Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Paul A Johnston"'
Autor:
David A. Close, Paul A. Johnston
Publikováno v:
SLAS Discovery, Vol 30, Iss , Pp 100201- (2025)
Patient derived tumor organoid (PDTO) models retain the structural, morphological, genetic, and clonal heterogeneity of the original tumors. The ability to efficiently generate, expand, and biobank PDTOs has the potential to make the clinical diversi
Externí odkaz:
https://doaj.org/article/b363b1add6bd4a7d82d47a7a7127e6de
Autor:
Cole A. McCormick, Hilary Corlett, Nick M. W. Roberts, Paul A. Johnston, Christopher J. Collom, Jack Stacey, Ardiansyah Koeshidayatullah, Cathy Hollis
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-13 (2024)
Abstract Fault-controlled, hydrothermal dolomitization often occurs at margins between shallow-water carbonate platforms and deep-water sedimentary basins. In western Canada, for example, the platform margin between the Cathedral Formation and the Bu
Externí odkaz:
https://doaj.org/article/abb21ec692c34605b692b28923ee1c4d
Autor:
Sager J Gosai, Joon Hyeok Kwak, Cliff J Luke, Olivia S Long, Dale E King, Kevin J Kovatch, Paul A Johnston, Tong Ying Shun, John S Lazo, David H Perlmutter, Gary A Silverman, Stephen C Pak
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15460 (2010)
The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, howe
Externí odkaz:
https://doaj.org/article/84a23b8725da453282e732e846ecd8d0
Autor:
Bernardo Antunes, Caroline Zanchi, Paul R Johnston, Bar Maron, Christopher Witzany, Roland R Regoes, Zvi Hayouka, Jens Rolff
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002692 (2024)
The prevalence of antibiotic-resistant pathogens has become a major threat to public health, requiring swift initiatives for discovering new strategies to control bacterial infections. Hence, antibiotic stewardship and rapid diagnostics, but also the
Externí odkaz:
https://doaj.org/article/ad2c8ebf23dd443cb17b6e234349bd7e
Autor:
Ashley T. Fancher, Yun Hua, David A. Close, Wei Xu, Lee A. McDermott, Christopher J. Strock, Ulises Santiago, Carlos J. Camacho, Paul A. Johnston
Publikováno v:
SLAS Discovery, Vol 28, Iss 7, Pp 325-343 (2023)
Three series of compounds were prioritized from a high content screening campaign that identified molecules that blocked dihydrotestosterone (DHT) induced formation of Androgen Receptor (AR) protein-protein interactions (PPIs) with the Transcriptiona
Externí odkaz:
https://doaj.org/article/1f522784d4774c6bb7d40f6419a475d6
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 698-704 (2023)
Malignant mesothelioma of the testes is an aggressive, yet rare urogenital malignancy, accounting for an infinitesimally small number of oncologic diagnoses. This infrequent occurrence is accompanied by a relative lack of knowledge surrounding this d
Externí odkaz:
https://doaj.org/article/cbe8ea8972a141a68ba78202306951c9
Autor:
Alondra Vázquez Rivera, Heather Donald, Mounia Alaoui-El-Azher, John J. Skoko, John S. Lazo, Michael A. Parniak, Paul A. Johnston, Nicolas Sluis-Cremer
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 819 (2024)
The ribonuclease H (RNase H) active site of HIV-1 reverse transcriptase (RT) is the only viral enzyme not targeted by approved antiretroviral drugs. Using a fluorescence-based in vitro assay, we screened 65,239 compounds at a final concentration of 1
Externí odkaz:
https://doaj.org/article/f8e64f106e54456d83df7089a79fcab8
Autor:
David A. Close, Paul A. Johnston
Publikováno v:
SLAS Discovery, Vol 29, Iss 1, Pp 130- (2024)
Externí odkaz:
https://doaj.org/article/986a40f16ea64e0ba49359391dc0032b
Autor:
Thorben Sieksmeyer, Shulin He, M. Alejandra Esparza-Mora, Shixiong Jiang, Vesta Petrašiūnaitė, Benno Kuropka, Ronald Banasiak, Mara Jean Julseth, Christoph Weise, Paul R. Johnston, Alexandro Rodríguez-Rojas, Dino P. McMahon
Publikováno v:
BMC Ecology and Evolution, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Host–pathogen interactions can lead to dramatic changes in host feeding behaviour. One aspect of this includes self-medication, where infected individuals consume substances such as toxins or alter their macronutrient consumptio
Externí odkaz:
https://doaj.org/article/d187b7af3f6b4418a308b1a4763809e6
Autor:
David A. Close, Paul A. Johnston
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 39-54 (2022)
In solid tumors like head and neck cancer (HNC), chronic and acute hypoxia have serious adverse clinical consequences including poorer overall patient prognosis, enhanced metastasis, increased genomic instability, and resistance to radiation-, chemo-
Externí odkaz:
https://doaj.org/article/e971a5d9dc9d46819f246bd958154abf