Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Paul L. Richardson"'
Autor:
Radhika Narain, Ian Nessler, Paul L. Richardson, Jamie E. Erickson, Yuzhen Wang, Jacqueline Ferri, Heather L. Knight, Shaughn H. Bryant, Lucy A. Phillips, Liang Zhang, Soumya Mitra
Publikováno v:
npj Imaging, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract In this work, the impact of physicochemical modifications on pharmacokinetics and in vivo targeting of a small molecule fibroblast activation protein inhibitor (FAPI) imaging ligand in a murine model of rheumatoid arthritis was evaluated. Wh
Externí odkaz:
https://doaj.org/article/821384118fe54bc18bf98f999d4cbfe8
Autor:
Peter Kovar, Paul L Richardson, Alla Korepanova, Gustavo A Afanador, Vladimir Stojkovic, Tao Li, Michael R Schrimpf, Teresa I Ng, David A Degoey, Sujatha M Gopalakrishnan, Jun Chen
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100179- (2024)
The SARS-CoV-2 main protease (Mpro) is essential for viral replication because it is responsible for the processing of most of the non-structural proteins encoded by the virus. Inhibition of Mpro prevents viral replication and therefore constitutes a
Externí odkaz:
https://doaj.org/article/0e0b9455143c4b4e883db21e8a29ec2c
Autor:
Eric R. Goedken, Maria A. Argiriadi, Justin D. Dietrich, Andrew M. Petros, Navasona Krishnan, Sanjay C. Panchal, Wei Qiu, Haihong Wu, Haizhong Zhu, Ashley M. Adams, Pierre M. Bodelle, Lucas Goguen, Paul L. Richardson, Peter F. Slivka, Myron Srikumaran, Anup K. Upadhyay, Bainan Wu, Russell A. Judge, Anil Vasudevan, Sujatha M. Gopalakrishnan, Philip B. Cox, Vincent S. Stoll, Chaohong Sun
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Anti-IL17A therapies have proven effective for numerous inflammatory diseases including psoriasis, axial spondylitis and psoriatic arthritis. Modulating and/or antagonizing protein–protein interactions of IL17A cytokine binding to its cell
Externí odkaz:
https://doaj.org/article/73a129f16e244becaaa09ce714e81a66
Autor:
Sebastian Scheer, Suzanne Ackloo, Tiago S. Medina, Matthieu Schapira, Fengling Li, Jennifer A. Ward, Andrew M. Lewis, Jeffrey P. Northrop, Paul L. Richardson, H. Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David McLeod, Carlos A. Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V. M. Huber, Daniel D. De Carvalho, Masoud Vedadi, Colby Zaph, Peter J. Brown, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and
Externí odkaz:
https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Structures and PC3 viability IC50 data for compounds in Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450290df0d613596edbab94a5a07a69
https://doi.org/10.1158/1535-7163.22503433.v1
https://doi.org/10.1158/1535-7163.22503433.v1
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Supplementary methods, tables S1-S3, and supplementary figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7619544c11452e1775f6d92101867
https://doi.org/10.1158/1535-7163.22503430.v1
https://doi.org/10.1158/1535-7163.22503430.v1
Autor:
K. Salte, Paul L. Richardson, J.M. Herold, Chaohong Sun, Argiriadi, B. Sielaff, L. Medina, Heath A. McDonald, Sujatha M. Gopalakrishnan, Victoria E. Scott, W. Qiu, J. Wetter, S.J. Kakavas, S.E. Paulsboe, Ramkrishna Sadhukhan, Henning Stöckmann, Rodger F. Henry, J.B. Shotwell, Zhi Su, C.B. Putman, S. McGaraughty, Qi Sun, C. Gerstein, Viktor Todorović, P. Honore
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
IL-36 cytokines are pro-inflammatory members of the IL-1 family that are upregulated in inflammatory disorders. Specifically, IL-36γ is highly expressed in active psoriatic lesions and can drive pro-inflammatory processes in 3D human skin equivalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c770d40bc6d83141f82facd7f4fafb
http://link.springer.com/article/10.1038/s41598-019-45626-w
http://link.springer.com/article/10.1038/s41598-019-45626-w
Autor:
Paul M. Jung, Craig Wallace, Sonia Terrillon, Rachel Twomey, Paul L. Richardson, Peter Bousquet, Min Hu, Michelle Hart, Carolyn A. Cuff, Christian Goess, Tim Esbenshade, Martha Mayo, Marian Namovic, Diana Donnelly-Roberts, Suzanne Mathieu
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss, Pp 100079-(2021)
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity
Nuclear factor (erythroid-derived 2) like 2 (NRF2) is a nuclear transcription factor activated in response to oxidative stress that induces a gene program that dampens inflammation and can limit cell damage that perpetuates the inflammatory response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9cdbaab56bee492ed2de9ce8cca61c
http://www.sciencedirect.com/science/article/pii/S2589909020300460
http://www.sciencedirect.com/science/article/pii/S2589909020300460
Autor:
Minkui Luo, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Tiago Medina, H. Ümit Kaniskan, Matthieu Schapira, David Smil, Paul L. Richardson, Jian Jin, David McLeod, Colby Zaph, Andrew M. Lewis, Jennifer A. Ward, Daniel D. De Carvalho, Fengling Li, Sebastian Scheer, Jeffrey P. Northrop, Peter Brown, Kilian Huber, Yudao Shen, Suzanne Ackloo, Carlos Zepeda-Velázquez, Jing Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232475838ae5aaa7d608515b23b9da63
https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
Autor:
Xiaoqing Lu, Pete Bousquet, Paul L. Richardson, Grace Lynch, Lawrence Fong, John Mankovich, Dave Banach, Wendy Ritacco, Donald M. Simons, Susan V. Westmoreland, Chien-Chun Steven Pai, Mingyi Chen, Anthony Chang, Michael J. Evans, Junnian Wei, Chanhyuk Park, Diana Bowley, Jiaxi Wang, Yung Hua Wang, Gillian Kingsbury, John C. Huang, Feng Dong, Christine Beam, Soumya Mitra, Jane Seagal
Publikováno v:
The Journal of clinical investigation, vol 129, iss 1
While immune checkpoint blockade leads to potent antitumor efficacy, it also leads to immune-related adverse events in cancer patients. These toxicities stem from systemic immune activation resulting in inflammation of multiple organs, including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d6833216ef8190345646b5889fd26
https://doi.org/10.1172/jci123391
https://doi.org/10.1172/jci123391