Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Paul A Overbeek"'
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159800 (2016)
After using a self-inactivating lentivirus for non-targeted insertional mutagenesis in mice, we identified a transgenic family with a recessive mutation that resulted in reduced fertility in homozygous transgenic mice. The lentiviral integration site
Externí odkaz:
https://doaj.org/article/0ef7f3cff9624175b7215410433ae908
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0144285 (2016)
In most cases of primary ovarian insufficiency (POI), the cause of the depletion of ovarian follicles is unknown. Fanconi anemia (FA) proteins are known to play important roles in follicular development. Using random insertional mutagenesis with a le
Externí odkaz:
https://doaj.org/article/96f85225ce3344e2950b8c4dd6eb0d94
Autor:
Yalda Moayedi, Martin L Basch, Natasha L Pacheco, Simon S Gao, Rosalie Wang, Wilbur Harrison, Ningna Xiao, John S Oghalai, Paul A Overbeek, Graeme Mardon, Andrew K Groves
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004055 (2014)
The Notch signaling pathway is thought to regulate multiple stages of inner ear development. Mutations in the Notch signaling pathway cause disruptions in the number and arrangement of hair cells and supporting cells in sensory regions of the ear. In
Externí odkaz:
https://doaj.org/article/2280be277ac146019ba8888a9e473d2a
Autor:
Tyler F Beck, Oleg A Shchelochkov, Zhiyin Yu, Bum Jun Kim, Andrés Hernández-García, Hitisha P Zaveri, Colin Bishop, Paul A Overbeek, David W Stockton, Monica J Justice, Daryl A Scott
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58830 (2013)
The FRAS1-related extracellular matrix 1 (FREM1) gene encodes an extracellular matrix protein that plays a critical role in the development of multiple organ systems. In humans, recessive mutations in FREM1 cause eye defects, congenital diaphragmatic
Externí odkaz:
https://doaj.org/article/852a64d22ccb4780b78942d97ab281d2
Autor:
Amy N Hicks, Diego Lorenzetti, Jonathan Gilley, Baisong Lu, Karl-Erik Andersson, Carol Miligan, Paul A Overbeek, Ronald Oppenheim, Colin E Bishop
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47869 (2012)
Using transposon-mediated gene-trap mutagenesis, we have generated a novel mouse mutant termed Blad (Bloated Bladder). Homozygous mutant mice die perinatally showing a greatly distended bladder, underdeveloped diaphragm and a reduction in total skele
Externí odkaz:
https://doaj.org/article/0d47a60d35404710b566c484673bb393
Autor:
Jianning Tao, Maranke I Koster, Wilbur Harrison, Jennifer L Moran, David R Beier, Dennis R Roop, Paul A Overbeek
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50634 (2012)
Congenital ichthyoses are life-threatening conditions in humans. We describe here the identification and molecular characterization of a novel recessive mutation in mice that results in newborn lethality with severe congenital lamellar ichthyosis. Mu
Externí odkaz:
https://doaj.org/article/97bc5b5358324116b675620785b78efe
Autor:
Koki Mise, Daniel L. Galvan, Lin Tan, Shwetha V. Kumar, Jianyin Long, Farhad R. Danesh, Phillip L. Lorenzi, Wai Kin Chan, Li Li, Paul A. Overbeek, Benny Hung-Junn Chang
Publikováno v:
SSRN Electronic Journal.
Long non-coding RNA Tug1 is emerging as a novel therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its protection in vivo remains poorly understood. Here we generated a triple mutant diabetic mouse model co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b029d6f536c538b5f5e6f515462659cc
https://doi.org/10.2139/ssrn.3828203
https://doi.org/10.2139/ssrn.3828203
Autor:
Yumei Li, Paul A. Overbeek, Rui Chen, Graeme Mardon, Feng He, Theodore G. Wensel, Antrix Jain, Zhixian Zhang, Michael A. Robichaux, Thanh-Minh T. Nguyen, Ronald Roepman, Aiden Eblimit, Sung Yun Jung, Jun Qin, Rachayata Dharmat
Publikováno v:
Journal of Cell Biology, 217, 2851-2865
Journal of Cell Biology, 217, 8, pp. 2851-2865
The Journal of Cell Biology
Journal of Cell Biology, 217, 8, pp. 2851-2865
The Journal of Cell Biology
The connecting cilium (CC) of photoreceptor cells is considered analogous to the primary cilium transition zone (TZ). Dharmat et al. identify two subzones within the CC: the TZ-like posterior CC and a novel photoreceptor-specific zone in the distal C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ea896e6c6b39ccde9621cc7ef9404b
https://doi.org/10.1083/jcb.201712117
https://doi.org/10.1083/jcb.201712117
Autor:
Paul A. Overbeek, Paul T. Schumacker, Farhad R. Danesh, Benny Hung-Junn Chang, Shawn S. Badal, Daniel L. Galvan, Jianyin Long
Publikováno v:
Kidney International. 92:1282-1287
While increased mitochondrial reactive oxygen species have been commonly implicated in a variety of disease states, their in vivo role in the pathogenesis of diabetic nephropathy remains controversial. Using a two-photon imaging approach with a genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f50c6e2b21ba754545bfd431dfeaad
https://doi.org/10.1016/j.kint.2017.05.015
https://doi.org/10.1016/j.kint.2017.05.015
Autor:
Brendan Lee, Jianshuang Li, Di Lu, Paul A. Overbeek, Bart O. Williams, Ling Zheng, Huadie Liu, Tao Yang
Publikováno v:
Human Molecular Genetics. 26:2949-2960
Ciliopathies form a group of inherited disorders sharing several clinical manifestations because of abnormal cilia formation or function, and few treatments have been successful against these disorders. Here, we report a mouse model with mutated Sclt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb0c82728b18cf5705e200b93667556
https://doi.org/10.1093/hmg/ddx183
https://doi.org/10.1093/hmg/ddx183