The EWAS Catalog: a database of epigenome-wide association studies [version 2; peer review: 2 approved]

Autor: Ryan Langdon, Matthew Suderman, Oliver Whitehurst, Hannah R. Elliott, Luke Mahoney, Matthew A. Lee, Caroline L. Relton, Giulia Mancano, Abigail C. Lay, Sarah H. Watkins, James R. Staley, Gibran Hemani, Thomas Battram, Gemma Crawford, Paul Yousefi, Mahsa Sheikhali Babaei, Tom R. Gaunt, Claire Prince, Charlie Hatcher, Gemma Sharp, Sahar Khodabakhsh, María Jesús Vega-Salas

Publikováno v: Wellcome Open Research, Vol 7 (2022)

Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, the increase in availability of DNA methylation me

Externí odkaz: https://doaj.org/article/14ac3ff9c265454984a40484d3a1fd77

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Autor: Leanne K. Küpers, Claire Monnereau, Gemma C. Sharp, Paul Yousefi, Lucas A. Salas, Akram Ghantous, Christian M. Page, Sarah E. Reese, Allen J. Wilcox, Darina Czamara, Anne P. Starling, Alexei Novoloaca, Samantha Lent, Ritu Roy, Cathrine Hoyo, Carrie V. Breton, Catherine Allard, Allan C. Just, Kelly M. Bakulski, John W. Holloway, Todd M. Everson, Cheng-Jian Xu, Rae-Chi Huang, Diana A. van der Plaat, Matthias Wielscher, Simon Kebede Merid, Vilhelmina Ullemar, Faisal I. Rezwan, Jari Lahti, Jenny van Dongen, Sabine A. S. Langie, Tom G. Richardson, Maria C. Magnus, Ellen A. Nohr, Zongli Xu, Liesbeth Duijts, Shanshan Zhao, Weiming Zhang, Michelle Plusquin, Dawn L. DeMeo, Olivia Solomon, Joosje H. Heimovaara, Dereje D. Jima, Lu Gao, Mariona Bustamante, Patrice Perron, Robert O. Wright, Irva Hertz-Picciotto, Hongmei Zhang, Margaret R. Karagas, Ulrike Gehring, Carmen J. Marsit, Lawrence J. Beilin, Judith M. Vonk, Marjo-Riitta Jarvelin, Anna Bergström, Anne K. Örtqvist, Susan Ewart, Pia M. Villa, Sophie E. Moore, Gonneke Willemsen, Arnout R. L. Standaert, Siri E. Håberg, Thorkild I. A. Sørensen, Jack A. Taylor, Katri Räikkönen, Ivana V. Yang, Katerina Kechris, Tim S. Nawrot, Matt J. Silver, Yun Yun Gong, Lorenzo Richiardi, Manolis Kogevinas, Augusto A. Litonjua, Brenda Eskenazi, Karen Huen, Hamdi Mbarek, Rachel L. Maguire, Terence Dwyer, Martine Vrijheid, Luigi Bouchard, Andrea A. Baccarelli, Lisa A. Croen, Wilfried Karmaus, Denise Anderson, Maaike de Vries, Sylvain Sebert, Juha Kere, Robert Karlsson, Syed Hasan Arshad, Esa Hämäläinen, Michael N. Routledge, Dorret I. Boomsma, Andrew P. Feinberg, Craig J. Newschaffer, Eva Govarts, Matthieu Moisse, M. Daniele Fallin, Erik Melén, Andrew M. Prentice, Eero Kajantie, Catarina Almqvist, Emily Oken, Dana Dabelea, H. Marike Boezen, Phillip E. Melton, Rosalind J. Wright, Gerard H. Koppelman, Letizia Trevisi, Marie-France Hivert, Jordi Sunyer, Monica C. Munthe-Kaas, Susan K. Murphy, Eva Corpeleijn, Joseph Wiemels, Nina Holland, Zdenko Herceg, Elisabeth B. Binder, George Davey Smith, Vincent W. V. Jaddoe, Rolv T. Lie, Wenche Nystad, Stephanie J. London, Debbie A. Lawlor, Caroline L. Relton, Harold Snieder, Janine F. Felix

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, ide

Externí odkaz: https://doaj.org/article/273b3fae48e541ca961b3e3fb67897bd

Chromosome 18 loss of heterozygosity in small intestinal neuroendocrine tumours: Multi-omic and tumour composition analyses

Autor: Scott Waterfield, Paul Yousefi, Amy Webster, Caroline Relton, Chrissie Thirlwell, Matt Suderman

Publikováno v: Neuroendocrinology.

