Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Paul J. Hensbergen"'
Autor:
Leoni Abendstein, Douwe J. Dijkstra, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Leendert A. Trouw, Paul J. Hensbergen, Thomas H. Sharp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented as an immunothe
Externí odkaz:
https://doaj.org/article/fcdc499f722c4bd9aa23f3e4ee0d4314
Autor:
Wiep Klaas Smits, Yassene Mohammed, Arnoud H. de Ru, Valentina Cordo', Annemieke H. Friggen, Peter A. van Veelen, Paul J. Hensbergen
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT Phosphorylation is a posttranslational modification that can affect both housekeeping functions and virulence characteristics in bacterial pathogens. In the Gram-positive enteropathogen Clostridioides difficile, the extent and nature of phos
Externí odkaz:
https://doaj.org/article/56db66355b294ec4b36a7a2c4b7b15ca
Autor:
Kevin K. Ng, Zachary E. Reinert, Jeroen Corver, Danica Resurreccion, Paul J. Hensbergen, Jennifer A. Prescher
Publikováno v:
Sensors, Vol 21, Iss 22, p 7485 (2021)
Current assays for Clostridioides difficile in nonhospital settings are outsourced and time-intensive, resulting in both delayed diagnosis and quarantining of infected individuals. We designed a more rapid point-of-care assay featuring a “turn-on
Externí odkaz:
https://doaj.org/article/b171d600edd042be9f3169e0703c8145
Autor:
Marijn A. Gillissen, Greta de Jong, Martijn Kedde, Etsuko Yasuda, Sophie E. Levie, Gemma Moiset, Paul J. Hensbergen, Arjen Q. Bakker, Koen Wagner, Jullien Villaudy, Pauline M. van Helden, Hergen Spits, Mette D. Hazenberg
Publikováno v:
Blood Advances, Vol 1, Iss 19, Pp 1551-1564 (2017)
Abstract: Immunotherapy has proven beneficial in many hematologic and nonhematologic malignancies, but immunotherapy for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) is hampered by the lack of tumor-specific targets. We took advant
Externí odkaz:
https://doaj.org/article/9c2e9b0e0ac74bdb8f673b5eba711700
Autor:
Guinevere S. M. Kammeijer, Bas C. Jansen, Isabelle Kohler, Anthonius A. M. Heemskerk, Oleg A. Mayboroda, Paul J. Hensbergen, Julie Schappler, Manfred Wuhrer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes. Due to very similar physico-chemi
Externí odkaz:
https://doaj.org/article/9b6a700734e940f1ad472f01a77e63ea
Autor:
Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoantibodies to myelin oligodendrocytes glycoprotein (MOG) are found in a fraction of patients with inflammatory demyelination and are detected with MOG-transfected cells. While the prototype anti-MOG mAb 8-18C5 and polyclonal anti-MOG responses fr
Externí odkaz:
https://doaj.org/article/0625c6d85031465797b02e7849f31245
Autor:
Martina Pirro, Yassene Mohammed, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Katarina Madunić, Manfred Wuhrer, Peter A. van Veelen, Paul J. Hensbergen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5369 (2021)
Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra had been used
Externí odkaz:
https://doaj.org/article/101ec0809c89474c8c4d44d86994d25c
Autor:
Surendra Kumar, Kolli, Alvaro, Molina-Cruz, Tamasa, Araki, Fiona J A, Geurten, Jai, Ramesar, Severine, Chevalley-Maurel, Hans J, Kroeze, Sascha, Bezemer, Clarize, de Korne, Roxanne, Withers, Nadia, Raytselis, Angela F, El Hebieshy, Robbert Q, Kim, Matthew A, Child, Soichiro, Kakuta, Hajime, Hisaeda, Hirotaka, Kobayashi, Takeshi, Annoura, Paul J, Hensbergen, Blandine M, Franke-Fayard, Carolina, Barillas-Mury, Ferenc A, Scheeren, Chris J, Janse
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(35)
Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24b873684a162fb0248f312ec6e217ef
https://pubmed.ncbi.nlm.nih.gov/35994647
https://pubmed.ncbi.nlm.nih.gov/35994647
Autor:
Fanny M. Deschepper, Roberta Zoppi, Martina Pirro, Paul J. Hensbergen, Fabio Dall’Olio, Maximillianos Kotsias, Richard A. Gardner, Daniel I.R. Spencer, Paula A. Videira
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8286 (2020)
Metastasis is the main cause of death among colorectal cancer (CRC) patients. E-selectin and its carbohydrate ligands, including sialyl Lewis X (sLeX) antigen, are key players in the binding of circulating tumor cells to the endothelium, which is one
Externí odkaz:
https://doaj.org/article/841a05b44131422282dca4d17bbe24ef
Autor:
Martina Pirro, Yassene Mohammed, Sandra J. van Vliet, Yoann Rombouts, Agnese Sciacca, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Manfred Wuhrer, Peter A. van Veelen, Paul J. Hensbergen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5522 (2020)
Colorectal cancer (CRC) is the second-leading cause of cancer death worldwide due in part to a high proportion of patients diagnosed at advanced stages of the disease. For this reason, many efforts have been made towards new approaches for early dete
Externí odkaz:
https://doaj.org/article/1be4b96ede544cd280d1e03c30f329df