Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Paul A. B. Moretti"'
Autor:
Melissa R. Pitman, Alexander C. Lewis, Lorena T. Davies, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Jason A. Powell, Stuart M. Pitson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Sphingosine 1-phosphate (S1P) is a signaling lipid that has broad roles, working either intracellularly through various protein targets, or extracellularly via a family of five G-protein coupled receptors. Agents that selectively and specifi
Externí odkaz:
https://doaj.org/article/33e43ca8e5b04ae885c259055f017ce2
Autor:
Denis Tvorogov, Chloe A L Thompson‐Peach, Johannes Foßelteder, Mara Dottore, Frank Stomski, Suraiya A Onnesha, Kelly Lim, Paul A B Moretti, Stuart M Pitson, David M Ross, Andreas Reinisch, Daniel Thomas, Angel F Lopez
Publikováno v:
EMBO reports. 23(4)
Refereed/Peer-reviewed Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by immunotherapeutic approaches. We developed a s
Autor:
Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly defined. In this study, triggering an accumulation of ceramide in acute myeloid leukemia (AML) cells by inhibition of sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed8fbe2daf653ebbee791ab6b83276b
https://hdl.handle.net/11541.2/31406
https://hdl.handle.net/11541.2/31406
Autor:
Jeffrey M, Barrett, Kate A, Parham, Jyotsna B, Pippal, Michaelia P, Cockshell, Paul A B, Moretti, Sarah L, Brice, Stuart M, Pitson, Claudine S, Bonder
Publikováno v:
Microcirculation (New York, N.Y. : 1994). 18(7)
The use of endothelial progenitor cells in vascular therapies has been limited due to their low numbers present in the bone marrow and peripheral blood. The aim of this study was to investigate the effect of sphingosine kinase on the de-differentiati
Autor:
Jane L, Roberts, Paul A B, Moretti, Andrew L, Darrow, Claudia K, Derian, Mathew A, Vadas, Stuart M, Pitson
Publikováno v:
Analytical biochemistry. 331(1)
Sphingosine kinase catalyses the phosphorylation of sphingosine to generate sphingosine 1-phosphate, a lipid signaling molecule implicated in roles in a diverse range of mammalian cell processes through its action as both a ligand for G-protein-coupl