The relative timing of mutations in a breast cancer genome.

Autor: Scott Newman, Karen D Howarth, Chris D Greenman, Graham R Bignell, Simon Tavaré, Paul A W Edwards

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e64991 (2013)

Many tumors have highly rearranged genomes, but a major unknown is the relative importance and timing of genome rearrangements compared to sequence-level mutation. Chromosome instability might arise early, be a late event contributing little to cance

Externí odkaz: https://doaj.org/article/b8a9b8d7fde040cb8298a7c71a5609f6

Supplementary Table 1 from A Recurrent Chromosome Breakpoint in Breast Cancer at the NRG1/Neuregulin 1/Heregulin Gene

Autor: Paul A. W. Edwards, Daniel Birnbaum, Max Chaffanet, Carlos Caldas, Jocelyne Jacquemier, William J. Gullick, Stephen M. Hewitt, Grace M. Callagy, Jessica C. Pole, Maria J. Garcia, N. Gopalakrishna Iyer, José Adélaïde, Valérie-Jeanne Bardou, Christophe Ginestier, Suet-Feung Chin, Huai-En Huang

Supplementary Table 1 from A Recurrent Chromosome Breakpoint in Breast Cancer at the NRG1/Neuregulin 1/Heregulin Gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd92426bd91b1ccb368a92ff44a7fb47
https://doi.org/10.1158/0008-5472.22363997.v1

Machine learning to predict early recurrence after oesophageal cancer surgery

Autor: S A Rahman, R C Walker, M A Lloyd, B L Grace, G I van Boxel, B F Kingma, J P Ruurda, R van Hillegersberg, S Harris, S Parsons, S Mercer, E A Griffiths, J R O'Neill, R Turkington, R C Fitzgerald, T J Underwood, Ayesha Noorani, Rachael Fels Elliott, Paul A W Edwards, Nicola Grehan, Barbara Nutzinger, Jason Crawte, Hamza Chettouh, Gianmarco Contino, Xiaodun Li, Eleanor Gregson, Sebastian Zeki, Rachel de la Rue, Shalini Malhotra, Simon Tavaré, Andy G Lynch, Mike L Smith, Jim Davies, Charles Crichton, Nick Carroll, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Stephen J Hayes, Yeng Ang, Shaun R Preston, Sarah Oakes, Izhar Bagwan, Vicki Save, Richard J E Skipworth, Ted R Hupp, J Robert O'Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Timothy J Underwood, Fergus Noble, James P Byrne, Jamie J Kelly, Jack Owsley, Hugh Barr, Neil Shepherd, Oliver Old, Jesper Lagergren, James Gossage, Andrew Davies Fuju Chang, Janine Zylstra, Vicky Goh, Francesca D Ciccarelli, Grant Sanders, Richard Berrisford, Catherine Harden, David Bunting, Mike Lewis, Ed Cheong, Bhaskar Kumar, Simon L Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Victor Eneh, Laszlo Igali, Michael Scott, Shamila Sothi, Sari Suortamo, Suzy Lishman, George B Hanna, Christopher J Peters, Anna Grabowska

Publikováno v: on behalf of the OCCAMS Consortium, Rahman, S A, Walker, R C, Lloyd, M A, Grace, B L, van Boxel, G I, Kingma, B F, Ruurda, J P, van Hillegersberg, R, Harris, S, Parsons, S, Mercer, S, Griffiths, E A, O'Neill, J R, Turkington, R, Fitzgerald, R C & Underwood, T J 2020, ' Machine learning to predict early recurrence after oesophageal cancer surgery ', British Journal of Surgery, vol. 107, no. 8, pp. 1042-1052 . https://doi.org/10.1002/bjs.11461
The British Journal of Surgery

Background Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20–30 per cent despite the widespread use of neoadjuvant treatment. Quantification of this risk is difficult and existing models perform poorly. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baa9c5e8d31ed77fb83c07c2aab1614

Fusion genes and chromosome translocations in the common epithelial cancers

Autor: Paul A W, Edwards

Publikováno v: The Journal of pathology. 220(2)

It has been known for 25 years that fusion genes play a central role in leukaemias and sarcomas but they have been neglected in the common carcinomas, largely because of technical limitations of cytogenetics. In the last few years it has emerged that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1395a46f1770910b381190db265b1118
https://pubmed.ncbi.nlm.nih.gov/19921709

Differential cell adhesion may result from nonspecific interactions between cell surface glycoproteins

Autor: Paul A. W. Edwards

Publikováno v: Nature. 271(5642)

I SUGGEST that if different cell types have different glycoprotein coatings they will tend to adhere to each other with different intensities, and sort out into separate tissues simply as a result of weak nonspecific interactions between the glycopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab0dca91522f00580bb29e6b0129519
https://pubmed.ncbi.nlm.nih.gov/622165