Background: Small intestinal neuroendocrine tumours (siNETs) are rare neoplasms which present with low mutational burden and can be subtyped based on copy number variation (CNV). Currently, siNETs can be molecularly classified as having chromosome 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a43ba57558356eb4d3aab9c92cf727c
https://doi.org/10.1159/000530106

Epigenetic modelling of former, current and never smokers

Autor: Paul Yousefi, Matthew Suderman, Ryan Langdon, Caroline L Relton

Publikováno v: Langdon, R J, Yousefi, P D, Relton, C L & Suderman, M J 2021, ' Epigenetic modelling of former, current and never smokers ', Clinical Epigenetics, vol. 13, no. 1, 206 . https://doi.org/10.1186/s13148-021-01191-6
Clinical Epigenetics

Background DNA methylation (DNAm) performs excellently in the discrimination of current and former smokers from never smokers, where AUCs > 0.9 are regularly reported using a single CpG site (cg05575921; AHRR). However, there is a paucity of DNAm mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70419f159a251dcc993e64e169d7b24e
https://doi.org/10.1186/s13148-021-01191-6

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Autor: Katri Räikkönen, Marinus H. van IJzendoorn, Heather J. Zar, Nia McRae, Nour Baïz, Silvia Alemany, Andrea A. Baccarelli, Anni Malmberg, Robert O. Wright, Rosa H. Mulder, Gemma C Sharp, Darina Czamara, Charleen D. Adams, Christian M. Page, Samuli Tuominen, Marian J. Bakermans-Kranenburg, Isabella Annesi-Maesano, Maria C. Magnus, Nancy McBride, Jordi Sunyer, Caroline L Relton, Nastassja Koen, Ellen A. Nohr, Stephanie J. London, Siri E. Håberg, Elena Colicino, Marie-France Hivert, Charlotte A.M. Cecil, Eero Kajantie, Andrew Ratanatharathorn, Debbie A Lawlor, Rosalind J. Wright, John Wright, Kelly J. Brunst, Sheryl L. Rifas-Shiman, Dan J. Stein, Andrea P. Cortes Hidalgo, Jari Lahti, Thorkild I. A. Sørensen, Dawn L. DeMeo, Janine F. Felix, Paul Yousefi, Doretta Caramaschi, Jianping Jin, Martha María Téllez-Rojo, Giancarlo Pesce, Henning Tiemeier, Andres Cardenas, Lotte C Houtepen, Sara Sammallahti, Jonathan A Heiss

Publikováno v: Molecular Psychiatry, 26(6), 1832-1845. Nature Publishing Group
Mol Psychiatry
Sammallahti, S, Cortes Hidalgo, A P, Tuominen, S, Malmberg, A, Mulder, R H, Brunst, K J, Alemany, S, McBride, N S, Yousefi, P, Heiss, J A, McRae, N, Page, C M, Jin, J, Pesce, G, Caramaschi, D, Rifas-Shiman, S L, Koen, N, Adams, C D, Magnus, M C, Baïz, N, Ratanatharathorn, A, Czamara, D, Håberg, S E, Colicino, E, Baccarelli, A A, Cardenas, A, DeMeo, D L, Lawlor, D A, Relton, C L, Felix, J F, van IJzendoorn, M H, Bakermans-Kranenburg, M J, Kajantie, E, Räikkönen, K, Sunyer, J, Sharp, G C, Houtepen, L C, Nohr, E A, Sørensen, T I A, Téllez-Rojo, M M, Wright, R O, Annesi-Maesano, I, Wright, J, Hivert, M F, Wright, R J, Zar, H J, Stein, D J, London, S J, Cecil, C A M, Tiemeier, H & Lahti, J 2021, ' Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation ', Molecular Psychiatry, vol. 26, no. 6, pp. 1832-1845 . https://doi.org/10.1038/s41380-020-00976-0
Molecular Psychiatry
Sammallahti, S, Cortes Hidalgo, A P, Tuominen, S, Malmberg, A, Mulder, R H, Brunst, K J, Alemany, S, McBride, N S, Yousefi, P, Heiss, J A, McRae, N, Page, C M, Jin, J, Pesce, G, Caramaschi, D, Rifas-Shiman, S L, Koen, N, Adams, C D, Magnus, M C, Baiz, N, Ratanatharathorn, A, Czamara, D, Haberg, S E, Colicino, E, Baccarelli, A A, Cardenas, A, DeMeo, D L, Lawlor, D A, Relton, C L, Felix, J F, van IJzendoorn, M H, Bakermans-Kranenburg, M J, Kajantie, E, Raikkonen, K, Sunyer, J, Sharp, G C, Houtepen, L C, Nohr, E A, Sørensen, T I A, Tellez-Rojo, M M, Wright, R O, Annesi-Maesano, I, Wright, J, Hivert, M-F, Wright, R J, Zar, H J, Stein, D J, London, S J, Cecil, C A M, Tiemeier, H & Lahti, J 2021, ' Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation ', Molecular Psychiatry, vol. 26, pp. 1832–1845 . https://doi.org/10.1038/s41380-020-00976-0
et al. 2021, ' Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation ', Molecular Psychiatry, vol. 26, no. 6, pp. 1832-1845 . https://doi.org/10.1038/s41380-020-00976-0

Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501c836633282e2faeaa37262dbe74f8
https://pure.eur.nl/en/publications/851995bd-fafb-4475-adcb-3f64e7e98126