Zobrazeno 1 - 10
of 740
pro vyhledávání: '"Paul J. Van Diest"'
Autor:
Marija Debeljak, Soonweng Cho, Bradley M. Downs, Michael Considine, Brittany Avin-McKelvey, Yongchun Wang, Phillip N. Perez, William E. Grizzle, Katherine A. Hoadley, Charles F. Lynch, Brenda Y. Hernandez, Paul J. van Diest, Wendy Cozen, Ann S. Hamilton, Debra Hawes, Edward Gabrielson, Ashley Cimino-Mathews, Liliana D. Florea, Leslie Cope, Christopher B. Umbricht
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Ductal carcinoma in-situ (DCIS) is a pre-invasive form of invasive breast cancer (IBC). Due to improved breast cancer screening, it now accounts for ~ 25% of all breast cancers. While the treatment success rates are over 90%, this
Externí odkaz:
https://doaj.org/article/a106b36b520948e78078f14a3c21f70b
Autor:
Marc Aubreville, Frauke Wilm, Nikolas Stathonikos, Katharina Breininger, Taryn A. Donovan, Samir Jabari, Mitko Veta, Jonathan Ganz, Jonas Ammeling, Paul J. van Diest, Robert Klopfleisch, Christof A. Bertram
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/79e04115ad314378bf65aa84a519e65d
Autor:
Antoine A. Khalil, Daan Smits, Peter D. Haughton, Thijs Koorman, Karin A. Jansen, Mathijs P. Verhagen, Mirjam van der Net, Kitty van Zwieten, Lotte Enserink, Lisa Jansen, Abdelrahman G. El-Gammal, Daan Visser, Milena Pasolli, Max Tak, Denise Westland, Paul J. van Diest, Cathy B. Moelans, M. Guy Roukens, Sandra Tavares, Anne-Marie Fortier, Morag Park, Riccardo Fodde, Martijn Gloerich, Fried. J. T. Zwartkruis, Patrick WB. Derksen, Johan de Rooij
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristic
Externí odkaz:
https://doaj.org/article/50e49d8f27e74b6aa43d0874b11c6389
Autor:
Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, Marjanka K. Schmidt
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether BRCA1-related bio
Externí odkaz:
https://doaj.org/article/ddff242b9c864f39864f3885aee7bad4
Autor:
Marc Aubreville, Frauke Wilm, Nikolas Stathonikos, Katharina Breininger, Taryn A. Donovan, Samir Jabari, Mitko Veta, Jonathan Ganz, Jonas Ammeling, Paul J. van Diest, Robert Klopfleisch, Christof A. Bertram
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract The prognostic value of mitotic figures in tumor tissue is well-established for many tumor types and automating this task is of high research interest. However, especially deep learning-based methods face performance deterioration in the pre
Externí odkaz:
https://doaj.org/article/83c2fd0cf0ca41988f96b88f3255e1a0
Autor:
Matthew E. Randolph, Marwa Afifi, Aparna Gorthi, Rachel Weil, Breelyn A. Wilky, Joshua Weinreb, Paul Ciero, Natalie ter Hoeve, Paul J. van Diest, Venu Raman, Alexander J.R. Bishop, David M. Loeb
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108925- (2024)
Summary: We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR)
Externí odkaz:
https://doaj.org/article/feee3811ebda42bda24ca7644f0ec5fe
Autor:
Iman J. Schultz, Yvette Zimmerman, Cathy B. Moelans, Marcin Chrusciel, Jan Krijgh, Paul J. van Diest, Ilpo T. Huhtaniemi, Herjan J. T. Coelingh Bennink
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundExpression of Zona Pellucida glycoprotein 3 (ZP3) in healthy tissue is restricted to the extracellular Zona Pellucida layer surrounding oocytes of ovarian follicles and to specific cells of the spermatogenic lineage. Ectopic expression of Z
Externí odkaz:
https://doaj.org/article/8ee16e995e5c4eb683f816de22705973
Deep learning-based breast cancer grading and survival analysis on whole-slide histopathology images
Autor:
Suzanne C. Wetstein, Vincent M. T. de Jong, Nikolas Stathonikos, Mark Opdam, Gwen M. H. E. Dackus, Josien P. W. Pluim, Paul J. van Diest, Mitko Veta
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Breast cancer tumor grade is strongly associated with patient survival. In current clinical practice, pathologists assign tumor grade after visual analysis of tissue specimens. However, different studies show significant inter-observer varia
Externí odkaz:
https://doaj.org/article/b59fee3b27c34ccfb9661b4cad529743
Autor:
Hannah W. Stutterheim, MB, Natalie D. ter Hoeve, BSc, Wiesje Maarse, MD, PhD, Elsken van der Wall, MD, PhD, Paul J. van Diest, MD, PhD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 11, Iss 6, p e4966 (2023)
Background:. Reduction mammaplasties are often performed at a relatively young age. Necessity of routine pathological investigation of the removed breast tissue to exclude breast cancer has been debated. Past studies have shown 0.05%–4.5% significa
Externí odkaz:
https://doaj.org/article/1f2e99622cbd419bb9bb2d0696b5bd8b
Autor:
Paul J van Diest, Carmen van Dooijeweert, Nikolas Stathonikos, Tri Q Nguyen, Natalie D ter Hoeve, Rachel N Flach
Publikováno v:
BMJ Open, Vol 13, Iss 6 (2023)
Introduction Artificial intelligence (AI) has been on the rise in the field of pathology. Despite promising results in retrospective studies, and several CE-IVD certified algorithms on the market, prospective clinical implementation studies of AI hav
Externí odkaz:
https://doaj.org/article/0bb29f9170b4425fb7cb5defa2d0093e