Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Paul A, Welling"'
Autor:
Hyun Jun Jung, Truyen D. Pham, Xiao-Tong Su, Teodora Veronica Grigore, Joost G. Hoenderop, Hannes Olauson, Susan M. Wall, David H. Ellison, Paul A. Welling, Lama Al-Qusairi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Klotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief urinary K+ secretion channel (ROMK) an
Externí odkaz:
https://doaj.org/article/5dee2c3598f648a49e6f76465874f247
Autor:
Sepideh Gharaie, Kyungho Lee, Kathleen Noller, Emily K. Lo, Brendan Miller, Hyun Jun Jung, Andrea M. Newman-Rivera, Johanna T. Kurzhagen, Nirmish Singla, Paul A. Welling, Jean Fan, Patrick Cahan, Sanjeev Noel, Hamid Rabb
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract T cells are important in the pathogenesis of acute kidney injury (AKI), and TCR+CD4-CD8- (double negative-DN) are T cells that have regulatory properties. However, there is limited information on DN T cells compared to traditional CD4+ and C
Externí odkaz:
https://doaj.org/article/6ca1129e3f5c4b4882e9a4714dae46b0
Autor:
Pascal Schlosser, Jingning Zhang, Hongbo Liu, Aditya L. Surapaneni, Eugene P. Rhee, Dan E. Arking, Bing Yu, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee, Katalin Susztak, Josef Coresh, Morgan E. Grams
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney funct
Externí odkaz:
https://doaj.org/article/3b39686282454f09b5de897e371b742e
Autor:
P. Richard Grimm, Anamaria Tatomir, Lena L. Rosenbaek, Bo Young Kim, Dimin Li, Eric J. Delpire, Robert A. Fenton, Paul A. Welling
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Consumption of low dietary potassium, common with ultraprocessed foods, activates the thiazide-sensitive sodium chloride cotransporter (NCC) via the with no (K) lysine kinase/STE20/SPS1-related proline-alanine–rich protein kinase (WNK/SPAK) pathway
Externí odkaz:
https://doaj.org/article/8541e6222ebc4280b2bd08dad965885b
Autor:
Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Haojia Wu, Kohei Omachi, Nicolas Ledru, Parker C. Wilson, Andrew J. King, N. Eric Olson, Marvin G. Gunawan, Jay J. Kuo, Jennifer H. Cox, Jeffrey H. Miner, Stephen L. Seliger, Owen M. Woodward, Paul A. Welling, Terry J. Watnick, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD a
Externí odkaz:
https://doaj.org/article/7703e88d9d3a4383b2b0dd9ea8ab76ec
Autor:
Robert Little, Sathish K. Murali, Søren B. Poulsen, Paul R. Grimm, Adrienne Assmus, Lei Cheng, Jessica R. Ivy, Ewout J. Hoorn, Vladimir Matchkov, Paul A. Welling, Robert A. Fenton
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Dietary potassium (K+) supplementation is associated with a lowering effect in blood pressure (BP), but not all studies agree. Here, we examined the effects of short- and long-term K+ supplementation on BP in mice, whether differences depend on the a
Externí odkaz:
https://doaj.org/article/981aeff09de14897ba5e01c62266c1c4
Publikováno v:
Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Urinary K+ potassium excretion rapidly increases after a potassium‐rich meal. The early aldosterone‐induced sgk1 gene (encoding serum and glucocorticoid‐induced kinase 1), activates potassium clearance, but the role of this kinase in t
Externí odkaz:
https://doaj.org/article/847e56a4e23448cfb23311b8a5387672
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Aberrant activation of with-no-lysine kinase (WNK)-STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) kinase signaling in the distal convoluted tubule (DCT) causes unbridled activation of the thiazide-sensitive sodium chloride cotransporte
Externí odkaz:
https://doaj.org/article/6deba74d522e4a05b1b291d5bce74b60
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Tetracycline-inducible gene expression systems have been used successfully to study gene function in vivo and in vitro renal epithelial models but the effects of the common inducing agent, doxycycline (DOX), on gene expression are not well appreciate
Externí odkaz:
https://doaj.org/article/8977bd0e848e4b948ee8bed0357c0e64
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F256-F266
Regulation of the Cl−/[Formula: see text] exchanger pendrin has been suggested to explain the aldosterone paradox. A high-K+ diet has been proposed to downregulate a pendrin-mediated K+-sparing NaCl reabsorption pathway to maximize urinary K+ excre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53790a6565657cad6b47e1919db8486
https://doi.org/10.1152/ajprenal.00128.2022
https://doi.org/10.1152/ajprenal.00128.2022