Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Paul, Schedl"'
Publikováno v:
eLife, Vol 13 (2024)
The chromosomes in multicellular eukaryotes are organized into a series of topologically independent loops called TADs. In flies, TADs are formed by physical interactions between neighboring boundaries. Fly boundaries exhibit distinct partner prefere
Externí odkaz:
https://doaj.org/article/9427adb529d84547857897ac73cfdcf2
Autor:
Xinyang Bing, Wenfan Ke, Miki Fujioka, Amina Kurbidaeva, Sarah Levitt, Mike Levine, Paul Schedl, James B Jaynes
Publikováno v:
eLife, Vol 13 (2024)
Two different models have been proposed to explain how the endpoints of chromatin looped domains (‘TADs’) in eukaryotic chromosomes are determined. In the first, a cohesin complex extrudes a loop until it encounters a boundary element roadblock,
Externí odkaz:
https://doaj.org/article/69f54650950e47cea510ecc8aa1663b4
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
Expression of Abdominal-B (Abd-B) in abdominal segments A5–A8 is controlled by four regulatory domains, iab-5–iab-8. Each domain has an initiator element (which sets the activity state), elements that maintain this state and tissue-specific enhan
Externí odkaz:
https://doaj.org/article/4c548cd22474454dbbd40f5d971fef11
Autor:
Airat Ibragimov, Xin Yang Bing, Yulii V Shidlovskii, Michael Levine, Pavel Georgiev, Paul Schedl
Publikováno v:
eLife, Vol 12 (2023)
Though long non-coding RNAs (lncRNAs) represent a substantial fraction of the Pol II transcripts in multicellular animals, only a few have known functions. Here we report that the blocking activity of the Bithorax complex (BX-C) Fub-1 boundary is seg
Externí odkaz:
https://doaj.org/article/ca2098d62893426ca25ca2f8e2f03e71
Publikováno v:
eLife, Vol 12 (2023)
In Drosophila melanogaster embryos, somatic versus germline identity is the first cell fate decision. Zygotic genome activation (ZGA) orchestrates regionalized gene expression, imparting specific identity on somatic cells. ZGA begins with a minor wav
Externí odkaz:
https://doaj.org/article/36455ee220944790b7983aeb1b8ef2b6
Autor:
Olga Kyrchanova, Vladimir Sokolov, Maxim Tikhonov, Galya Manukyan, Paul Schedl, Pavel Georgiev
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11368 (2023)
In higher eukaryotes, distance enhancer-promoter interactions are organized by topologically associated domains, tethering elements, and chromatin insulators/boundaries. While insulators/boundaries play a central role in chromosome organization, the
Externí odkaz:
https://doaj.org/article/c35676ceda2441ceb7d50e75679fe864
Autor:
Eugene N. Kozlov, Roman V. Deev, Elena V. Tokmatcheva, Anna Tvorogova, Zaur M. Kachaev, Rudolf A. Gilmutdinov, Mariya Zhukova, Elena V. Savvateeva-Popova, Paul Schedl, Yulii V. Shidlovskii
Publikováno v:
Cells, Vol 12, Iss 13, p 1717 (2023)
Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of n
Externí odkaz:
https://doaj.org/article/113e321edc534cb68cd76ede37f140a9
Autor:
Maksim Erokhin, Fedor Gorbenko, Dmitry Lomaev, Marina Yu Mazina, Anna Mikhailova, Azat K. Garaev, Aleksander Parshikov, Nadezhda E. Vorobyeva, Pavel Georgiev, Paul Schedl, Darya Chetverina
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Epigenetic memory plays a critical role in the establishment and maintenance of cell identities in multicellular organisms. Polycomb and trithorax group (PcG and TrxG) proteins are responsible for epigenetic memory, and in flies,
Externí odkaz:
https://doaj.org/article/e4285f8a2b8f40c3b7b36b3231e85665
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated
Externí odkaz:
https://doaj.org/article/dcf2151029b64d2c938dba1392c95331
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The autonomy of segment-specific regulatory domains in the Bithorax complex is conferred by boundary elements and associated Polycomb response elements (PREs). The Fab-6 boundary is located at the junction of the iab-5 and iab-6 domains. Pre
Externí odkaz:
https://doaj.org/article/de70deac060945e0821615270fc70e5c