Zobrazeno 1 - 10
of 952
pro vyhledávání: '"Paul A. Davies"'
Autor:
Paul A. Davies, Hayley J. Fowler, Roberto Villalobos Herrera, Julia Slingo, David L.A. Flack, Mateusz Taszarek
Publikováno v:
Weather and Climate Extremes, Vol 45, Iss , Pp 100696- (2024)
The motivation of our study is to provide forecasters and users complementary guidance and tools to identify and predict atmospheric conditions that could lead to life-threatening flash floods. Using hourly and sub-hourly rainfall datasets, proximity
Externí odkaz:
https://doaj.org/article/c75b8d58fa134098bedc2aa9aae9a5f1
Autor:
Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109512- (2024)
Summary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is u
Externí odkaz:
https://doaj.org/article/fe648812ed2245d28cd51d531ae0f3c3
Autor:
Joshua L. Smalley, Noell Cho, Shu Fun Josephine Ng, Catherine Choi, Abigail H. S. Lemons, Saad Chaudry, Christopher E. Bope, Jake S. Dengler, Chuansheng Zhang, Matthew N. Rasband, Paul A. Davies, Stephen J. Moss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The subunit composition of GABAA receptors and their interaction with beta spectrin complexes influences their localization between the neuronal axon initial segment or dendrites.
Externí odkaz:
https://doaj.org/article/edfc1bb22db642f7ab73e66911075353
Autor:
Catherine Choi, Joshua L. Smalley, Abigail H. S. Lemons, Qiu Ren, Christopher E. Bope, Jake S. Dengler, Paul A. Davies, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Impaired inhibitory signaling underlies the pathophysiology of many neuropsychiatric and neurodevelopmental disorders including autism spectrum disorders and epilepsy. Neuronal inhibition is regulated by synaptic and extrasynaptic γ-aminobutyric aci
Externí odkaz:
https://doaj.org/article/b30ccc0be6cc46cfb9340dd34a6deb46
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic actions, that reflect in part their efficacy as GABAAR positive allosteric modulators (PAM). In addition to this, NAS exert metabotropic effects on GABAergic i
Externí odkaz:
https://doaj.org/article/1110699bf1494006862b88d33b2130ba
Autor:
Joshua L. Smalley, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purifi
Externí odkaz:
https://doaj.org/article/baaab0297501451c838881430fb7712c
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons and is thus a critical site in the regulation of neuronal excitability. Normal function within the discrete AIS compartment requires intricate molecular ma
Externí odkaz:
https://doaj.org/article/3ae1d090d9a84b1c9ef4e7081360f9b7
Autor:
Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 670-681.e8 (2019)
Summary: The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1-3), β(1-3), and γ2 subunits, and
Externí odkaz:
https://doaj.org/article/21aef49f490e40c29d479eb0c499b258
Autor:
Amit Modgil, Thuy N. Vien, Michael A. Ackley, James J. Doherty, Stephen J. Moss, Paul A. Davies
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS. Neuroactive stero
Externí odkaz:
https://doaj.org/article/6dc66653188e4deb9833a7bba74d2f08
Autor:
Dian-Shi Wang, Agnieszka A. Zurek, Irene Lecker, Jieying Yu, Armen M. Abramian, Sinziana Avramescu, Paul A. Davies, Stephen J. Moss, Wei-Yang Lu, Beverley A. Orser
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 488-496 (2012)
Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse memory deficits by pharmacologic
Externí odkaz:
https://doaj.org/article/1ebcc842bc7d408ba3898da64e571c56