Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Paul A Fitzpatrick"'
Autor:
Sean M Bell, Dan J Wendt, Yanhong Zhang, Timothy W Taylor, Shinong Long, Laurie Tsuruda, Bin Zhao, Phillip Laipis, Paul A Fitzpatrick
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173269 (2017)
Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is not
Externí odkaz:
https://doaj.org/article/ce5628e0933647178d98a97a916845ad
Autor:
Sofie Björner, Paul A Fitzpatrick, Yaoyong Li, Craig Allred, Anthony Howell, Anita Ringberg, Håkan Olsson, Crispin J Miller, Håkan Axelson, Göran Landberg
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105099 (2014)
Columnar cell hyperplasia (CCH) is the earliest histologically identifiable breast lesion linked to cancer progression and is characterized by increased proliferation, decreased apoptosis and elevated oestrogen receptor α (ERα) expression. The mech
Externí odkaz:
https://doaj.org/article/dbf585a938744e9aa54275639e708e54
Autor:
Paul F. Fitzpatrick
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2295-2307 (2018)
Because of nicotine’s toxicity and the high levels found in tobacco and in the waste from tobacco processing, there is a great deal of interest in identifying bacteria capable of degrading it. A number of microbial pathways have been identified for
Externí odkaz:
https://doaj.org/article/1b9fb95cd7f747dabb9c3f9800bc509a
Autor:
Beatrice N. Irungu, Jennifer A. Orwa, Amra Gruhonjic, Paul A. Fitzpatrick, Göran Landberg, Francis Kimani, Jacob Midiwo, Máté Erdélyi, Abiy Yenesew
Publikováno v:
Molecules, Vol 19, Iss 9, Pp 14235-14246 (2014)
A new triterpenoid, 3-oxo-12β-hydroxy-oleanan-28,13β-olide (1), and six known triterpenoids 2–7 were isolated from the root bark of Ekebergia capensis, an African medicinal plant. A limonoid 8 and two glycoflavonoids 9–10 were found in its leav
Externí odkaz:
https://doaj.org/article/9aba2c830f954780b40e555b16c5bf2e
Autor:
Stephen S. Nyandoro, Gasper Maeda, Joan J.E. Munissi, Amra Gruhonjic, Paul A. Fitzpatrick, Sofia Lindblad, Sandra Duffy, Jerry Pelletier, Fangfang Pan, Rakesh Puttreddy, Vicky M. Avery, Máté Erdélyi
Publikováno v:
Molecules, Vol 24, Iss 15, p 2746 (2019)
Phytochemical investigations of ethanol root bark and stem bark extracts of Cleistochlamys kirkii (Benth.) Oliv. (Annonaceae) yielded a new benzopyranyl cadinane-type sesquiterpene (cleistonol, 1) alongside 12 known compounds (2−13). The structures
Externí odkaz:
https://doaj.org/article/68b205b83ea14a2a8879648f35739b89
Autor:
Paul F. Fitzpatrick
Publikováno v:
Archives of Biochemistry and Biophysics. 735:109518
Autor:
Robert Livingstone, Hannah Burke, André Freitas, Michael Celinski, Hang Phan, Florina Borca, Paul A. Fitzpatrick, Oskar Wysocki, Anna Freeman, Paul O'Regan, Ahilanadan Dushianthan, Donal Landers, James Batchelor, Tom Wilkinson, Alastair Watson
Publikováno v:
Freeman, A, Watson, A, O'Regan, P, Wysocki, O, Burke, H, Freitas, A, Livingstone, R, Dushianthan, A, Celinski, M, Batchelor, J, Phan, H, Borca, F, Fitzpatrick, P, Landers, D & Wilkinson, T MA 2022, ' Wave comparisons of clinical characteristics and outcomes of COVID-19 admissions-Exploring the impact of treatment and strain dynamics ', Journal of Clinical Virology, vol. 146, 105031 . https://doi.org/10.1016/j.jcv.2021.105031
Journal of Clinical Virology
Journal of Clinical Virology
OBJECTIVES: Dexamethasone has now been incorporated into the standard of care for COVID-19 hospital patients. However, larger intensive care unit studies have failed to show discernible improvements in mortality in the recent wave. We aimed to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8602ba79d8e22602d0d83e8d08caf9
https://eprints.soton.ac.uk/455187/
https://eprints.soton.ac.uk/455187/
Autor:
Paul A. Fitzpatrick, Anna Gustafsson, Pernilla Gregersson, Elena Garre, Anders Ståhlberg, Göran Landberg, Maria del Carmen Leiva-Arrabal
Publikováno v:
Cancer Research. 80:P1-04
Despite great efficiencies of today’s anti-cancer therapies in breast cancer medicine, recurrences and metastasis still remains a major challenge. The tumor initiating population of cancer stem cells (CSC) is believed to promote metastasis and drug
Publikováno v:
Archives of Biochemistry and Biophysics. 729:109378
Phenylalanine hydroxylase (PheH) is a pterin-dependent, mononuclear nonheme iron(II) oxygenase that uses the oxidative power of Osub2/subto hydroxylate phenylalanine to form tyrosine. PheH is a member of a superfamily of Osub2/sub-activating enzymes
Autor:
Petro E. Mabeyo, Mkabwa L. K. Manoko, Amra Gruhonjic, Paul A. Fitzpatrick, Göran Landberg, Máté Erdélyi, Stephen S. Nyandoro
Publikováno v:
International Journal of Food Science, Vol 2015 (2015)
Selenium deficiency in humans has been associated with various diseases, the risks of which can be reduced through dietary supplementation. Selenium accumulating plants may provide a beneficial nutrient for avoiding such illnesses. Thus, leafy vegeta
Externí odkaz:
https://doaj.org/article/6d261280ab7c4111aa7613d844d2be43