Výsledky vyhledávání - "Paul, Thorner"

Data from Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models

Autor: Sylvain Baruchel, Paul Thorner, Sushil Kumar, Bing Wu, Paula Marrano, Libo Zhang

Purpose: Tumor cells residing in tumor hypoxic zones are a major cause of drug resistance and tumor relapse. In this study, we investigated the efficacy of evofosfamide, a hypoxia-activated prodrug, and its combination with topotecan in neuroblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07351508b4508668b5075a69348822d4
https://doi.org/10.1158/1078-0432.c.6523467

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Supplementary Figure 1 from Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models

Autor: Sylvain Baruchel, Paul Thorner, Sushil Kumar, Bing Wu, Paula Marrano, Libo Zhang

Limited anti-tumor effects of ifosfamide in the CHLA-20 xenograft model. A total of 1 Ã- 106 CHLA-20 cells were implanted subcutaneously into SCID/SCID mice. Once tumors were palpable (about 0.25cm3), mice were randomized into vehicle control (n=6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a071d7a0b6c691b6454e89df746e4da
https://doi.org/10.1158/1078-0432.22456971.v1

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Supplementary Figure 2 from Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models

Autor: Sylvain Baruchel, Paul Thorner, Sushil Kumar, Bing Wu, Paula Marrano, Libo Zhang

Continued 3-day hypoxia does not increase cytotoxicity of evofosfamide compared to overnight hypoxia. A panel of two NBL cell lines (CHLA-20 and SK-N-BE(2)) and two rhabdomyosarcoma cell line (RH4 and RD) were selected to assess the effects of evofos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16526b7ebd613ad170f18291e283502
https://doi.org/10.1158/1078-0432.22456968

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Supplementary Figure 4 from Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models

Autor: Sylvain Baruchel, Paul Thorner, Sushil Kumar, Bing Wu, Paula Marrano, Libo Zhang

Topotecan enhanced intracellular ROS in rhabdomyosarcoma cells under hypoxia. Tumor cells were exposed different concentrations of evofosfamide overnight with or without the presence of topotecan (20nM). DCFDA assay was performed as described above.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260b7cff0e3e42c4ba963188763075a0
https://doi.org/10.1158/1078-0432.22456962

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Supplementary Figure 3 from Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models

Autor: Sylvain Baruchel, Paul Thorner, Sushil Kumar, Bing Wu, Paula Marrano, Libo Zhang

Increased ROS in neuroblastoma and rhabdomyosarcoma cells under hypoxia. The generation of intracellular oxidative activities was evaluated by measuring intracellular peroxide-dependent oxidation of 2â€²,7â€²-dichlorodihydrofluorescein diacet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57212d1027074dab21aea706fe0e4540
https://doi.org/10.1158/1078-0432.22456965

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Supplementary Figure 1 from Nab-Paclitaxel Is an Active Drug in Preclinical Model of Pediatric Solid Tumors

Autor: Sylvain Baruchel, Paul Thorner, Evelyn Elias, Michael Leadley, Sushil Kumar, Paula Marrano, Libo Zhang

PDF file - 229K, Supplementary Figure 1. Expression of SPARC and PTEN in neuroblastoma cell lines. SPARC and PTEN expression were assessed in a panel of eight neuroblastoma cell lines by Western Blot. For Western blot analysis, 50 microg protein was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282ddb7e26cbf4a01ef93ea41433315d
https://doi.org/10.1158/1078-0432.22449855

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Data from Nab-Paclitaxel Is an Active Drug in Preclinical Model of Pediatric Solid Tumors

Autor: Sylvain Baruchel, Paul Thorner, Evelyn Elias, Michael Leadley, Sushil Kumar, Paula Marrano, Libo Zhang

Purpose: To investigate the antitumor effect of nab-paclitaxel, an albumin-stabilized nanoparticle formulation of paclitaxel, on pediatric solid tumor models.Experimental Design: A panel of three rhabdomyosarcoma, one osteosarcoma and seven neuroblas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2647965ff8589bfd8147aab5682ad2
https://doi.org/10.1158/1078-0432.c.6521775

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