Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paul A. Dutchak"'
Autor:
Mari Carmen Pelaez, Antoine Desmeules, Pauline A. Gelon, Bastien Glasson, Laetitia Marcadet, Alicia Rodgers, Daniel Phaneuf, Silvia Pozzi, Paul A. Dutchak, Jean-Pierre Julien, Chantelle F. Sephton
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative diseases that belong to a common disease spectrum based on overlapping clinical, pathological and genetic evidence. Early pathological change
Externí odkaz:
https://doaj.org/article/7607d7cbde0a4784a3e433fdc4157ae9
Autor:
Maéline Muller, Jasmine Bélanger, Imane Hadj-Aissa, Conghao Zhang, Chantelle F. Sephton, Paul A. Dutchak
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2068 (2024)
GATOR1 (GAP Activity TOward Rag 1) is an evolutionarily conserved GTPase-activating protein complex that controls the activity of mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid availability in cells. Genetic mutations in t
Externí odkaz:
https://doaj.org/article/3c25a65ef5bb4fe7aef7bfc68190b44d
Autor:
Gaël Nicolas, Myriam Sévigny, François Lecoquierre, Florent Marguet, Andréanne Deschênes, Maria Carment del Pelaez, Sébastien Feuillette, Anaïs Audebrand, Magalie Lecourtois, Stéphane Rousseau, Anne-Claire Richard, Kévin Cassinari, Vincent Deramecourt, Charles Duyckaerts, Anne Boland, Jean-François Deleuze, Vincent Meyer, Jordi Clarimon Echavarria, Ellen Gelpi, Haruhiko Akiyama, Masato Hasegawa, Ito Kawakami, Tsz H. Wong, Jeroen G. J. Van Rooij, John C. Van Swieten, Dominique Campion, Paul A. Dutchak, David Wallon, Flavie Lavoie-Cardinal, Annie Laquerrière, Anne Rovelet-Lecrux, Chantelle F. Sephton
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Frontotemporal dementia (FTD) is a heterogeneous clinical disorder characterized by progressive abnormalities in behavior, executive functions, personality, language and/or motricity. A neuropathological subtype of FTD, frontotemporal lobar
Externí odkaz:
https://doaj.org/article/48e521d609984a38b72e92aa11f8c79b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Synaptic loss is a pathological feature of all neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of the cortical and spinal motor neurons resulting in fatal paralysis due to d
Externí odkaz:
https://doaj.org/article/0ac74559071c4373822be26e63358b9a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Advancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pat
Externí odkaz:
https://doaj.org/article/ba3ebb0bbf534b0a95eff8daac1c45c0
Autor:
Paul A. Dutchak, Sunil Laxman, Sandi Jo Estill, Chensu Wang, Yun Wang, Yiguang Wang, Gamze B. Bulut, Jinming Gao, Lily J. Huang, Benjamin P. Tu
Publikováno v:
Cell Reports, Vol 12, Iss 3, Pp 371-379 (2015)
Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid insufficiency. Here, we show that NPRL2 is required for mouse viability and that
Externí odkaz:
https://doaj.org/article/e6a38e82828d4c96b42c9a03c9f13bc8
Autor:
Geetika Aggarwal, Subhashis Banerjee, Spencer A. Jones, Monica Pavlack, Yousri Benchaar, Jasmine Bélanger, Myriam Sévigny, Denise M. Smith, Michael L. Niehoff, Ian Mitchelle S. de Vera, Terri L. Petkau, Blair R. Leavitt, Karen Ling, Paymaan Jafar‐nejad, Frank Rigo, John E. Morley, Susan A. Farr, Paul A. Dutchak, Chantelle F. Sephton, Andrew D. Nguyen
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Chantelle F. Sephton, Paul A. Dutchak, Janani Priya Venkatasubramani, Myriam Sévigny, Isabelle Bourdeau Julien, Jeremy B. Hui
Publikováno v:
The Journal of Biological Chemistry
The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-binding protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA regulation, including mRNA translation. The mechanism by which FUS affe
Autor:
Geetika Aggarwal, Subhashis Banerjee, Spencer A. Jones, Yousri Benchaar, Jasmine Bélanger, Myriam Sévigny, Denise M. Smith, Michael L. Niehoff, Monica Pavlack, Ian Mitchelle S. de Vera, Terri L. Petkau, Blair R. Leavitt, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, John E. Morley, Susan A. Farr, Paul A. Dutchak, Chantelle F. Sephton, Andrew D. Nguyen
Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several microRNAs, including miR-29b, negatively regulate progranulin protein level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7b8da68ee02f3d4e75571627443102d
https://doi.org/10.1101/2022.01.12.476053
https://doi.org/10.1101/2022.01.12.476053
Autor:
Jeremy B. Hui, Jose Cesar Hernandez Silva, Mari Carmen Pelaez, Myriam Sévigny, Janani Priya Venkatasubramani, Quentin Plumereau, Mohamed Chahine, Christophe D. Proulx, Chantelle F. Sephton, Paul A. Dutchak
Publikováno v:
eNeuro. 9(2)
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (SUDEP), but the mechanisms by which NPRL2 contributes to these effect