Zobrazeno 1 - 10
of 540
pro vyhledávání: '"Paul A, Insel"'
Autor:
Anna Di Nardo, Yu-Ling Chang, Shahrzad Alimohammadi, Kana Masuda-Kuroki, Zhenping Wang, Krishna Sriram, Paul A. Insel
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112453- (2023)
Summary: Activation and degranulation of mast cells (MCs) is an essential aspect of innate and adaptive immunity. Skin MCs, the most exposed to the external environment, are at risk of quickly degranulating with potentially severe consequences. Here,
Externí odkaz:
https://doaj.org/article/2487de5043c04ae09fb74e888e81e019
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system—murine dendritic cells (DCs) with a DC-selective depletion of the heterotri
Externí odkaz:
https://doaj.org/article/de126dcb359a4e1ba9d7a7370df0e1e0
Autor:
Krishna Sriram, Shu Z. Wiley, Kevin Moyung, Matthew W. Gorr, Cristina Salmerón, Jordin Marucut, Randall P. French, Andrew M. Lowy, Paul A. Insel
Publikováno v:
ACS Omega, Vol 4, Iss 16, Pp 17048-17059 (2019)
Externí odkaz:
https://doaj.org/article/803525e5e05a4f8092a8f081d92b3d70
Autor:
S. Clare Stanford, Steve Alexander, Giuseppe Cirino, Christopher H. George, Paul A. Insel, Dave Kendall, Yong Ji, Reynold A. Panettieri, Hemal H. Patel, Christopher G. Sobey, Barbara Stefanska, Gary Stephens, Mauro Teixeira, Nathalie Vergnolle, Péter Ferdinandy, Amrita Ahluwalia
Publikováno v:
British Journal of Pharmacology. 180:1191-1196
Autor:
Eric Greenwald, Clara Posner, Ananya Bharath, Anne Lyons, Cristina Salmerón, Krishna Sriram, Shu Z. Wiley, Paul A. Insel, Jin Zhang
Publikováno v:
ACS Sens
A major limitation of time-lapse microscopy combined with fluorescent biosensors, a powerful tool for quantifying spatiotemporal dynamics of signaling in single living cells, is low-experimental throughput. To overcome this limitation, we created a h
Autor:
Jihyung Lee, Junyan Zhang, Young-Jun Chung, Jun Hwan Kim, Chae Min Kook, José M González-Navajas, David S Herdman, Bernd Nürnberg, Paul A Insel, Maripat Corr, Ji-Hun Mo, Ailin Tao, Kei Yasuda, Ian R Rifkin, David H Broide, Roger Sciammas, Nicholas JG Webster, Eyal Raz
Publikováno v:
eLife, Vol 9 (2020)
Cyclic AMP (cAMP) is involved in many biological processes but little is known regarding its role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent mechanism) regulates conventional type-
Externí odkaz:
https://doaj.org/article/022fd5c32ff749e39f658bfa0c3af487
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Chronic hypoxia from diseases in the lung, such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, can increase pulmonary vascular resistance, resulting in hypertrophy and dysfunction of the right ventr
Externí odkaz:
https://doaj.org/article/7ca406ab943c4b068e59585c4b3484dc
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000434 (2019)
G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mut
Externí odkaz:
https://doaj.org/article/f79a65962a274fcf817bacf7fa401bbb
Autor:
Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice
Externí odkaz:
https://doaj.org/article/7a2bc9f5eaee4df68bf0b1b7a219eba3
Autor:
Jerry Ingrande, Hemal H. Patel, Dave Kendall, Barbara Stefanska, Steve Alexander, Mick Bakhle, Giuseppe Cirino, James R. Docherty, Christopher H. George, Paul A. Insel, Yong Ji, Brian F. King, Elliot Lilley, Reynold A. Panettieri, Andrew G. Ramage, Christopher G. Sobey, S. Clare Stanford, Gary Stephens, Mauro Teixeira, Nathalie Vergnolle, Amrita Ahluwalia
Publikováno v:
British journal of pharmacologyREFERENCES. 180(3)
Scientists who plan to publish in the British Journal of Pharmacology (BJP) should read this article before undertaking studies utilising anaesthetics in mammalian animals. This editorial identifies certain gaps in the reporting of details on the use