Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State.

Autor: Steve Pells, Eirini Koutsouraki, Sofia Morfopoulou, Sara Valencia-Cadavid, Simon R Tomlinson, Ravi Kalathur, Matthias E Futschik, Paul A De Sousa

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131102 (2015)

Human embryonic stem cells (hESCs) undergo epigenetic changes in vitro which may compromise function, so an epigenetic pluripotency "signature" would be invaluable for line validation. We assessed Cytosine-phosphate-Guanine Island (CGI) methylation i

Externí odkaz: https://doaj.org/article/a23f5da6431c4b93b37c2f45b9627544

F12 Research participation: the view of persons at risk and persons with premanifest huntington’s disease

Autor: Zaynab Umakhanova, Paul A. De Sousa, Michaela Winkelmann, Rob Haselberg, Astri Arnesen, Marina Tretyakova, Danuta Lis, Beatrice De Schepper, Vladimír Václavík, Hans Gommans, Filipa Júlio, Emilie Hermant, Marios Papantoniou, Svein Olaf Olsen, Josè Perez Casanova, Cristina Ferreira, Ferdinando Squitieri, Ruth Blanco, Barbara D’Alessio, Sabrina Maffi, Dina De Sousa

Publikováno v: F: Clinical studies: case reports, observational studies and trials.

Background The development of effective therapies for Huntington’s disease (HD) requires an active, informed, and lasting commitment from HD families to research. Specifically, those traditionally less involved in studies should be heard and engage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36dc9885d09b8025453e84e38af537f0
https://doi.org/10.1136/jnnp-2021-ehdn.55

Challenges and advances in scale-up of label-free downstream processing for allogeneic cell therapies

Autor: Fernanda Masri, Marieke A. Hoeve, Paul A. De Sousa, Nicholas Willoughby

Publikováno v: Cell and Gene Therapy Insights. 3:447-467

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::858c3af7c0cb92340aa1a84060cf0dfd
https://doi.org/10.18609/cgti.2017.041

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience

Autor: Oliver Brüstle, Annette Ringwald, Christian Clausen, Charlotte Chapman, Glyn Stacey, Alexander J. Kvist, Marieke A. Hoeve, Shailesh Kumar Gupta, Blanca Miranda Serano, Minal Patel, Gabriella Brolén, Tomo Saric, George McConnachie, Cornelia Thiele, Julie Holder, Trisha Rawat, Tina C. Stummann, Joh Dokler, Maja Brajnik, Bryan Bolton, Lyle Armstrong, Bernd Kuebler, Alfredo Cabrera-Socorro, Isobel Atkin, Adam Faulconbridge, Christa Lucas, Jason A. King, Johannes Dewender, Ian Streeter, Rok Predan, Majlinda Lako, Lyn Healy, Bjørn Holst, Martine Geraerts, Luca Cherubin, Carsten Claussen, Heiko Zimmermann, Timothy E Allsopp, Orla O'Shea, Peter W. Harrison, K. Bruce, Niels Geijsen, Michael Peitz, Tony Burdett, Paul A. De Sousa, Ole Pless, Elisabeth Wachter, Anna Veiga, A. Courtney, Laura Clarke, Helen Parkinson, Cesar Trigueros, Anna Jonebring, Shalinee Khadun, Rachel Steeg, Patrik Foerch, Sascha Reimann, Ryan Hicks, Carol George, Andreas Ebneth, Oliver Keminer, Philip Gribbon, Barry Hardy, Stefanie Seltmann, Andreas Kurtz, Shawn Harmon, Jürgen Hescheler, Beate Kreisel

Publikováno v: Stem Cell Research, Vol 20, Iss C, Pp 105-114 (2017)
De Sousa, P A, Steeg, R, Wachter, E, Bruce, K, King, J, Hoeve, M, Khadun, S, Mcconnachie, G, Holder, J, Kurtz, A, Seltmann, S, Dewender, J, Reimann, S, Stacey, G, O'shea, O, Chapman, C, Healy, L, Zimmermann, H, Bolton, B, Rawat, T, Atkin, I, Veiga, A, Kuebler, B, Serano, B M, Saric, T, Hescheler, J, Brüstle, O, Peitz, M, Thiele, C, Geijsen, N, Holst, B, Clausen, C, Lako, M, Armstrong, L, Gupta, S K, Kvist, A J, Hicks, R, Jonebring, A, Brolén, G, Ebneth, A, Cabrera-socorro, A, Foerch, P, Geraerts, M, Stummann, T C, Harmon, S, George, C, Streeter, I, Clarke, L, Parkinson, H, Harrison, P W, Faulconbridge, A, Cherubin, L, Burdett, T, Trigueros, C, Patel, M J, Lucas, C, Hardy, B, Predan, R, Dokler, J, Brajnik, M, Keminer, O, Pless, O, Gribbon, P, Claussen, C, Ringwald, A, Kreisel, B, Courtney, A & Allsopp, T E 2017, ' Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) : The Hot Start experience ', Stem Cell Research, vol. 20, pp. 105-114 . https://doi.org/10.1016/j.scr.2017.03.002
Stem Cell Research, 20, 105. Elsevier
Stem Cell Research, 20, 105
Stem Cell Research, 20, 105-114
NARCIS
BASE (Open Access Aggregator)
UnpayWall
DOAJ-Articles
ORCID
Microsoft Academic Graph
Stem Cell Research, 20, 105-114. Elsevier B.V.
Stem Cell Research

A fast track “Hot Start” process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54bb6b7d2c9e8f837df5a8697d4288a
http://www.sciencedirect.com/science/article/pii/S1873506117300405

Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies

Autor: Siddharthan Chandran, Mark Head, Alison Green, Richard Knight, Diane Ritchie, Paul A. De Sousa

Publikováno v: De Sousa, P A, Ritchie, D, Green, A, Chandran, S, Knight, R & Head, M W 2018, ' Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies ', Acta Neuropathologica . https://doi.org/10.1007/s00401-018-1941-9
Acta Neuropathologica

The inadvertent transmission of long incubating, untreatable and fatal neurodegenerative prionopathies, notably iatrogenic Creutzfeldt–Jakob disease, following transplantation of cadaver-derived corneas, pituitary growth, hormones and dura mater, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec42998eb64d15c4d697aee2c6c76640
https://www.pure.ed.ac.uk/ws/files/77432124/Sousa2018_Article_RenewedAssessmentOfTheRiskOfEm.pdf