Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Paul A. Cossum"'
Autor:
Jose R. Rodriguez, John H. Rex, Luis Ostrosky-Zeichner, Paul A. Cossum, Enuo Chen, Victor L. Paetznick, T. O. M. Wallace, Scott A. Bazemore
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:2781-2786
When nystatin is placed in RPMI and other biological fluids, there is loss of pure nystatin, with the development of two distinguishable chromatographic peaks, 1 and 2. Peak 1 appears identical to commercially prepared nystatin. By nuclear magnetic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b1f50e85700348652a54d10873c92e
https://doi.org/10.1128/aac.45.10.2781-2786.2001
https://doi.org/10.1128/aac.45.10.2781-2786.2001
Autor:
C. A. Stein, Joshua Ojwang, Irina V. Lebedeva, Robert R. Rando, Anthony J. Raffo, Paul A. Cossum
Publikováno v:
Journal of Urology. 166:461-469
Purpose: We investigated antisense inhibition of anti-apoptotic bcl-xL and bcl-2 proteins to increase chemosensitization in the T24 and 5637 bladder carcinoma cell lines.Materials and Methods: A T24 bladder carcinoma cell line stably over expressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bfc3f89edc7c11f83af64b84cbae198
https://doi.org/10.1016/s0022-5347(05)65964-2
https://doi.org/10.1016/s0022-5347(05)65964-2
Autor:
Melissa C. Marr, Thomas L. Wallace, Paul A. Cossum, Rochelle W. Tyl, Christina B. Myers, Jeffrey L. Larson
Publikováno v:
Toxicological Sciences. 53:421-429
Nyotran is a liposomally encapsulated i.v. formulation of the antifungal polyene nystatin. This drug was evaluated in a series of reproductive toxicity studies, according to the guidelines outlined by the International Conference on Harmonization (IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3281bec05646d6e68f3c903eaae45b
https://doi.org/10.1093/toxsci/53.2.421
https://doi.org/10.1093/toxsci/53.2.421
Publikováno v:
International Journal of Toxicology. 19:33-42
ATRAGEN® is a liposome-encapsulated intravenous (IV) formulation of the anticancer drug all- trans-retinoic acid (tretinoin). Retinoids as a class of compounds produce a characteristic profile of toxicities collectively known as hypervitaminosis A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4009ff0c81c98d1ef10fabe1f21c53
https://doi.org/10.1080/109158100225024
https://doi.org/10.1080/109158100225024
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:1424-1428
The objective of this study was an interspecies comparison of free nystatin (NYS) and liposomal NYS (Nyotran) distribution in plasma. NYS and liposomal NYS at concentrations of 5, 10, and 20 μg of NYS/ml were incubated in human, dog, and rat plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d061efdb6e1b31a6a3c50a71d1cab290
https://doi.org/10.1128/aac.43.6.1424
https://doi.org/10.1128/aac.43.6.1424
Autor:
Barbara Moffat, Michael Roth, Paul A. Cossum, Sharon A. Chen, Bobbe L. Ferraiolo, Kevin A. Dwyer, Richard Vandlen
Publikováno v:
Pharmaceutical Research. :419-424
The pharmacokinetics and tissue distribution of a human relaxin were investigated after intravenous (iv) bolus administration to pregnant or nonpregnant rats. Human gene-2 relaxin (hRlx-2) serum concentrations after iv bolus administration were descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810ee63de30141219dfa1cd5886bc75c
https://doi.org/10.1023/a:1015863507496
https://doi.org/10.1023/a:1015863507496
Autor:
Scot A. Marsters, Jerome E. Groopman, Paul A. Cossum, Steven M. Chamow, Douglas H. Smith, Randal A. Byrn, Catherine Lucas, Timothy J. Gregory, Jennifer S. Johnson, Joyce Mordenti, Florian M. Wurm, Daniel J. Capon
Publikováno v:
Nature. 344:667-670
Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39daea74d303cd8d9c4426473ffdd02
https://doi.org/10.1038/344667a0
https://doi.org/10.1038/344667a0
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 53(1)
AR177 (Zintevir) is a 17-mer oligonucleotide that has been shown to have anti-HIV activity and to be a potent HIV-1 integrase inhibitor in vitro, and is among the first oligonucleotides to enter human clinical trials. Acute and multiple-dose intraven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1dc92e282fb4dbb6d2bfcaf220a80d
https://pubmed.ncbi.nlm.nih.gov/10653522
https://pubmed.ncbi.nlm.nih.gov/10653522
Autor:
Joshua O. Ojwang, Steven C. Parrott, Kishor M. Wasan, Paul A. Cossum, Manisha Ramaswamy, Wesley Wong, Thomas L. Wallace, Samson Ng
Publikováno v:
Antimicrobial agents and chemotherapy. 42(7)
The objective of the proposed study was to determine the distribution in plasma lipoprotein of free all- trans retinoic acid (ATRA) and liposomal ATRA (Atragen; composed of dimyristoyl phosphatidylcholine and soybean oil) following incubation in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fb02f2d2bff7e7ccd13de6c145a94a
https://pubmed.ncbi.nlm.nih.gov/9660998
https://pubmed.ncbi.nlm.nih.gov/9660998
Autor:
Elias Anaissie, Thomas L. Wallace, Paul A. Cossum, Gabriel Lopez-Berestein, John H. Rex, Victor L. Paetznick
The purpose of this study was to examine the activity of liposomal nystatin against a disseminated Aspergillus fumigatus infection in neutropenic mice. Mice were made neutropenic with 5-fluorouracil and were administered the antifungal drug intraveno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a4ab8ae3b6b5475bbf899d586966a1
https://europepmc.org/articles/PMC164099/
https://europepmc.org/articles/PMC164099/
