Double-Masked, Vehicle-Controlled, Randomized, Phase II Study of the Ocular Hypotensive Activity and Safety of VVN539 Ophthalmic Solution

Autor: David Wirta, MD, Xiao-Yan Li, MD, Wang Shen, PhD, Caroline Lu, MS, Gary D. Novack, PhD, William Christie, MD, Paul J. Hartman, MD, Lawrence Tafoya, MD, PhD, Navin Tekwani, MD

Publikováno v: Ophthalmology Science, Vol 4, Iss 2, Pp 100426- (2024)

Purpose: To assess safety and ocular hypotensive efficacy of VVN539 ophthalmic solution in a first-in-human study. Design: Multicenter, double-masked, randomized, vehicle-controlled, dose-response, parallel-comparison study. Participants: Sixty-eight

Externí odkaz: https://doaj.org/article/dd843ed5dee24a18aff6fd4d9405beb5

Phentolamine Mesylate Ophthalmic Solution Provides Lasting Pupil Modulation and Improves Near Visual Acuity in Presbyopic Glaucoma Patients in a Randomized Phase 2b Clinical Trial

Autor: Charles B. Slonim, Mina Sooch, Paul M. Karpecki, Eliot Lazar, Seth A Klapman, Robert Smyth-Medina, Alan R. Meyer, Jonah E Yousif, Harvey B DuBiner, Reda M Jaber, Paul J Hartman, Arin T Amin, Sayoko E Moroi, Marc A. Abrams, Jay S. Pepose, Marguerite B. McDonald, Konstantinos Charizanis

Publikováno v: Clinical Ophthalmology (Auckland, N.Z.)

Jay S Pepose,1,2 Paul J Hartman,3 Harvey B DuBiner,4 Marc A Abrams,5 Robert J Smyth-Medina,6 Sayoko E Moroi,7 Alan R Meyer,8 Mina P Sooch,8 Reda M Jaber,8 Konstantinos Charizanis,8 Seth A Klapman,8 Arin T Amin,8 Jonah E Yousif,8 Eliot S Lazar,9 Paul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a4dbe20ca73c583eeda56698306225
http://europepmc.org/articles/PMC7802916

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1)

Autor: Felipe A. Medeiros, Thomas R. Walters, Miriam Kolko, Michael Coote, Marina Bejanian, Margot L. Goodkin, Qiang Guo, Jane Zhang, Michael R. Robinson, Robert N. Weinreb, Ashish Agar, Renuka Bathijia, Lance Liu, Tim Roberts, Christoph Faschinger, Clemens Vass, Nathalie Collignon, Ana Claudia Alves Pereira, Rubens Belfort de Mattos, Fernando Justino Dantas, Marcelo Jordao Lopes da Silva, Fabio Kanadani, Leopoldo Magacho dos Santos Silva, Tiago Prata, Daniella Bach-Holm, Jimmy Lai, Clement Tham, György Bátor, Lajos Szalczer, Balázs Varsányi, Eytan Blumenthal, Orna Geyer, Shmuel Lavartovsky, Tamar Pedut-Kloizman, Nir Shoham-Hazon, Silvio Lujan, Benjamin Abela, Robert E. Ang, Edgar U. Leuenberger, Harvey Uy, Maria Imelda Yap-Veloso, Piotr Fryczkowski, Piotr Jurowski, Bartlomiej Kalużny, Józef Kalużny, Marta Misiuk-Hojlo, Krystyna Raczynska, Wioletta Tomczyk-Dorozynska, Jaromir Wasyluk, Slawomir Zalewski, Tomasz Zarnowski, Julian Garcia Feijoó, Rafael Giménez-Gómez, Elena Milla Griño, Alfonso Antón López, Merce Guarro Miralles, Javier Montero Moreno, Vicente Polo, Enrique Cervera Taulet, Beatriz Ponte Zúñiga, Ying-Ying Chen, Yuan-Chieh Lee, Louis Alpern, Michael S. Berlin, Jacob Brubaker, Delmar Caldwell, Andrew Camp, Louis B. Cantor, Ronald Caronia, Charles J. Crane, Douglas Day, Eran Duzman, John Elfervig, Sherif El-Harazi, Richard Evans, Ann C. Fisher, William John Flynn, Charles Stephen Foster, Ronald Frenkel, Raj Goyal, Ronald Gross, Paul J. Hartman, William L. Haynes, Gary Jerkins, Janet Kim, Max Kim, Bradley Kwapiszeski, Benjamin Lambright, Christine Larsen, James Lehmann, Jeffrey H. Levenson, Dwayne Logan, Brian McMillan, Joseph R. Martel, Hylton Mayer, Felipe Medeiros, Sayoko Moroi, Andrew Moyes, Jonathan Myers, John Nairn, Steven Nielsen, Don Perez Ortiz, James Paauw, Vicky Pai, Joseph Panarelli, Abraham Park, Mujtaba A. Qazi, Nikola Ragusa, Douglas J. Rhee, Robert Rothman, Reginald Sampson, Samuel Seltzer, Anurag Shrivastava, Steven T. Simmons, Annette Sims, Mark A. Slabaugh, Scott Smetana, Oluwatosin Smith, Scott C. So, Ingeborg Stalmans, Jitendra Swarup, Jay Wallshein, Fiaz Zaman, Rui Zhang

Publikováno v: Medeiros, F A, Walters, T R, Kolko, M, Coote, M, Bejanian, M, Goodkin, M L, Guo, Q, Zhang, J, Robinson, M R, Weinreb, R N, ARTEMIS 1 Study Group, Agar, A, Coote, M, Bathijia, R, Bach-Holm, D, Walters, T R, Zaman, F & Zhang, R 2020, ' Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1) ', Ophthalmology, vol. 127, no. 12, pp. 1627-1641 . https://doi.org/10.1016/j.ophtha.2020.06.018

Purpose To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. Design Randomiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6460ae378d48f231ab7646dd34d2e2a
https://pubmed.ncbi.nlm.nih.gov/32544560

Nearshoring, reshoring, and insourcing: Moving beyond the total cost of ownership conversation

Autor: Joseph R. Wirthlin, Jeffrey A. Ogden, Paul L. Hartman, Benjamin T. Hazen

Publikováno v: Business Horizons. 60:363-373

As firms from across all manufacturing sectors are rethinking their outsourcing and offshoring strategies, there is the potential for a manufacturing renaissance in the U.S. The findings from this case study suggest that the current manufacturing rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edf20e243908b6f29861f9e20d395d70
https://doi.org/10.1016/j.bushor.2017.01.008

Bactericidal and Bacteriolytic Effects of Selected Food-Grade Phosphates, Using Staphylococcus aureus as a Model System

Autor: Fred D. Williams, Ruby M. Lee, Dennis G. Olson, Paul A. Hartman

Publikováno v: Journal of food protection. 57(4)

Phosphates have been approved for use in meat products primarily to protect flavor and increase yields. It also is known that phosphates have antimicrobial properties. The objective of this study was to compare the effects of different phosphates in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee11aad875c0cc15caeff41481555615
https://pubmed.ncbi.nlm.nih.gov/31113135