Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Paul A Sigala"'
Autor:
Megan Okada, Paul A Sigala
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011713 (2023)
Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3]. Over the past decade, our understanding of apicoplast properties an
Externí odkaz:
https://doaj.org/article/dad606e623ab4ca084574e4633cdda4f
Autor:
Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala
Publikováno v:
eLife, Vol 11 (2022)
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes. We have elucidated a
Externí odkaz:
https://doaj.org/article/d6c5aa846c6547d3ac466ffd5e45ea8e
Autor:
Seyi Falekun, Jaime Sepulveda, Yasaman Jami-Alahmadi, Hahnbeom Park, James A Wohlschlegel, Paul A Sigala
Publikováno v:
eLife, Vol 10 (2021)
Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII a
Externí odkaz:
https://doaj.org/article/e26ae9a9b2774268824fb1a004ffa0c3
Publikováno v:
eLife, Vol 9 (2020)
Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1
Externí odkaz:
https://doaj.org/article/c357fa8c47ce43b2acf3f9e12132fa51
Autor:
Daniel E Goldberg, Paul A Sigala
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006511 (2017)
Externí odkaz:
https://doaj.org/article/523d4fb345c34ea380bbe2547ae5d8cb
Publikováno v:
eLife, Vol 4 (2015)
Heme metabolism is central to blood-stage infection by the malaria parasite Plasmodium falciparum. Parasites retain a heme biosynthesis pathway but do not require its activity during infection of heme-rich erythrocytes, where they can scavenge host h
Externí odkaz:
https://doaj.org/article/700a46cad72f4798a4d7905a7e0bc6de
Autor:
Daniel A Kraut, Paul A Sigala, Brandon Pybus, Corey W Liu, Dagmar Ringe, Gregory A Petsko, Daniel Herschlag
Publikováno v:
PLoS Biology, Vol 4, Iss 4, p e99 (2006)
A longstanding proposal in enzymology is that enzymes are electrostatically and geometrically complementary to the transition states of the reactions they catalyze and that this complementarity contributes to catalysis. Experimental evaluation of thi
Externí odkaz:
https://doaj.org/article/98182b1d63cf4d19b5b348af950fb4ae
Autor:
Tanya J. Espino-Sanchez, Henry Wienkers, Rebecca G. Marvin, Shai-anne Nalder, Aldo E. García-Guerrero, Peter E. VanNatta, Yasaman Jami-Alahmadi, Amanda Mixon Blackwell, Frank G. Whitby, James A. Wohlschlegel, Matthew T. Kieber-Emmons, Christopher P. Hill, Paul A. Sigala
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The mitochondrial electron transport chain (ETC) of Plasmodium malaria parasites is a major antimalarial drug target, but critical cytochrome (cyt) functions remain unstudied and enigmatic. Parasites express two distinct cyt c homologs ( c and c -2)
Autor:
Tanya J. Espino-Sanchez, Henry Wienkers, Rebecca G. Marvin, Shai-anne Nalder, Aldo E. García-Guerrero, Peter E. VanNatta, Yasaman Jami-Alahmadi, Amanda Mixon Blackwell, Frank G. Whitby, James A. Wohlschlegel, Matthew T. Kieber-Emmons, Christopher P. Hill, Paul A. Sigala
Publikováno v:
bioRxiv
The mitochondrial electron transport chain (ETC) ofPlasmodiummalaria parasites is a major antimalarial drug target, but critical cytochrome functions remain unstudied and enigmatic. Parasites express two distinct cytchomologs (candc-2) with unusually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3814302e47517bd5ef343f12627cd7f
https://europepmc.org/articles/PMC9900762/
https://europepmc.org/articles/PMC9900762/