Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Paul A De Sousa"'
Autor:
Paul A. De Sousa, Leo Perfect, Jinpei Ye, Kay Samuels, Ewa Piotrowska, Martin Gordon, Ryan Mate, Elsa Abranches, Thomas M. Wishart, David H. Dockrell, Aidan Courtney
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both stem cell renewal and di
Externí odkaz:
https://doaj.org/article/bf13acb1260e4f5080469f86cb5609f0
Autor:
Paul A. De Sousa, Rachel Steeg, Elisabeth Wachter, Kevin Bruce, Jason King, Marieke Hoeve, Shalinee Khadun, George McConnachie, Julie Holder, Andreas Kurtz, Stefanie Seltmann, Johannes Dewender, Sascha Reimann, Glyn Stacey, Orla O'Shea, Charlotte Chapman, Lyn Healy, Heiko Zimmermann, Bryan Bolton, Trisha Rawat, Isobel Atkin, Anna Veiga, Bernd Kuebler, Blanca Miranda Serano, Tomo Saric, Jürgen Hescheler, Oliver Brüstle, Michael Peitz, Cornelia Thiele, Niels Geijsen, Bjørn Holst, Christian Clausen, Majlinda Lako, Lyle Armstrong, Shailesh K. Gupta, Alexander J. Kvist, Ryan Hicks, Anna Jonebring, Gabriella Brolén, Andreas Ebneth, Alfredo Cabrera-Socorro, Patrik Foerch, Martine Geraerts, Tina C. Stummann, Shawn Harmon, Carol George, Ian Streeter, Laura Clarke, Helen Parkinson, Peter W. Harrison, Adam Faulconbridge, Luca Cherubin, Tony Burdett, Cesar Trigueros, Minal J Patel, Christa Lucas, Barry Hardy, Rok Predan, Joh Dokler, Maja Brajnik, Oliver Keminer, Ole Pless, Philip Gribbon, Carsten Claussen, Annette Ringwald, Beate Kreisel, Aidan Courtney, Timothy E. Allsopp
Publikováno v:
Stem Cell Research, Vol 20, Iss C, Pp 105-114 (2017)
A fast track “Hot Start” process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) line
Externí odkaz:
https://doaj.org/article/d5c03414c1b04475bf195ed59dedab4f
Publikováno v:
Stem Cell Research, Vol 34, Iss , Pp - (2019)
Hypoxia benefits undifferentiated pluripotent stem cell renewal, and 2-oxoglutarate (2OG) dioxygenases have been implicated in pluripotent stem cell induction and renewal. We show in human embryonic stem cells (hESC) that an ambient oxygen-induced ox
Externí odkaz:
https://doaj.org/article/1749dabbe1414cdb8cd41963262ece05
Autor:
Margaret R. Davis, Erik Arner, Cairnan R.E. Duffy, Paul A. De Sousa, Ingrid Dahlman, Peter Arner, Kim M. Summers
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 851-857 (2016)
This article contains data related to the research article entitled “Expression of FBN1 during adipogenesis: relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions” [1]. The article concerns the expression of FBN1, the
Externí odkaz:
https://doaj.org/article/b364309db25b4f57ab9fd1e034b70dce
Autor:
Steve Pells, Eirini Koutsouraki, Sofia Morfopoulou, Sara Valencia-Cadavid, Simon R Tomlinson, Ravi Kalathur, Matthias E Futschik, Paul A De Sousa
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131102 (2015)
Human embryonic stem cells (hESCs) undergo epigenetic changes in vitro which may compromise function, so an epigenetic pluripotency "signature" would be invaluable for line validation. We assessed Cytosine-phosphate-Guanine Island (CGI) methylation i
Externí odkaz:
https://doaj.org/article/a23f5da6431c4b93b37c2f45b9627544
Autor:
Zaynab Umakhanova, Paul A. De Sousa, Michaela Winkelmann, Rob Haselberg, Astri Arnesen, Marina Tretyakova, Danuta Lis, Beatrice De Schepper, Vladimír Václavík, Hans Gommans, Filipa Júlio, Emilie Hermant, Marios Papantoniou, Svein Olaf Olsen, Josè Perez Casanova, Cristina Ferreira, Ferdinando Squitieri, Ruth Blanco, Barbara D’Alessio, Sabrina Maffi, Dina De Sousa
Publikováno v:
F: Clinical studies: case reports, observational studies and trials.
Background The development of effective therapies for Huntington’s disease (HD) requires an active, informed, and lasting commitment from HD families to research. Specifically, those traditionally less involved in studies should be heard and engage
Autor:
Xueying Yan, Sabrina Ehnert, Mihaela Culmes, Anastasia Bachmann, Claudine Seeliger, Lilianna Schyschka, Zhiyong Wang, Afshin Rahmanian-Schwarz, Ulrich Stöckle, Paul A De Sousa, Jaroslav Pelisek, Andreas K Nussler
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e90846 (2014)
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is critically discussed. A possible reason for reduced osteogenic potential may be an age-related deterioration of the Ad-MSCs. In long term in vitro cult
Externí odkaz:
https://doaj.org/article/8f86b6f89d2046239137840d288eb211
Autor:
Paul A. De Sousa
Publikováno v:
Essentials of Tissue and Cells Banking ISBN: 9783030716202
Twenty years on from the first reported isolation of pluripotent human embryonic stem cells (hESC) from in vitro fertilised preimplantation embryos, clinical evaluation of derivative cell products is ongoing. Contrary to expectations that pluripotenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43eba47f3ad66e20f2979e01be60cd93
https://doi.org/10.1007/978-3-030-71621-9_15
https://doi.org/10.1007/978-3-030-71621-9_15
Publikováno v:
Cell and Gene Therapy Insights. 3:447-467
Publikováno v:
De Sousa, P A, Steeg, R, Kreisel, B & Allsopp, T E 2017, ' Hot Start to European Pluripotent Stem Cell Banking ', Trends in biotechnology . https://doi.org/10.1016/j.tibtech.2017.04.006
Achieving consistency in standards of access to and quality of human induced pluripotent stem cells has lagged behind their use. In Europe, a network of academic and industrial partners has been established to overcome this challenge. The experience