Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Paul, Wordsworth"'
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS
Externí odkaz:
https://doaj.org/article/4d44f030f3c647369f1e33e5b6cb95bb
Autor:
Chaofan Zhang, Angad Jolly, Brian J. Shayota, Juliana F. Mazzeu, Haowei Du, Moez Dawood, Patricia Celestino Soper, Ariadne Ramalho de Lima, Bárbara Merfort Ferreira, Zeynep Coban-Akdemir, Janson White, Deborah Shears, Fraser Robert Thomson, Sarah Louise Douglas, Andrew Wainwright, Kathryn Bailey, Paul Wordsworth, Mike Oldridge, Tracy Lester, Alistair D. Calder, Katja Dumic, Siddharth Banka, Dian Donnai, Shalini N. Jhangiani, Lorraine Potocki, Wendy K. Chung, Sara Mora, Hope Northrup, Myla Ashfaq, Jill A. Rosenfeld, Kati Mason, Lynda C. Pollack, Allyn McConkie-Rosell, Wei Kelly, Marie McDonald, Natalie S. Hauser, Peter Leahy, Cynthia M. Powell, Raquel Boy, Rachel Sayuri Honjo, Fernando Kok, Lucia R. Martelli, Vicente Odone Filho, Genomics England Research Consortium, Donna M. Muzny, Richard A. Gibbs, Jennifer E. Posey, Pengfei Liu, James R. Lupski, V. Reid Sutton, Claudia M.B. Carvalho
Publikováno v:
HGG Advances, Vol 3, Iss 1, Pp 100074- (2022)
Summary: Robinow syndrome (RS) is a genetically heterogeneous disorder with six genes that converge on the WNT/planar cell polarity (PCP) signaling pathway implicated (DVL1, DVL3, FZD2, NXN, ROR2, and WNT5A). RS is characterized by skeletal dysplasia
Externí odkaz:
https://doaj.org/article/111938d44884445f92d7831c96a453cf
Autor:
Carla J. Cohen, Connor Davidson, Carlo Selmi, Paul Bowness, Julian C. Knight, B. Paul Wordsworth, Matteo Vecellio
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Background: Ankylosing Spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex aetiology and high heritability, involving more than 100 genetic associations. These include several AS-associated single nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/4ff8b902deb44568b15837a082b96c85
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Ankylosing spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex polygenic aetiology. Genome-wide association studies have identified more than 100 loci, including some involved in antigen presentation (HLA-B27, ERAP1, and
Externí odkaz:
https://doaj.org/article/d3c870dd43c64d8bae022c064eced646
Autor:
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Psoriatic arthritis (PsA) is a chronic inflammatory disease belonging to the family of spondyloarthropathies (SpA). PsA commonly aggravates psoriasis of the skin and frequently manifests as an oligoarthritis with axial skeletal involvement and extraa
Externí odkaz:
https://doaj.org/article/b0f260f44f4c416083bc010764a76305
Autor:
Nicholas Dodds, Geldy Begenjev, Yevgeney Bezmenov, Christoph Gruetzner, Robert Mirzin, Edward Rhodes, Richard T. Walker, Paul Wordsworth
Publikováno v:
Bulletin of the Seismological Society of America. 112:2189-2215
The Main Köpetdag fault (MKDF) of Turkmenistan is one of the longest (≈500 km) and the most rapidly straining (9.1 ± 1.3 mm/yr) faults of the Arabia–Eurasia collision zone, and yet, in contrast to adjacent parts of Turkmenistan and Iran, it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0173fb352e8808383d1f01b0ef7b18
https://doi.org/10.1785/0120210195
https://doi.org/10.1785/0120210195
BackgroundMonoclonal antibodies against tumour necrosis factor (TNF) markedly reduce inflammation and disease activity in rheumatoid arthritis; however, the mechanisms through which they affect pain are not fully understood.AimsThe aim of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbdca821e250b1df622162e282e2f5e6
https://doi.org/10.1101/2023.02.27.23286245
https://doi.org/10.1101/2023.02.27.23286245
Autor:
Homa Tajsharghi, Kathryn Bailey, Katarina Ejeskär, Mehran Beiraghi Toosi, Mohammad Doosti, Ehsan Ghayoor Karimiani, A. Wainwright, Matteo P. Ferla, Benito Banos-Pinero, Alistair T. Pagnamenta, Jenny C. Taylor, Francisca Díaz-González, Reza Maroofian, Alistair Calder, Karen E. Heath, Deborah J. Shears, Paul Wordsworth, Tracy Lester
Publikováno v:
Journal of Medical Genetics. 59:947-950
The 100 000 Genomes Project (100KGP) is a UK-wide initiative that has a goal of using whole genome sequencing (WGS) to identify genetic causes of rare inherited diseases and embed the use of this technology within the NHS.1 Using data from this resou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c00483335ad7451391cca79a72d887f
https://doi.org/10.1136/jmedgenet-2021-108027
https://doi.org/10.1136/jmedgenet-2021-108027
Autor:
Ian Pierce, Ibrahim Guliyev, Gurban Jalal Yetirmishli, Rauf Muradov, Sabina Kazimova, Rashid Javanshir, Ben Johnson, Neill Marshall, Richard Thomas Walker, Paul Wordsworth
Quaternary convergence at rates of ~10 mm/yr between the Arabian and Eurasian plates is largely accommodated by the Kura fold-thrust belt at the longitude of the Greater Caucasus Mountains in Azerbaijan and eastern Georgia. Here we present the result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98d53fbd330e00ae1dc030d67c6f0dc
https://doi.org/10.22541/essoar.167152213.30022523/v1
https://doi.org/10.22541/essoar.167152213.30022523/v1
Publikováno v:
Antiquity
The expansion of the Umayyad and Abbasid Caliphates (seventh to ninth centuries AD) brought diverse regions from the Indus Valley to the Eurasian Steppe under hegemonic control. An overlooked aspect of this political process is the subsequent translo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c638063443ce459740d7c4f248fea45
https://doi.org/10.15184/aqy.2021.108
https://doi.org/10.15184/aqy.2021.108