammett study of the magnitude of the electronic effects of a C7 substituent on the functional reactivity of N-BOC-CBI (5, RH), its impact on biological properties, details of the mechanism of the acid-catalyzed nucleophilic additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438ebf48cfe7f37bcce13ccd9aeba166
https://doi.org/10.1016/0960-894x(96)00093-5
https://doi.org/10.1016/0960-894x(96)00093-5
Publikováno v:
Journal of the American Chemical Society. 115:9025-9036
Concise total syntheses of natural (+)- and ent-(-)-duocarmycin SA (1) are detailed based on sequential regioselective nucleophilic substitution reactions of the unsymmetrical p-quinone diimine 3 in the preparation of a dihydropyrroloindole precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b48e1ebe3c87410e56b50960aa4cd6
https://doi.org/10.1021/ja00073a019
https://doi.org/10.1021/ja00073a019
Autor:
Dale L. Boger, Douglas S. Johnson, Jiyoung Chang, Paul A. Kitos, Moorthy S. S. Palanki, Paul Dowell
Publikováno v:
Bioorganic & Medicinal Chemistry. 1:27-38
The DNA alkylation properties and in vitro cytotoxic activity of a series of analogs of CC-1065 and the duocarmycins incorporating the 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[ c ]benz[ e ]inol-4-one (C 2 BI) alkylation subunit are detailed. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a0efb1313c870e8ce4d877927dca6f
https://doi.org/10.1016/s0968-0896(00)82100-8
https://doi.org/10.1016/s0968-0896(00)82100-8
Publikováno v:
Thrombosis and Haemostasis. 69:119-123
SummaryProtease nexin 1 (PN1), a serine protease inhibitor that inactivates thrombin, urokinase, and plasmin, is produced abundantly in cultures of human fibroblasts and rat and human glioma cells. The major sites of PN1 synthesis in vivo and the spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055993398d4920d1ab5c5bca105c1583
https://doi.org/10.1055/s-0038-1651566
https://doi.org/10.1055/s-0038-1651566