Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Paul A, Bottomley"'
Autor:
T. Jake Samuel, Shenghan Lai, Michael Schär, Katherine C. Wu, Angela M. Steinberg, An-Chi Wei, Mark E. Anderson, Gordon F. Tomaselli, Gary Gerstenblith, Paul A. Bottomley, Robert G. Weiss
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
BACKGROUND Sudden cardiac death (SCD) remains a worldwide public health problem in need of better noninvasive predictive tools. Current guidelines for primary preventive SCD therapies, such as implantable cardioverter defibrillators (ICDs), are based
Externí odkaz:
https://doaj.org/article/30fc683480034dafa273757e78c76525
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background The heart’s energy demand per gram of tissue is the body’s highest and creatine kinase (CK) metabolism, its primary energy reserve, is compromised in common heart diseases. Here, neural-network analysis is used to test whether
Externí odkaz:
https://doaj.org/article/ba5ecb7d266343ee897d3d7b5267bdce
Autor:
Xiaoyang Liu, Parag Karmarkar, Dirk Voit, Jens Frahm, Clifford R. Weiss, Dara L. Kraitchman, Paul A. Bottomley
Publikováno v:
BME Frontiers, Vol 2021 (2021)
Objective. Atherosclerosis is a leading cause of mortality and morbidity. Optical endoscopy, ultrasound, and X-ray offer minimally invasive imaging assessments but have limited sensitivity for characterizing disease and therapeutic response. Magnetic
Externí odkaz:
https://doaj.org/article/79f7971dad1f40d093be88397869ba94
Autor:
Sabra C. Lewsey, Kilian Weiss, Michael Schär, Yi Zhang, Paul A. Bottomley, T. Jake Samuel, Qian-Li Xue, Angela Steinberg, Jeremy D. Walston, Gary Gerstenblith, Robert G. Weiss
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
BACKGROUND Physical frailty in older individuals is characterized by subjective symptoms of fatigue and exercise intolerance (EI). Objective abnormalities in skeletal muscle (SM) mitochondrial high-energy phosphate (HEP) metabolism contribute to EI i
Externí odkaz:
https://doaj.org/article/9d00fb014d2a4e1981d9df95a86648fb
Autor:
Refaat E. Gabr, AbdEl-Monem M. El-Sharkawy, Michael Schär, Gurusher S. Panjrath, Gary Gerstenblith, Robert G. Weiss, Paul A. Bottomley
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background It has been hypothesized that the supply of chemical energy may be insufficient to fuel normal mechanical pump function in heart failure (HF). The creatine kinase (CK) reaction serves as the heart’s primary energy reserve, and t
Externí odkaz:
https://doaj.org/article/daf1d707ef364b6aa0197557ef317e3e
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 19, Iss 1, Pp 1-13 (2017)
Abstract Background Atherosclerosis is prevalent in cardiovascular disease, but present imaging modalities have limited capabilities for characterizing lesion stage, progression and response to intervention. This study tests whether intravascular mag
Externí odkaz:
https://doaj.org/article/3d48c6cbae6d40758f27348a293a323e
The relative age effect in European elite soccer: A practical guide to Poisson regression modelling.
Autor:
John R Doyle, Paul A Bottomley
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0213988 (2019)
Many disciplines of scholarship are interested in the Relative Age Effect (RAE), whereby age-banding confers advantages on older members of the cohort over younger ones. Most research does not test this relationship in a manner consistent with theory
Externí odkaz:
https://doaj.org/article/da8de5413a2f413db716382252c10b6c
Autor:
Andrew Tyler, Jane Ellis, Justin Y. C. Lau, Jack J. Miller, Paul A. Bottomley, Christopher T. Rodgers, Damian J. Tyler, Ladislav Valkovič
Publikováno v:
Tyler, A, Ellis, J, Lau, J Y C, Miller, J J, Bottomley, P A, Rodgers, C T, Tyler, D J & Valkovič, L 2023, ' Compartment-based reconstruction of 3D acquisition-weighted 31 P cardiac magnetic resonance spectroscopic imaging at 7 T : A reproducibility study ', NMR in Biomedicine . https://doi.org/10.1002/nbm.4950
Even at 7 T, cardiac 31P magnetic resonance spectroscopic imaging (MRSI) is fundamentally limited by low signal-to-noise ratio (SNR), leading to long scan times and poor temporal and spatial resolutions. Compartment-based reconstruction algorithms su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908515559cbde1b8faac8297751af364
https://pure.au.dk/portal/da/publications/compartmentbased-reconstruction-of-3d-acquisitionweighted-31p-cardiac-magnetic-resonance-spectroscopic-imaging-at-7-t(69073100-3104-4126-a3fe-cd84b6ff5feb).html
https://pure.au.dk/portal/da/publications/compartmentbased-reconstruction-of-3d-acquisitionweighted-31p-cardiac-magnetic-resonance-spectroscopic-imaging-at-7-t(69073100-3104-4126-a3fe-cd84b6ff5feb).html
Autor:
John R Doyle, Paul A Bottomley
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192209 (2018)
The paper analyses two datasets of elite soccer players (top 1000 professionals and UEFA Under-19 Youth League). In both, we find a Relative Age Effect (RAE) for frequency, but not for value. That is, while there are more players born at the start of
Externí odkaz:
https://doaj.org/article/bbf2110e45b346e99649c93090995ba7
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176206 (2017)
The Relative Age Effect (RAE) documents the inherent disadvantages of being younger rather than older in an age-banded cohort, typically a school- or competition-year, to the detriment of career-progression, earnings and wellbeing into adulthood. We
Externí odkaz:
https://doaj.org/article/914a075fa67a4a76b97b822d504cfb12