Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Paul A Flecknell"'
Autor:
Aimen O Amer, Philip M Probert, Michael Dunn, Margaret Knight, Abigail E Vallance, Paul A Flecknell, Fiona Oakley, Iain Cameron, Steven A White, Peter G Blain, Matthew C Wright
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136173 (2015)
Liver grafts donated after cardiac death are increasingly used to expand the donor pool but are prone to ischaemic-type biliary lesions. The anti-inflammatory effects of the activated pregnane X receptor have previously been shown to be beneficial in
Externí odkaz:
https://doaj.org/article/fd66d4993ea24264ab93994606a508ee
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103362 (2014)
Most pre-clinical analgesic efficacy assays still involve nociceptive testing in rodents. This is despite concerns as to the relevance of these tests for evaluating the pain-preventative properties of drugs. More appropriate methods would target pain
Externí odkaz:
https://doaj.org/article/bc891cae1b00457dabe00d12e11e012c
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75948 (2013)
Establishing effective cage-side pain assessment methods is essential if post-surgical pain is to be controlled effectively in laboratory animals. Changes to overall activity levels are the most common methods of assessment, but may not be the most a
Externí odkaz:
https://doaj.org/article/bc7e8b0d04684c0abac27f963a34ce24
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44437 (2012)
Ear tattooing is a routine procedure performed on laboratory, commercial and companion rabbits for the purpose of identification. Although this procedure is potentially painful, it is usually performed without the provision of analgesia, so compromis
Externí odkaz:
https://doaj.org/article/36dbc97d27e34649a0fa92a39258fb07
Autor:
Matthew C Leach, Kristel Klaus, Amy L Miller, Maud Scotto di Perrotolo, Susana G Sotocinal, Paul A Flecknell
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35656 (2012)
Current behaviour-based pain assessments for laboratory rodents have significant limitations. Assessment of facial expression changes, as a novel means of pain scoring, may overcome some of these limitations. The Mouse Grimace Scale appears to offer
Externí odkaz:
https://doaj.org/article/bfdc6cf10a2c4191a777c3d2729515e4
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32290 (2012)
Carbon dioxide (CO(2)) is the most commonly used euthanasia agent for rodents despite potentially causing pain and distress. Nitrous oxide is used in man to speed induction of anaesthesia with volatile anaesthetics, via a mechanism referred to as the
Externí odkaz:
https://doaj.org/article/f7825656615c42dbb7d406b8cb349daf
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e13347 (2011)
BackgroundSuccessful observation of behaviour depends upon knowing both which behaviours to look for and focusing on the appropriate areas of the body to observe them. Behaviour based scoring systems have become increasingly widely used to assess ani
Externí odkaz:
https://doaj.org/article/0d6e22e2926d4de48cfc59affe84467f
Autor:
Amy L. Miller, Jasmine M. Clarkson, Caroline Quigley, Vikki Neville, Caroline Krall, Annika Geijer-Simpson, Paul A. Flecknell, Matthew C. Leach
Publikováno v:
Miller, A, Clarkson, J, Quigley, C, Neville, V M, Krall, C, Geijer-Simpson, A, Flecknell, P & Leach, M 2022, ' Evaluating Pain and Analgesia Effectiveness Following Routine Castration in Rabbits Using Behavior and Facial Expressions ', Frontiers in Veterinary Science, vol. 9, 782486 . https://doi.org/10.3389/fvets.2022.782486
Prevention of pain in rabbits is a priority for both welfare and validity of scientific data. We aimed to determine if the rabbit grimace scale (RbtGS) could be used as a viable, rapid assessment tool in two breeds of rabbit, Dutch belted (DB) and Ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eab9bede8b2a9a1a764e4052881f5d3
https://eprints.gla.ac.uk/266006/1/266006.pdf
https://eprints.gla.ac.uk/266006/1/266006.pdf
Autor:
Henri Georges Michel Justin Bertrand, Paul A. Flecknell, Isabel S. Glover, Stuart N. Baker, Joseph Adam Middleton
Publikováno v:
Laboratory Animals
This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ac05c1191ed669bcfe46e82dfa5a3e
https://www.repository.cam.ac.uk/handle/1810/326685
https://www.repository.cam.ac.uk/handle/1810/326685
Autor:
Henri Bertrand, Paul A. Flecknell
Publikováno v:
Journal of Medical Primatology. 50:79-81
A 13-year-old rhesus macaque presented a cervical swelling associated with sudden deterioration of its condition. This mass was surgically removed, and its histopathological examination revealed a stratified squamous epithelium. This appearance has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c47d7e24aa9bf8af3dd8295f758869
https://doi.org/10.1111/jmp.12502
https://doi.org/10.1111/jmp.12502