Zobrazeno 1 - 10
of 1 259
pro vyhledávání: '"Paul, Rutgeerts"'
Publikováno v:
European Medical Journal Gastroenterology, Vol 4, Iss 1, Pp 58-65 (2015)
Ulcerative colitis (UC) carries a significant, progressive disease burden that is often underestimated or misinterpreted by healthcare providers. Adverse outcomes have a major impact on patient quality of life, with a significant burden of symptoms b
Externí odkaz:
https://doaj.org/article/d630731f97194a68b5192a8cfbd19c00
Autor:
Colleen Marano, Freddy Cornillie, Paul Rutgeerts, J Omoniyi Adedokun, Jean-Frederic Colombel, George Philip, Richard Melsheimer
Publikováno v:
Journal of Crohn's and Colitis. 13:1257-1264
Background and Aims In nonresponders to golimumab induction for ulcerative colitis, we assessed clinical response rates and golimumab serum concentrations when the 100-mg dose was used early in the course of maintenance. Methods This post-hoc analysi
Autor:
Sofie Berg, Jen-Fue Maa, Anne M. Robinson, J Petersson, Paul Rutgeerts, Stefan Schreiber, William J. Sandborn, Remo Panaccione, Jean-Frederic Colombel, Robert Löfberg
Publikováno v:
Journal of Crohn's & Colitis
Background and Aims Analyses of Crohn’s Disease [CD] studies of anti-TNF agents, including adalimumab, have reported higher remission rates among patients with shorter disease duration. To further explore the relationship between disease duration a
Autor:
Bram Verstockt, Severine Vermeire, Kathleen Machiels, Paul Rutgeerts, Ingrid Arijs, Jan Van der Goten, Leentje Van Lommel, Frans Schuit, Maaike Vancamelbeke, Marc Ferrante, Gert De Hertogh, Isabelle Cleynen, Gert Van Assche, Sare Verstockt
Publikováno v:
Journal of Crohn's and Colitis. 13:916-930
Background and Aims Early treatment of Crohn’s disease [CD] is required in order to optimize patient outcomes. To this end, we need to gain a better understanding of the molecular changes at the onset of CD. Methods As a model for the earliest muco
Autor:
Jan Van der Goten, Wiebe Vanhove, Katleen Lemaire, Leentje Van Lommel, Kathleen Machiels, Willem-Jan Wollants, Vicky De Preter, Gert De Hertogh, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Frans Schuit, Séverine Vermeire, Ingrid Arijs
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116117 (2014)
BACKGROUND: Ulcerative colitis (UC) is associated with differential colonic expression of genes involved in immune response (e.g. IL8) and barrier integrity (e.g. cadherins). MicroRNAs (miRNAs) are regulators of gene expression and are involved in va
Externí odkaz:
https://doaj.org/article/8f96cf5217e4464ca1f709df2d660cf1
Autor:
Karel Geboes, Paul Rutgeerts
Publikováno v:
Canadian Journal of Gastroenterology, Vol 13, Iss 8, Pp 671-678 (1999)
Dysplasia is a morphological term that ethymologically means ‘malformation’. For the definition of inflammatory bowel disease-related dysplasia, the nature and origin of the malformation are stressed and the lesion is defined as an epithelial mal
Externí odkaz:
https://doaj.org/article/a3e388a62a0c41b2b9007dce6f7d9f40
Autor:
Christine Breynaert, Tom Dresselaers, Clémentine Perrier, Ingrid Arijs, Jonathan Cremer, Leentje Van Lommel, Kristel Van Steen, Marc Ferrante, Frans Schuit, Séverine Vermeire, Paul Rutgeerts, Uwe Himmelreich, Jan L Ceuppens, Karel Geboes, Gert Van Assche
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68876 (2013)
INTRODUCTION: Chronically relapsing inflammation, tissue remodeling and fibrosis are hallmarks of inflammatory bowel diseases. The aim of this study was to investigate changes in connective tissue in a chronic murine model resulting from repeated cyc
Externí odkaz:
https://doaj.org/article/320431136fd349cba405ca1f73028adb
Autor:
Maureen J Koslowski, Zora Teltschik, Julia Beisner, Elke Schaeffeler, Guoxing Wang, Irmgard Kübler, Michael Gersemann, Rachel Cooney, Derek Jewell, Walter Reinisch, Séverine Vermeire, Paul Rutgeerts, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Externí odkaz:
https://doaj.org/article/56702dae105843a4a2280f10511cdf3f
Autor:
Gert De Hertogh, Bart Lemmens, Peter Verhasselt, Ronald de Hoogt, Xavier Sagaert, Marie Joossens, Gert Van Assche, Paul Rutgeerts, Severine Vermeire, Jeroen Aerssens
Publikováno v:
International Journal of Inflammation, Vol 2012 (2012)
The microbiota of the gastrointestinal tract is frequently mentioned as one of the key players in the etiopathogenesis of Crohn's disease (CD). Four hypotheses have been suggested: the single, still unknown bacterial pathogen, an abnormal overall com
Externí odkaz:
https://doaj.org/article/5f835aebd7d041de993f3ccae034e4ea
Autor:
Stephen B. Hanauer, Jewel Johanns, W J Sandborn, Jean-Frederic Colombel, Douglas Jacobstein, Brian G. Feagan, Christopher Gasink, W.J.S. de Villiers, S. R. Targan, Paul Rutgeerts, Bin Zou, Subrata Ghosh, Bruce E. Sands
Publikováno v:
Alimentary Pharmacology & Therapeutics
Summary Background In Phase 3 studies of ustekinumab, a fully human monoclonal IL‐12/23p40 antibody approved for moderate‐to‐severe Crohn's disease, patients entered a long‐term extension after completing 8 weeks of induction and 44 weeks of