Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Paul A. Heppenstall"'
Autor:
Timo A. Nees, Na Wang, Pavel Adamek, Nadja Zeitzschel, Clement Verkest, Carmen La Porta, Irina Schaefer, Julie Virnich, Selin Balkaya, Vincenzo Prato, Chiara Morelli, Valerie Begay, Young Jae Lee, Anke Tappe-Theodor, Gary R. Lewin, Paul A. Heppenstall, Francisco J. Taberner, Stefan G. Lechner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity
Externí odkaz:
https://doaj.org/article/ad36199c53bf4668bb1d766ff2c256d7
Autor:
Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J. Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G. Lechner, Paul A. Heppenstall
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and
Externí odkaz:
https://doaj.org/article/fe4dc2a3ccaf4f5496713ff8538a5861
Autor:
Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, Stefan G. Lechner
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3102-3115 (2017)
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described
Externí odkaz:
https://doaj.org/article/de82496017424d9f95bdaa393f2d5efc
Autor:
Laura Batti, Mayya Sundukova, Emanuele Murana, Sofia Pimpinella, Fernanda De Castro Reis, Francesca Pagani, Hong Wang, Eloisa Pellegrino, Emerald Perlas, Silvia Di Angelantonio, Davide Ragozzino, Paul A. Heppenstall
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2608-2615 (2016)
Neuropathic pain is a widespread chronic pain state that results from injury to the nervous system. Spinal microglia play a causative role in the pathogenesis of neuropathic pain through secretion of growth factors and cytokines. Here, we investigate
Externí odkaz:
https://doaj.org/article/1d1b0263c2c847a8acf2da728efd01e5
Autor:
Liudmila Lapatsina, Julia A. Jira, Ewan St. J. Smith, Kate Poole, Alexey Kozlenkov, Daniel Bilbao, Gary R. Lewin, Paul A. Heppenstall
Publikováno v:
Open Biology, Vol 2, Iss 6 (2012)
A complex of stomatin-family proteins and acid-sensing (proton-gated) ion channel (ASIC) family members participate in sensory transduction in invertebrates and vertebrates. Here, we have examined the role of the stomatin-family protein stomatin-like
Externí odkaz:
https://doaj.org/article/cbc394439d1846f8b50a04554ac201ae
Autor:
Christopher Sliwinski, Laura Heutehaus, Francisco J. Taberner, Lisa Weiss, Vasileios Kampanis, Bahardokht Tolou-Dabbaghian, Xing Cheng, Melanie Motsch, Paul A. Heppenstall, Rohini Kuner, Steffen Franz, Stefan G. Lechner, Norbert Weidner, Radhika Puttagunta
Evidence from previous studies supports the concept that spinal cord injury (SCI) induced neuropathic pain (NP) has its neural roots in the peripheral nervous system. There is uncertainty about how and to which degree nociceptors and mechanoreceptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a62e0c0ae9a9a4e967efd356db042ec
https://doi.org/10.1101/2022.12.18.520950
https://doi.org/10.1101/2022.12.18.520950
Autor:
Timo A. Nees, Na Wang, Pavel Adamek, Clement Verkest, Carmen La Porta, Irina Schaefer, Julie Virnich, Selin Balkaya, Vincenzo Prato, Chiara Morelli, Nadja Zeitzschel, Valerie Begay, Young Jae Lee, Anke Tappe-Theodor, Gary R. Lewin, Paul A. Heppenstall, Francisco J. Taberner, Stefan G. Lechner
SummarySilent nociceptors are sensory afferents that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli during inflammation. Using RNA-sequencing and quantitative RT-PCR we demonstrate that inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89460af4310a8b91006c729c3bee9b82
https://doi.org/10.1101/2022.04.07.486730
https://doi.org/10.1101/2022.04.07.486730
Publikováno v:
Cell reports. 38(3)
In their Matters Arising article, McMullan et al. (2022) offer alternative explanations for the phenotypes we observed upon stimulation and ablation of TrkC
Autor:
Florian Kampmeier, Paul A. Heppenstall, Ivo Meinhold-Heerlein, Stefan Barth, Ahmad Fawzi Hussain
Publikováno v:
Nature Protocols. 14:3101-3125
Antibody-based diagnostic and therapeutic agents play a substantial role in medicine, especially in cancer management. A variety of chemical, genetic and enzymatic site-specific conjugation methods have been developed for equipping antibodies with ef
Autor:
Paul A. Heppenstall, Irina Schaefer, Vincenzo Prato, Stefan G. Lechner, Francisco J. Taberner, Katrin Schrenk-Siemens
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Aristotle’s five senses—sight, smell, taste, hearing, and touch—are crucial for the perception of and interaction with the environment. While the molecular machineries that detect visual, olfactory, gustatory, and auditory stimuli