Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Paul A. Beare"'
Autor:
Carrie M. Long, Paul A. Beare, Diane Cockrell, Picabo Binette, Mahelat Tesfamariam, Crystal Richards, Matthew Anderson, Jessica McCormick-Ell, Megan Brose, Rebecca Anderson, Anders Omsland, Talima Pearson, Robert A. Heinzen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Lipopolysaccharide (LPS) phase variation is a critical aspect of virulence in many Gram-negative bacteria. It is of particular importance to Coxiella burnetii, the biothreat pathogen that causes Q fever, as in vitro propagation of this organ
Externí odkaz:
https://doaj.org/article/a0dbc7cdafb446f6aee58d667d80ebc3
Autor:
Gayatri Subramanian, Adam Hage, Friederike Feldmann, Abhilash I. Chiramel, Kristin L. McNally, Gail L. Sturdevant, Paul A. Beare, Sonja M. Best
Publikováno v:
Viruses, Vol 16, Iss 9, p 1377 (2024)
The unprecedented research effort associated with the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) included several extensive proteomic studies that identified host proteins that interact with individual viral gene produc
Externí odkaz:
https://doaj.org/article/b6f86d9456e7430c99d8646e2ca3fe4f
Autor:
Yongli Xiao, Paul A. Beare, Sonja M. Best, David M. Morens, Marshall E. Bloom, Jeffery K. Taubenberger
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of dete
Externí odkaz:
https://doaj.org/article/7e4c405387b44c7f8416fe26a2682682
Autor:
Carrie M. Long, Paul A. Beare, Diane Cockrell, Picabo Binette, Mahelat Tesfamariam, Crystal Richards, Matthew Anderson, Jessica McCormick-Ell, Megan Brose, Rebecca Anderson, Anders Omsland, Talima Pearson, Robert A. Heinzen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e437619e60f542a9bd7dca538dae0820
Autor:
Doulin C. Shepherd, Mohammed Kaplan, Naveen Vankadari, Ki Woo Kim, Charles L. Larson, Przemysław Dutka, Paul A. Beare, Edward Krzymowski, Robert A. Heinzen, Grant J. Jensen, Debnath Ghosal
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107210- (2023)
Summary: Coxiella burnetii is an obligate zoonotic bacterium that targets macrophages causing a disease called Q fever. It has a biphasic developmental life cycle where the extracellular and metabolically inactive small cell variant (SCV) transforms
Externí odkaz:
https://doaj.org/article/27c86346303a4fe4bee530fa4804c8f2
Autor:
Derek J. Fisher, Paul A. Beare
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The ability to genetically manipulate a pathogen is fundamental to discovering factors governing host–pathogen interactions at the molecular level and is critical for devising treatment and prevention strategies. While the genetic “toolbox” for
Externí odkaz:
https://doaj.org/article/7dc63fa1b75e48fc84d3648092969bf1
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Coxiella burnetii is a Gram-negative pathogen that infects a variety of mammalian hosts. Infection of domesticated ewes can cause fetal abortion, whereas acute human infection normally manifests as the flu-like illness Q fever. Successful ho
Externí odkaz:
https://doaj.org/article/cc47f8ea49ef41f0ac2c6b8bc2397181
Autor:
Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolim
Externí odkaz:
https://doaj.org/article/54c02ef4c7e14f2d8fd82a8b248817d9
Autor:
Carrie M. Long, Paul A. Beare, Diane C. Cockrell, Jonathan Fintzi, Mahelat Tesfamariam, Carl I. Shaia, Robert A. Heinzen
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. The current human Q fever vaccine, Q-VAX®, is a fixed, whole cell vaccine (WCV) licensed solely for use in Australia. C. burnetii WCV administration is associated w
Externí odkaz:
https://doaj.org/article/d0529c4e3ca2440ab6147266ba854488
Autor:
Arne Cordsmeier, Sven Rinkel, Myriam Jeninga, Jan Schulze-Luehrmann, Martha Ölke, Benedikt Schmid, Daniele Hasler, Gunter Meister, Georg Häcker, Michaela Petter, Paul A. Beare, Anja Lührmann
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2 (2022)
Inhibition of host cell apoptosis is crucial for survival and replication of several intracellular bacterial pathogens. To interfere with apoptotic pathways, some pathogens use specialized secretion systems to inject bacterial effector proteins into
Externí odkaz:
https://doaj.org/article/94ffbda6c9e34508bd66071b94b27c11