Zobrazeno 1 - 10
of 376
pro vyhledávání: '"Paul A O'Neill"'
Autor:
Harry T Child, Paul A O'Neill, Karen Moore, William Rowe, Hubert Denise, David Bass, Matthew J Wade, Matt Loose, Steve Paterson, Ronny van Aerle, Aaron R Jeffries
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284211 (2023)
Monitoring the spread of viral pathogens in the population during epidemics is crucial for mounting an effective public health response. Understanding the viral lineages that constitute the infections in a population can uncover the origins and trans
Externí odkaz:
https://doaj.org/article/c02abb457b0c433281432f78968641bc
Publikováno v:
Journal of Saudi Chemical Society, Vol 26, Iss 6, Pp 101539- (2022)
The efficacy of most marketed antimalarial drugs has been compromised by the development of parasite resistance, underscoring an urgent need to find new drugs with new mechanisms of action. This article describes the synthesis and the in vitro antima
Externí odkaz:
https://doaj.org/article/1f4e1c9472b5478daa5da507d6fb6f93
Autor:
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenmig Jin, Michael Rogers, Yao Zhao, Zihe Rao, Zhi-Jie Liu, Haitao Yang, Leike Zhang, Paul M. O’Neill, S. Samar Hasnain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Ebselen is an organoselenium drug that inhibits the SARS-CoV-2 main protease (Mpro). Here, the authors co-crystallised Mpro with ebselen and an ebselen derivative and observed an enzyme bound organoselenium covalent adduct in the crystal structures,
Externí odkaz:
https://doaj.org/article/8cf917f0f0d94c58998c45d6d9518f5b
Autor:
Kangsa Amporndanai, Nattapon Pinthong, Paul M. O’Neill, W. David Hong, Richard K. Amewu, Chandrakala Pidathala, Neil G. Berry, Suet C. Leung, Stephen A. Ward, Giancarlo A. Biagini, S. Samar Hasnain, Svetlana V. Antonyuk
Publikováno v:
Biology, Vol 11, Iss 8, p 1109 (2022)
Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Qo site. Recent findings show
Externí odkaz:
https://doaj.org/article/b74084f8e68b4a56bee023bd1e647e27
Autor:
Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which
Externí odkaz:
https://doaj.org/article/53df786506df4fffaf54431621d57eba
Autor:
Claudia M. Hemsley, Paul A. O’Neill, Angela Essex-Lopresti, Isobel H. Norville, Tim P. Atkins, Richard W. Titball
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. An improved understanding of the genetic diversity of C. burnetii is essenti
Externí odkaz:
https://doaj.org/article/7feff0f378f241909797f32a6bc2f5c7
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Shi Quan Wong, Matthew G. Pontifex, Marie M. Phelan, Chandra Pidathala, Brian C. Kraemer, Jeff W. Barclay, Neil G. Berry, Paul M. O'Neill, Robert D. Burgoyne, Alan Morgan
Publikováno v:
Neurobiology of Disease, Vol 118, Iss , Pp 40-54 (2018)
The antiepileptic drug ethosuximide has recently been shown to be neuroprotective in various Caenorhabditis elegans and rodent neurodegeneration models. It is therefore a promising repurposing candidate for the treatment of multiple neurodegenerative
Externí odkaz:
https://doaj.org/article/a0a5900ed9fb48d482ef100848244392
Autor:
W. David Hong, Paul M. O’Neill, Mark J. Taylor, Joseph D. Turner, Stephen A. Ward, Fabian Gusovsky, Farid Benayoud, Nao Shibuguchi, Dixit Girish, Francis Gerard Fang, Ravi Kumar Talabhakthla, Anand Vaddi, Chiranjeevi Challa, Karri Satya Ammi Reddy, Vijay Kalla, Sugandham Srinivasa Rao, Durga Mahesh Kumar Nagireddi, Jayesh Patel, Anil Shahaji Khile
Publikováno v:
Organic Process Research & Development. 27:42-53
Autor:
Laura N. Jeffreys, Alison Ardrey, Taghreed A. Hafiz, Lauri-Anne Dyer, Ashley J. Warman, Nada Mosallam, Gemma L. Nixon, Nicholas E. Fisher, W. David Hong, Suet C. Leung, Ghaith Aljayyoussi, Jaclyn Bibby, Deepak V. Almeida, Paul J. Converse, Nader Fotouhi, Neil G. Berry, Eric L. Nuermberger, Anna M. Upton, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
ACS Infectious Diseases. 9:221-238