Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Paul Hales"'
Autor:
Siegfried Janz, Brian Van Ness, Joseph B. Bolen, Mark Manfredi, Erik Kupperman, Allison J. Berger, Vishala T. Neppalli, Mary Carsillo, Paul Hales, Ping Li, Olga Tayber, Zhi Li, Michael Pickard, Ray Liu, Matthew D. Silva, Ozlem Subakan, Daniel P. Bradley, Jennifer Terkelsen, Kristen Bano, Jill Donelan, Bret Bannerman, Michael Fitzgerald, Edmund C. Lee
Purpose: The clinical success of the first-in-class proteasome inhibitor bortezomib (VELCADE) has validated the proteasome as a therapeutic target for treating human cancers. MLN9708 is an investigational proteasome inhibitor that, compared with bort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf51cd992431bfa10c2e6773dbd8053
https://doi.org/10.1158/1078-0432.c.6520107
https://doi.org/10.1158/1078-0432.c.6520107
Autor:
Siegfried Janz, Brian Van Ness, Joseph B. Bolen, Mark Manfredi, Erik Kupperman, Allison J. Berger, Vishala T. Neppalli, Mary Carsillo, Paul Hales, Ping Li, Olga Tayber, Zhi Li, Michael Pickard, Ray Liu, Matthew D. Silva, Ozlem Subakan, Daniel P. Bradley, Jennifer Terkelsen, Kristen Bano, Jill Donelan, Bret Bannerman, Michael Fitzgerald, Edmund C. Lee
PDF file - 108K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd400a1ca08e8405e5d218dd1e0d4b
https://doi.org/10.1158/1078-0432.22444227.v1
https://doi.org/10.1158/1078-0432.22444227.v1
Autor:
Joe Bolen, Mark Rolfe, Mark Manfredi, Li Yu, Paul Fleming, Larry Dick, Christopher Tsu, Khristofer Garcia, Jonathan Blank, Jane Liu, Frank Bruzzese, Paul Hales, Yu Yang, Jie Yu, Allison Berger, Michael Fitzgerald, Bret Bannerman, Yueying Cao, Edmund C. Lee, Erik Kupperman
The proteasome was validated as an oncology target following the clinical success of VELCADE (bortezomib) for injection for the treatment of multiple myeloma and recurring mantle cell lymphoma. Consequently, severalgroups are pursuing the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01d07dcfcf19a153c02b55def60b337b
https://doi.org/10.1158/0008-5472.c.6500702
https://doi.org/10.1158/0008-5472.c.6500702
Autor:
Joe Bolen, Mark Rolfe, Mark Manfredi, Li Yu, Paul Fleming, Larry Dick, Christopher Tsu, Khristofer Garcia, Jonathan Blank, Jane Liu, Frank Bruzzese, Paul Hales, Yu Yang, Jie Yu, Allison Berger, Michael Fitzgerald, Bret Bannerman, Yueying Cao, Edmund C. Lee, Erik Kupperman
Supplementary Data, Figure Legends 1-3 from Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047537a2a69c0cda17d48c1520f0a30d
https://doi.org/10.1158/0008-5472.22383908
https://doi.org/10.1158/0008-5472.22383908
Autor:
Joe Bolen, Mark Rolfe, Mark Manfredi, Li Yu, Paul Fleming, Larry Dick, Christopher Tsu, Khristofer Garcia, Jonathan Blank, Jane Liu, Frank Bruzzese, Paul Hales, Yu Yang, Jie Yu, Allison Berger, Michael Fitzgerald, Bret Bannerman, Yueying Cao, Edmund C. Lee, Erik Kupperman
Supplementary Figure 3 from Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167a752aed7cf54345175b4a7222531b
https://doi.org/10.1158/0008-5472.22383899.v1
https://doi.org/10.1158/0008-5472.22383899.v1
Autor:
Eric S. Lightcap, Jay P. Morgenstern, James J. Spelman, Claudia Rabino, John Ringeling, Patrick J. Leroy, Paul Hales, Jesse Gray, Darshan S. Sappal, Khristofer Garcia, Wei Chen, Anne L. Burkhardt, Trupti Lingaraj, Denise L. Driscoll, Jie Yu, Saurabh Menon, Michael D. Pickard, David M. Rappoli, Xiaozhen J. Liu, Theodore Peters, Jonathan L. Blank, Siquan Chen
Supplementary Figures 5-7 from Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5550a69979710e76b33bf0c32049758a
https://doi.org/10.1158/0008-5472.22383065
https://doi.org/10.1158/0008-5472.22383065
Autor:
Eric S. Lightcap, Jay P. Morgenstern, James J. Spelman, Claudia Rabino, John Ringeling, Patrick J. Leroy, Paul Hales, Jesse Gray, Darshan S. Sappal, Khristofer Garcia, Wei Chen, Anne L. Burkhardt, Trupti Lingaraj, Denise L. Driscoll, Jie Yu, Saurabh Menon, Michael D. Pickard, David M. Rappoli, Xiaozhen J. Liu, Theodore Peters, Jonathan L. Blank, Siquan Chen
Supplementary Figure 8 from Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1f22fa15aad5f236df43c06c726794
https://doi.org/10.1158/0008-5472.22383071
https://doi.org/10.1158/0008-5472.22383071
Autor:
Joe Bolen, Mark Rolfe, Mark Manfredi, Li Yu, Paul Fleming, Larry Dick, Christopher Tsu, Khristofer Garcia, Jonathan Blank, Jane Liu, Frank Bruzzese, Paul Hales, Yu Yang, Jie Yu, Allison Berger, Michael Fitzgerald, Bret Bannerman, Yueying Cao, Edmund C. Lee, Erik Kupperman
Supplementary Figure 1 from Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b97042635affb441b3a3b3d21b28b2
https://doi.org/10.1158/0008-5472.22383905.v1
https://doi.org/10.1158/0008-5472.22383905.v1
Autor:
Eric S. Lightcap, Jay P. Morgenstern, James J. Spelman, Claudia Rabino, John Ringeling, Patrick J. Leroy, Paul Hales, Jesse Gray, Darshan S. Sappal, Khristofer Garcia, Wei Chen, Anne L. Burkhardt, Trupti Lingaraj, Denise L. Driscoll, Jie Yu, Saurabh Menon, Michael D. Pickard, David M. Rappoli, Xiaozhen J. Liu, Theodore Peters, Jonathan L. Blank, Siquan Chen
Supplementary Methods, Figure and Table Legends from Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0800f85e6a3c750e356d1153687ea4d6
https://doi.org/10.1158/0008-5472.22383062.v1
https://doi.org/10.1158/0008-5472.22383062.v1
Autor:
Eric S. Lightcap, Jay P. Morgenstern, James J. Spelman, Claudia Rabino, John Ringeling, Patrick J. Leroy, Paul Hales, Jesse Gray, Darshan S. Sappal, Khristofer Garcia, Wei Chen, Anne L. Burkhardt, Trupti Lingaraj, Denise L. Driscoll, Jie Yu, Saurabh Menon, Michael D. Pickard, David M. Rappoli, Xiaozhen J. Liu, Theodore Peters, Jonathan L. Blank, Siquan Chen
Multiple pathways have been proposed to explain how proteasome inhibition induces cell death, but mechanisms remain unclear. To approach this issue, we performed a genome-wide siRNA screen to evaluate the genetic determinants that confer sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447f83f4a5ac4ed58b1abc343d56192c
https://doi.org/10.1158/0008-5472.c.6500411
https://doi.org/10.1158/0008-5472.c.6500411