Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Paul A Grimsrud"'
Autor:
Alec G. Trub, Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J. Will Thompson, Olga R. Ilkayeva, Robert D. Stevens, Paul A. Grimsrud, Rhushikesh A. Kulkarni, Donald S. Backos, Jordan L. Meier, Matthew D. Hirschey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Statin therapy is associated with numerous cellular effects. Here, the authors show that statin treatment increases post-translational modifications on fatty acid synthase in the active site, revealing communication between the cholesterol and lipid
Externí odkaz:
https://doaj.org/article/6da5de5206424c06a24ccdd0b2b403ff
Autor:
Ashot Sargsyan, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, Henry H. Kou, Jonathan M. Haldeman, Michelle Arlotto, Phillip J. White, Paul A. Grimsrud, Inna Astapova, Linus T. Tsai, Mark A. Herman
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Carbohydrate response element–binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus
Externí odkaz:
https://doaj.org/article/ade443ac94814a119908baff8633073d
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108051- (2022)
STIM1 is an ER/SR transmembrane protein that interacts with ORAI1 to activate store operated Ca2+ entry (SOCE) upon ER/SR depletion of calcium. Normally highly expressed in skeletal muscle, STIM1 deficiency causes significant changes to mitochondrial
Externí odkaz:
https://doaj.org/article/d125f6344da6454d846204e94267e8bf
Autor:
Rebecca J. Wilson, Scott P. Lyons, Timothy R. Koves, Victoria G. Bryson, Hengtao Zhang, TianYu Li, Scott B. Crown, Jin-Dong Ding, Paul A. Grimsrud, Paul B. Rosenberg, Deborah M. Muoio
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101429- (2022)
Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STI
Externí odkaz:
https://doaj.org/article/64af5c6488244928abf80bd0658ef3e5
Autor:
Ashley S. Williams, Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, Deborah M. Muoio
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103635- (2022)
Summary: Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activ
Externí odkaz:
https://doaj.org/article/613c482ce3f74ec8b3a7c71691a2c885
Autor:
Kelsey H. Fisher-Wellman, James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, Robert D. Stevens, Gregory R. Wagner, Rami Najjar, Mathew D. Hirschey, J. Will Thompson, David P. Olson, Daniel P. Kelly, Timothy R. Koves, Paul A. Grimsrud, Deborah M. Muoio
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1557-1572.e8 (2019)
Summary: Acyl CoA metabolites derived from the catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translational modifications (PTMs). Mass spectrometry-based detection of thousan
Externí odkaz:
https://doaj.org/article/39224f9c894241779cbc18a277e18c11
Autor:
Wenxin Tong, Sarah A. Hannou, Ashot Sargsyan, Guo-Fang Zhang, Paul A. Grimsrud, Inna Astapova, Mark A. Herman
Publikováno v:
bioRxiv
ObjectiveTo investigate the effects of metformin on intestinal carbohydrate metabolismin vivo.Method: Male mice preconditioned with a high-fat, high-sucrose diet were treated orally with metformin or a control solution for two weeks. Fructose metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa691f02ad62ddad1443ce5a9c627932
https://doi.org/10.1101/2023.04.17.537251
https://doi.org/10.1101/2023.04.17.537251
Autor:
Timothy R. Koves, Guo-Fang Zhang, Michael T. Davidson, Alec B. Chaves, Scott B. Crown, Jordan M. Johnson, Dorothy H. Slentz, Paul A. Grimsrud, Deborah M. Muoio
Publikováno v:
Cell Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a3405045c0a4511799f52ee7e5c213d
https://doi.org/10.1016/j.cmet.2023.03.016
https://doi.org/10.1016/j.cmet.2023.03.016
Autor:
Eoin McDonnell, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, Matthew D. Hirschey
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1463-1472 (2016)
Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene expression program characterized by activating genes involved in its metabolism, in part by in
Externí odkaz:
https://doaj.org/article/7468bd7b52bb47b7833fa642f2a1852f
Autor:
Michael N. Davies, Lilja Kjalarsdottir, J. Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M. Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, Deborah M. Muoio
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 243-254 (2016)
Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on mitochondrial proteins and has been linked to metabolic dysfunction. An emergent theory suggests
Externí odkaz:
https://doaj.org/article/06329eac6e5c4b7a91f3336d78485c33