Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Paul A MacAry"'
Autor:
Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Publikováno v:
eLife, Vol 10 (2021)
The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, using amide hydrogen–deuterium exchange
Externí odkaz:
https://doaj.org/article/edbdeb7b5ce14846aca9ce972b3d86d3
Autor:
Conrad E Z Chan, Shirley G K Seah, De Hoe Chye, Shane Massey, Maricela Torres, Angeline P C Lim, Steven K K Wong, Jacklyn J Y Neo, Pui San Wong, Jie Hui Lim, Gary S L Loh, Dongling Wang, Jerome D Boyd-Kirkup, Siyu Guan, Dipti Thakkar, Guo Hui Teo, Kiren Purushotorman, Paul E Hutchinson, Barnaby E Young, Jenny G Low, Paul A MacAry, Hannes Hentze, Venkateshan S Prativadibhayankara, Kantharaj Ethirajulu, Jason E Comer, Chien-Te K Tseng, Alan D T Barrett, Piers J Ingram, Trevor Brasel, Brendon John Hanson
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253487 (2021)
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing windows. We report the generation and development of SC31, a potent SARS-CoV-2 neutralizin
Externí odkaz:
https://doaj.org/article/98d0e9238a8f44f8a516de81e7cb9d0e
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145381 (2015)
Anti-idiotype monoclonal antibodies represent a class of reagents that are potentially optimal for analyzing the pharmacokinetics of fully human, anti-infective antibodies that have been developed as therapeutic candidates. This is particularly impor
Externí odkaz:
https://doaj.org/article/8089ce1acbea4ca789c58c26602b3a8d
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89036 (2014)
Blastocystis spp. is a common enteric stramenopile parasite that colonizes the colon of hosts of a diverse array of species, including humans. It has been shown to compromise intestinal epithelial cell barrier integrity and mediate the production of
Externí odkaz:
https://doaj.org/article/063fa5edf2834260ab3118d09cd5054a
Autor:
Richard W. Titball, David I. Bernstein, Nicolas V. J. Fanget, Roy A. Hall, Stephanie Longet, Paul A. MacAry, Richard E. Rupp, Marit van Gils, Veronika von Messling, David H. Walker, Alan D. T. Barrett
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/3264d94ae350475589ae9dd8831f7222
Autor:
Ki Hyun Bae, Bhuvaneshwari Shunmuganathan, Li Zhang, Andrew Lim, Rashi Gupta, Yanming Wang, Boon Lin Chua, Yang Wang, Yue Gu, Xinlei Qian, Isabelle Siang Ling Tan, Kiren Purushotorman, Paul A. MacAry, Kevin P. White, Yi Yan Yang
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract The advent of SARS-CoV-2 variants with defined mutations that augment pathogenicity and/or increase immune evasiveness continues to stimulate global efforts to improve vaccine formulation and efficacy. The extraordinary advantages of lipid n
Externí odkaz:
https://doaj.org/article/6d09a079023146a59522e73433c8c050
Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
Autor:
Vojislav Jovanović, Nurhuda Abdul Aziz, Yan Ting Lim, Amanda Ng Ai Poh, Sherlynn Jin Hui Chan, Eliza Ho Xin Pei, Fei Chuin Lew, Guanghou Shui, Andrew M Jenner, Li Bowen, Eoin F McKinney, Paul A Lyons, Michael D Kemeny, Kenneth G C Smith, Markus R Wenk, Paul A Macary
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55639 (2013)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main
Externí odkaz:
https://doaj.org/article/e9d92f41f9d141d2bcea8a5d77b6f715
Autor:
Yue Gu, Bhuvaneshwari Shunmuganathan, Xinlei Qian, Rashi Gupta, Rebecca S. W. Tan, Mary Kozma, Kiren Purushotorman, Tanusya M. Murali, Nikki Y. J. Tan, Peter R. Preiser, Julien Lescar, Haziq Nasir, Jyoti Somani, Paul A. Tambyah, SCOPE Cohort Study Group, Kenneth G. C. Smith, Laurent Renia, Lisa F. P. Ng, David C. Lye, Barnaby E. Young, Paul A. MacAry
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. In this study, we describe the development
Externí odkaz:
https://doaj.org/article/274a4fa528b742699ad188ee670b344e
Autor:
Annie Hoi Yi Chan, Hwee Cheng Tan, Angelia Yee Chow, Angeline Pei Chiew Lim, Shee Mei Lok, Nicole J Moreland, Subhash G Vasudevan, Paul A MacAry, Eng Eong Ooi, Brendon J Hanson
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e33451 (2012)
Dengue virus (DENV) is a major mosquito-borne pathogen infecting up to 100 million people each year; so far no effective treatment or vaccines are available. Recently, highly cross-reactive and infection-enhancing pre-membrane (prM)-specific antibodi
Externí odkaz:
https://doaj.org/article/7adfda388ba34620a6adc94b80ebbc04
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24535 (2011)
Hydrogen sulfide (H(2)S) has been shown to induce transient receptor potential vanilloid 1 (TRPV1)-mediated neurogenic inflammation in polymicrobial sepsis. However, endogenous neural factors that modulate this event and the molecular mechanism by wh
Externí odkaz:
https://doaj.org/article/b2c367a9d44f49c080ae8a7ecf505fa2