Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul A Amor"'
Autor:
Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf
Autor:
David A. Beebe, Gregg D. Cappon, Michelle Clasquin, Marc K. Hellerstein, Norimitsu Shirai, William J. Reagan, Zhongyuan Sun, Katherine Hales, Gabriele E. Sonnenberg, Jeffrey A. Pfefferkorn, Theodore J. Schmahai, Nicholas B. Vera, Marcy Matthews, Trenton T. Ross, Clare Buckeridge, Enida Ziso Qejvanaj, Kenneth L. Kelly, Shoh Asano, Santos Carvajal-Gonzalez, William P. Esler, Paul A. Amor, Kelvin W. Li, Arthur Bergman
Publikováno v:
Nature Metabolism. 2:1163-1178
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37212bb75eaf160e3e8857af5cd7c6c9
https://doi.org/10.1038/s42255-020-00272-9
https://doi.org/10.1038/s42255-020-00272-9
Autor:
John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey
Publikováno v:
Journal of Medicinal Chemistry. 60:7835-7849
Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947
https://doi.org/10.1021/acs.jmedchem.7b00947
Autor:
Jeffrey A. Pfefferkorn, Matthew Gorgoglione, Scott M. Turner, Clare Buckeridge, Nicholas B. Vera, Marc K. Hellerstein, Annette M. Silvia, Gabriele E. Sonnenberg, Santos Carvajal-Gonzalez, Kathleen Biddle, Paul A. Amor, Raja K Sivamani, Lauren A Hassoun, David A. Griffith, Carine Beysen, Steven M. Watkins, Timothy P. Rolph, Julie Purkal, Mark Fitch, Gregory J. Tesz, William P. Esler, Frank J. Geoly, Suzana S. Bosanac
Publikováno v:
Science translational medicine. 11(492)
Sebum plays important physiological roles in human skin. Excess sebum production contributes to the pathogenesis of acne vulgaris, and suppression of sebum production reduces acne incidence and severity. We demonstrate that sebum production in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed755d8f32090787a27b2b7eaeec5c2b
https://pubmed.ncbi.nlm.nih.gov/31092695
https://pubmed.ncbi.nlm.nih.gov/31092695
Autor:
Laurel Sweet, Carine Beysen, William P. Esler, David Price, Alan M. Mathiowetz, David A. Griffith, Daniel W. Kung, Scott W. Bagley, Scott M. Turner, Gabriele E. Sonnenberg, Eric Ravussin, Santos Carvajal-Gonzalez, Felix Vajdos, Chris Limberakis, James A. Southers, Paul A. Amor, Shawn D. Doran, Kirk McPherson
Publikováno v:
Journal of Medicinal Chemistry
Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer. However, the identification of tool compounds suitable to test the hypothesis in human trials has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1aef7fc28748a6cde4608945069cb34
http://europepmc.org/articles/PMC4281100
http://europepmc.org/articles/PMC4281100
Autor:
David J. Edmonds, Shawn D. Doran, Dongxiang Zeng, Elnaz Menhaji-Klotz, Kathrine Loomis, Jana Polivkova, Kevin B. Bahnck, Tereece Banks, Dianna E. Moore, David A. Griffith, James A. Southers, Matthew F. Dunn, Aaron C. Smith, Carmen N. Garcia-Irizarry, Cathy Préville, William P. Esler, Kirk McPherson, Alan M. Mathiowetz, Paul A. Amor, David A. Beebe, Robert L. Dow, Scott W. Bagley, Kim Huard
Publikováno v:
Journal of Medicinal Chemistry. 56:7110-7119
Acetyl-CoA carboxylase (ACC) catalyzes the rate-determining step in de novo lipogenesis and plays a crucial role in the regulation of fatty acid oxidation. Alterations in lipid metabolism are believed to contribute to insulin resistance; thus inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cff94b0e675bc3976fd9e44bb5a85d
https://doi.org/10.1021/jm401033t
https://doi.org/10.1021/jm401033t
Autor:
Kathrine Loomis, Kristin L. Rockwell, Meihua Tu, Paul A. Amor, Kirk McPherson, William P. Esler, Tereece Banks, Aaron C. Smith, Shawn Cabral, James J. Valentine, Susan Tapley, Kristen Ford, Colin R. Rose, Mark Niosi, Felix Vajdos, Carmen N. Garcia-Irizarry, Shawn D. Doran, James A. Southers, Scott W. Bagley, Margaret S. Landis, Alan M. Mathiowetz, Daniel W. Kung, David A. Griffith
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
A novel series of spirocyclic-diamine based, isoform non-selective inhibitors of acetyl-CoA carboxylase (ACC) is described. These spirodiamine derivatives were discovered by design of a library to mimic the structural rigidity and hydrogen-bonding pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97747d7f1eb5d78c33f023f1c9e7174
https://pubmed.ncbi.nlm.nih.gov/26411795
https://pubmed.ncbi.nlm.nih.gov/26411795
Autor:
Timothy P. Rolph, Jiangli Yan, Levenia Baker, Alan Robertson, Vinicius Bonato, Jeffrey A. Pfefferkorn, Paul A. Amor, Jeff K. Trimmer, Theresa D’Aquila, Guoyun Bai, Derek M. Erion, Qingyun Yan, Yimin Zhu, Nicole Barucci, Matthew Gorgoglione, Nicholas B. Vera, Ronald W. Clark, Julie Purkal, Robert J. Aiello, Amanda L. Lapworth, Trenton T. Ross, Guodong Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
PLoS ONE
PLoS ONE
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ea8ae1d1d8d29924dda2ab8dfedf2
http://europepmc.org/articles/PMC4032240?pdf=render
http://europepmc.org/articles/PMC4032240?pdf=render
Publikováno v:
Journal of Bacteriology. 181:772-780
Escherichia coli O8:K40 coexpresses two distinct lipopolysaccharide (LPS) structures on its surface. The O8 polysaccharide is a mannose homopolymer with a trisaccharide repeat unit and is synthesized by an ABC-2 transport-dependent pathway. The K40 L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a92977e819804c5b34fa3c41d504a
https://doi.org/10.1128/jb.181.3.772-780.1999
https://doi.org/10.1128/jb.181.3.772-780.1999
Publikováno v:
Journal of Biological Chemistry. 273:29497-29505
The major core oligosaccharide biosynthesis operons from prototype Escherichia coli strains displaying R1 and R4 lipopolysaccharide core types were polymerase chain reaction-amplified and analyzed. Comparison of deduced products of the open reading f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00d6a2c673df7793e5196bee7181e577
https://doi.org/10.1074/jbc.273.45.29497
https://doi.org/10.1074/jbc.273.45.29497