Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paul A. Kirchman"'
Autor:
Paul A. Kirchman, Nicholas Van Zee
Publikováno v:
Canadian journal of microbiology. 63(9)
Individual cells of the budding yeast Saccharomyces cerevisiae have a limited replicative potential, referred to as the replicative lifespan. We have found that both the growth rate and average replicative lifespan of S. cerevisiae cells are greatly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882bf0f5172c5ace0310b2666db25274
https://pubmed.ncbi.nlm.nih.gov/28679065
https://pubmed.ncbi.nlm.nih.gov/28679065
Autor:
Gabriela Botta, Paul A. Kirchman
Publikováno v:
Mechanisms of Ageing and Development. 128:187-195
To further exploit yeast as a model for cellular aging we have modified the replicative life span assay to force respiration, by replacing glucose with the non-fermentable carbon source glycerol. The growth rates of several different strains varied g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c318e780b32e3d8bf54c1888605b2f6d
https://doi.org/10.1016/j.mad.2006.10.003
https://doi.org/10.1016/j.mad.2006.10.003
Publikováno v:
Experimental Gerontology. 39:999-1009
Individual yeast cells display a finite replicative capacity. LAG1 was identified as a gene that is differentially expressed during the yeast replicative life span and was shown to play a role in determining yeast longevity. This gene is not essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc29c52bc0b4f7eb6c775c75cd7e329
https://doi.org/10.1016/j.exger.2004.03.026
https://doi.org/10.1016/j.exger.2004.03.026
Autor:
S. Michal Jazwinski, Paul A. Kirchman, Sangkyu Kim, Roger L West, Michael V. Miceli, James C. Jiang
Publikováno v:
Acta Biochimica Polonica. 50:1039-1056
The yeast Saccharomyces cerevisiae has a finite replicative life span. Yeasts possess two prohibitins, Phb1p and Phb2p, in similarity to mammalian cells. These proteins are located in the inner mitochondrial membrane, where they are involved in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd9463d3d1a9825b902e37c604fd657
https://doi.org/10.18388/abp.2003_3630
https://doi.org/10.18388/abp.2003_3630
Publikováno v:
Genetics. 152:179-190
Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69bf6f981317dc440b4bd6541c1a40c
https://doi.org/10.1093/genetics/152.1.179
https://doi.org/10.1093/genetics/152.1.179
Publikováno v:
Genome Research. 8:1259-1272
LAG1 is a longevity gene, the first such gene to be identified and cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, which we call LAC1, has been found in the yeast genome. We have cloned the human homolog ofLAG1 with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e215f41ec5a515584b9881251dce56
https://doi.org/10.1101/gr.8.12.1259
https://doi.org/10.1101/gr.8.12.1259
Publikováno v:
Experimental gerontology. 46(10)
We have previously shown that copper supplementation extends the replicative life span of Saccharomyces cerevisiae when grown under conditions forcing cells to respire. We now show that copper's effect on life span is through Fet3p, a copper containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c796d5157da7c7ddae1b536d0a0500
https://pubmed.ncbi.nlm.nih.gov/21798334
https://pubmed.ncbi.nlm.nih.gov/21798334
Publikováno v:
Proceedings of the National Academy of Sciences. 88:4533-4537
Examination of the effects of 56 single-base-pair substitutions in the spoIIG promoter and studies of the interaction of the spo0A product (Spo0A) with this promoter in vitro demonstrated that Spo0A acts directly to enable this promoter to be used by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ccc3303eddc494b3268baa016a2ee
https://doi.org/10.1073/pnas.88.10.4533
https://doi.org/10.1073/pnas.88.10.4533
Autor:
Paul A, Kirchman, Michael V, Miceli, Roger L, West, James C, Jiang, Sangkyu, Kim, S Michal, Jazwinski
Publikováno v:
Acta biochimica Polonica. 50(4)
The yeast Saccharomyces cerevisiae has a finite replicative life span. Yeasts possess two prohibitins, Phb1p and Phb2p, in similarity to mammalian cells. These proteins are located in the inner mitochondrial membrane, where they are involved in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee14b854182ab3aef3f6f8b26d5fcccb
https://pubmed.ncbi.nlm.nih.gov/14739993
https://pubmed.ncbi.nlm.nih.gov/14739993
Autor:
Martine Pfefferli, Rachel Chuard, Andreas Conzelmann, Isabelle Guillas, S. Michal Jazwinski, James C. Jiang, Paul A. Kirchman
Lag1p and Lac1p are two highly homologous membrane proteins of the endoplasmic reticulum (ER). When both genes are deleted, cells cannot transport glycosylphosphatidylinositol (GPI)-anchored proteins from the ER to the Golgi at a normal rate. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc1e10091137b2bd526d68189aef423
https://europepmc.org/articles/PMC125493/
https://europepmc.org/articles/PMC125493/
