Rituximab prophylaxis to prevent thrombotic thrombocytopenic purpura relapse: outcome and evaluation of dosing regimens

Autor: John-Paul Westwood, Mari Thomas, Ferras Alwan, Vickie McDonald, Sylvia Benjamin, William A. Lester, Gillian C. Lowe, Tina Dutt, Quentin A. Hill, Marie Scully

Publikováno v: Blood Advances, Vol 1, Iss 15, Pp 1159-1166 (2017)

Abstract: Acute antibody-mediated thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy with high morbidity and mortality. Rituximab is highly effective as prophylaxis in patients at risk of acute TTP relapse, but the ideal dosing

Externí odkaz: https://doaj.org/article/039675966e174eba8bed33687e100d8d

Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Autor: Chiara Vendramin, Mari Thomas, John-Paul Westwood, Marie Scully

Publikováno v: TH Open, Vol 02, Iss 03, Pp e329-e333 (2018)

A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (

Externí odkaz: https://doaj.org/article/cae5339a63394176bb9c2e2a2cb7536e

Delayed normalisation of ADAMTS13 activity in acute Thrombotic Thrombocytopenic Purpura in the caplacizumab era

Autor: Nithya Prasannan, Mari Thomas, Matthew James Stubbs, John-Paul Westwood, Rens de Groot, Deepak Singh, Marie Scully

Publikováno v: Blood.

The benefits of caplacizumab in acute immune mediated TTP (iTTP) are well established. We identified a delay in normalisation of ADAMTS13 activity (>30%) in a subgroup of caplacizumab treated patients which was not evident in the pre-caplacizumab era

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b0a0f3488da7e5eb027d49fe669078a
https://doi.org/10.1182/blood.2022018847

Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing

Autor: Lynne J, Hocking, Claire, Andrews, Christine, Armstrong, Morad, Ansari, David, Baty, Jonathan, Berg, Therese, Bradley, Caroline, Clark, Austin, Diamond, Jill, Doherty, Anne, Lampe, Ruth, McGowan, David J, Moore, Dawn, O'Sullivan, Andrew, Purvis, Javier, Santoyo-Lopez, Paul, Westwood, Michael, Abbott, Nicola, Williams, Timothy J, Aitman, Margo, Whiteford

Publikováno v: Hocking, L J, Andrews, C, Armstrong, C, Ansari, M, Baty, D, Berg, J, Bradley, T, Clark, C, Diamond, A, Doherty, J, Lampe, A, McGowan, R, Moore, D J, O'Sullivan, D, Purvis, A, Santoyo-Lopez, J, Westwood, P, Abbott, M, Williams, N & Aitman, T J & Miedzybrodzka, Z 2022, ' Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing ', European Journal of Human Genetics, vol. 31 . https://doi.org/10.1038/s41431-022-01226-3

NHS genetics centres in Scotland sought to investigate the Genomics England 100,000 Genomes Project diagnostic utility to evaluate genome sequencing for in rare, inherited conditions. Four regional services recruited 999 individuals from 394 families

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09a3b01751706f954ef04300960a4c0
https://pubmed.ncbi.nlm.nih.gov/36474026

The role of complement activation in COPD exacerbation recovery

Autor: John-Paul Westwood, Alexander J. Mackay, Gavin Donaldson, Samuel J. Machin, Jadwiga A. Wedzicha, Marie Scully

Publikováno v: ERJ Open Research, Vol 2, Iss 4 (2016)

Externí odkaz: https://doaj.org/article/520344025ad349d8ab54361582b7ea04