Biofortification of wheat with zinc for eliminating deficiency in Pakistan: study protocol for a cluster-randomised, double-blind, controlled effectiveness study (BIZIFED2)

Autor: Victoria Hall Moran, Nicola M Lowe, Mukhtiar Zaman, Heather Ohly, Jonathan Sinclair, Sadia Fatima, Martin R Broadley, Edward J M Joy, Usman Mahboob, R Murray Lark, Munir H Zia, E Louise Ander, Paul A Sharp, Elizabeth H Bailey, Scott D Young, Muhammad Jaffar Khan

Publikováno v: BMJ Open, Vol 10, Iss 11 (2020)

Introduction Micronutrient deficiencies, commonly referred to as ‘hidden hunger’, affect more than two billion people worldwide, with zinc and iron-deficiency frequently reported. The aim of this study is to examine the impact of consuming zinc b

Externí odkaz: https://doaj.org/article/1cca67a509f24696ade1a5b69cb5325a

Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption?

Autor: Palsa Kondaiah, Puneeta Singh Yaduvanshi, Paul A Sharp, Raghu Pullakhandam

Publikováno v: Nutrients, Vol 11, Iss 8, p 1885 (2019)

Iron and zinc are essential micronutrients required for growth and health. Deficiencies of these nutrients are highly prevalent among populations, but can be alleviated by supplementation and food fortification. Cross-sectional studies in humans show

Externí odkaz: https://doaj.org/article/56e25f7c04224dcd8f31ff6187119b8f

Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.

Autor: Fawaz Alzaid, Hoi-Man Cheung, Victor R Preedy, Paul A Sharp

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78932 (2013)

Polyphenols contained within plant tissues are consumed in significant amounts in the human diet and are known to influence a number of biological processes. This study investigated the effects of an anthocyanin-rich berry-extract on glucose uptake b

Externí odkaz: https://doaj.org/article/c604e581bf1d4c979fc1b74194bbcc11

A two-gene strategy increases iron and zinc concentrations in wheat flour, improving mineral bioaccessibility

Autor: Sophie A Harrington, James M Connorton, Natasha I M Nyangoma, Rose McNelly, Yvie M L Morgan, Mohamad F Aslam, Paul A Sharp, Alexander A T Johnson, Cristobal Uauy, Janneke Balk

Publikováno v: Plant Physiology. 191:528-541

Dietary deficiencies of iron and zinc cause human malnutrition that can be mitigated by biofortified staple crops. Conventional breeding approaches to increase grain mineral concentrations in wheat (Triticum aestivum L.) have had only limited success

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3dcf142ae8631d2b31a1f2ab75b75e
https://doi.org/10.1093/plphys/kiac499

Malaria-driven adaptation of MHC class I in wild bonobo populations

Autor: Emily E. Wroblewski, Lisbeth A. Guethlein, Aaron G. Anderson, Weimin Liu, Yingying Li, Sara E. Heisel, Andrew Jesse Connell, Jean-Bosco N. Ndjango, Paco Bertolani, John A. Hart, Terese B. Hart, Crickette M. Sanz, David B. Morgan, Martine Peeters, Paul M. Sharp, Beatrice H. Hahn, Peter Parham

Publikováno v: Wroblewski, E E, Guethlein, L A, Anderson, A G, Liu, W, Li, Y, Heisel, S E, Connell, A J, Ndjango, J-B N, Bertolani, P, Hart, J A, Hart, T B, Sanz, C M, Morgan, D B, Peeters, M, Sharp, P M, Hahn, B H & Parham, P 2023, ' Malaria-driven adaptation of MHC class I in wild bonobo populations ', Nature Communications, vol. 14, no. 1, 1033 . https://doi.org/10.1038/s41467-023-36623-9

The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell surface protein that presents peptide antigens to cytotoxic lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2687c45fd9f74a69b6005c64dd0db581
https://doi.org/10.1038/s41467-023-36623-9