Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Paul A Gatenby"'
Autor:
Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in th
Externí odkaz:
https://doaj.org/article/78a180011b6f49c096a0159adcd221f4
Autor:
Zuopeng Wu, Rong Liang, Thomas Ohnesorg, Vicky Cho, Wesley Lam, Walter P Abhayaratna, Paul A Gatenby, Chandima Perera, Yafei Zhang, Belinda Whittle, Andrew Sinclair, Christopher C Goodnow, Matthew Field, T Daniel Andrews, Matthew C Cook
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006067 (2016)
Most humans harbor both CD177neg and CD177pos neutrophils but 1-10% of people are CD177null, placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia. By
Externí odkaz:
https://doaj.org/article/6e78e15a6d4e4a64bb492e26851408cc
Autor:
Marija Jelušić, Philip Wu, Jean Cappello, Anselm Enders, Maurice Stanley, Ilenia Papa, Julia I. Ellyard, Jeffrey J. Babon, Gaetan Burgio, Eric A. Stone, Jinghua Gu, Aaron Chuah, Lisa A. Miosge, Pablo F. Canete, Carmen de Lucas Collantes, James M. Byers, Jacob Cardenas, T. Andrews, Paul A. Gatenby, Matthew C. Cook, Kathryn P McKeon, Todor Arsov, Nan Shen, Eun Cho, Stephen I. Alexander, Arthur R Kitching, Matthew A. Field, David A. Fulcher, Virginia Pascual, Vicki Athanasopoulos, Savit B. Prabhu, Carola G. Vinuesa, Adrian C. Lungu, Giles Walters, Jonathan A. Roco, Velibor Tasic, Charlotte Burrin, Simon H Jiang, Amelia G. Cook, Mehmet Yabas, Dominic Mallon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci of weak effect act additively to predispose to common autoimmune diseases, while the contribution of rare variants rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd57f7c75cb27d937f805b8ceadb96b7
http://doi.org/10.1038/s41467-019-10242-9
http://doi.org/10.1038/s41467-019-10242-9
Autor:
Paul A. Gatenby, Richard A. Watts, Alfred Mahr, Luis Felipe Flores-Suárez, Neil Basu, Aladdin J Mohammad
Publikováno v:
Nephrology Dialysis Transplantation. 30:i14-i22
It is now 25 years since the first European studies on vasculitis--the anti-neutrophil cytoplasmic antibody (ANCA) standardization project. Over that period of time, there have been major developments in the classification of the vasculitides, which
Autor:
Paul A Gatenby
Publikováno v:
Journal of Vasculitis. 2
The review seeks to summarise the current ideas in regard to the pathogenesis of ANCA-associated vasculitis and to examine in detail how epidemiological and genetic factors fit with the modern paradigm. The recent literature has been reviewed. The AA
Autor:
Paul A. Gatenby
Publikováno v:
Internal Medicine Journal. 42:351-359
This review examines the environmental and genetic contributions to the anti-neutrophil cytoplasmic antibody-associated systemic vasculitides. The dominant environmental risk factors appear to be silica exposure for all three syndromes, and vitamin D
Autor:
Paul N. Smith, Paul A. Gatenby, Mingming Chen, Rachel W. Li, Craig Freeman, Di Yu, Christopher R. Parish
Publikováno v:
Journal of Orthopaedic Research. 28:1315-1322
Heparanase (HPSE) is known to be involved in fracture repair in mice, but its presence and function in human bone formation remains unclear. Our aim was to determine the expression of HPSE in human bone forming osteoblasts and to better understand it
Autor:
Paul A. Gatenby, Rosemary L Martin
Publikováno v:
Medical Teacher. 31:829-833
The development of a basic medical science curriculum in a new medical school with a problem-based focus in Australia has been subject to a number of constraints. We describe the process and early evaluation.To describe the development of a basic med
Publikováno v:
Journal of Clinical & Cellular Immunology.
Objective: Granulomatous polyangiitis patients generally have ANCA targeting Proteinase 3 (PR3), while microscopic polyangiitis and eosinophilic granulomatous polyangiitis patients generally have ANCA targeting myeloperoxidase (MPO). Patients positiv
Autor:
Thomas Faunce, Paul A. Gatenby
Publikováno v:
Medical Education. 39:1066-1074
Background Abraham Flexner's famous reports of 1910 and 1912, Medical Education in the United States and Canada and Medical Education in Europe, were written to assist the development of a positive response in university curricula to a revolution in