Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Paul A Wiggins"'
Autor:
Marcos H de Moraes, FoSheng Hsu, Dean Huang, Dustin E Bosch, Jun Zeng, Matthew C Radey, Noah Simon, Hannah E Ledvina, Jacob P Frick, Paul A Wiggins, S Brook Peterson, Joseph D Mougous
Publikováno v:
eLife, Vol 10 (2021)
When bacterial cells come in contact, antagonism mediated by the delivery of toxins frequently ensues. The potential for such encounters to have long-term beneficial consequences in recipient cells has not been investigated. Here, we examined the eff
Externí odkaz:
https://doaj.org/article/be2fdb917a1d4d3f92780957dc64d1bf
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006582 (2017)
The positioning of the DNA replication machinery (replisome) has been the subject of several studies. Two conflicting models for replisome localization have been proposed: In the Factory Model, sister replisomes remain spatially co-localized as the r
Externí odkaz:
https://doaj.org/article/fcdb97191a2443109537b9c0fcc7492e
Publikováno v:
eLife, Vol 6 (2017)
The canonical model of DNA replication describes a highly-processive and largely continuous process by which the genome is duplicated. This continuous model is based upon in vitro reconstitution and in vivo ensemble experiments. Here, we characterize
Externí odkaz:
https://doaj.org/article/817ca2606877437792a5f52eed166474
Autor:
Michele LeRoux, Robin L Kirkpatrick, Elena I Montauti, Bao Q Tran, S Brook Peterson, Brittany N Harding, John C Whitney, Alistair B Russell, Beth Traxler, Young Ah Goo, David R Goodlett, Paul A Wiggins, Joseph D Mougous
Publikováno v:
eLife, Vol 4 (2015)
The perception and response to cellular death is an important aspect of multicellular eukaryotic life. For example, damage-associated molecular patterns activate an inflammatory cascade that leads to removal of cellular debris and promotion of healin
Externí odkaz:
https://doaj.org/article/5b86101dfd184aa9950b938e2b29db83
Autor:
Cecilia Garmendia-Torres, Alexander Skupin, Sean A Michael, Pekka Ruusuvuori, Nathan J Kuwada, Didier Falconnet, Gregory A Cary, Carl Hansen, Paul A Wiggins, Aimée M Dudley
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99428 (2014)
P-bodies belong to a large family of RNA granules that are associated with post-transcriptional gene regulation, conserved from yeast to mammals, and influence biological processes ranging from germ cell development to neuronal plasticity. RNA granul
Externí odkaz:
https://doaj.org/article/2ac7b0475acb43e3983bad4b8ced7e11
Autor:
Bridget R Kulasekara, Cassandra Kamischke, Hemantha D Kulasekara, Matthias Christen, Paul A Wiggins, Samuel I Miller
Publikováno v:
eLife, Vol 2 (2013)
Individual cell heterogeneity is commonly observed within populations, although its molecular basis is largely unknown. Previously, using FRET-based microscopy, we observed heterogeneity in cellular c-di-GMP levels. In this study, we show that c-di-G
Externí odkaz:
https://doaj.org/article/84115591419e4746a218be14cb9935c4
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Lag-time analysis was developed to measure in vivo replisome dynamics. Observed dynamics are both locus and cell-cycle dependent: Pauses of seconds are observed at wild-type ribosomal DNA loci, as well as temporal fork velocity oscillations.
Externí odkaz:
https://doaj.org/article/8adaad3f881446bdb4801303f5a5b472
An important step towards understanding the mechanistic basis of the central dogma is the quantitative characterization of the dynamics of nucleic-acid-bound molecular motors in the context of the living cell, where a crowded cytoplasm as well as com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5ad802d11c49f2b8e13e3c0a5fc153
https://doi.org/10.1101/2022.08.13.503874
https://doi.org/10.1101/2022.08.13.503874
Autor:
Kevin J. Cutler, Carsen Stringer, Teresa W. Lo, Luca Rappez, Nicholas Stroustrup, S. Brook Peterson, Paul A. Wiggins, Joseph D. Mougous
Publikováno v:
Nature Methods
Advances in microscopy hold great promise for allowing quantitative and precise measurement of morphological and molecular phenomena at the single-cell level in bacteria; however, the potential of this approach is ultimately limited by the availabili
Advances in microscopy hold great promise for allowing quantitative and precise readouts of morphological and molecular phenomena at the single cell level in bacteria. However, the potential of this approach is ultimately limited by the availability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68dc82117a2782b4ebcfbcaedfedf98a
https://doi.org/10.1101/2021.11.03.467199
https://doi.org/10.1101/2021.11.03.467199