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Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response

Autor: Ferry, Christine, Gaouar, Samia, Fischer, Benoit, Boeglin, Marcel, Paul, Nicodeme, Samarut, Eric, Piskunov, Aleksandr, Pankotai-Bodo, Gabriella, Brino, Laurent, Rochette-Egly, Cecile

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2011 Dec . 108(51), 20603-20608.

Externí odkaz: https://www.jstor.org/stable/23077292

A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1β as relevant therapy for gout patients

Autor: Mariotte, Alexandre, De Cauwer, Aurore, Po, Chrystelle, Abou-Faycal, Chérine, Pichot, Angélique, Paul, Nicodème, Aouadi, Ismael, Carapito, Raphael, Frisch, Benoit, Macquin, Cécile, Chatelus, Emmanuel, Sibilia, Jean, Armspach, Jean-Paul, Bahram, Seiamak, Georgel, Philippe

Publikováno v: Theranostics

Rationale: The role of Monosodium Urate (MSU) crystals in gout pathophysiology is well described, as is the major impact of IL-1β in the inflammatory reaction that constitutes the hallmark of the disease. However, despite the discovery of the NLRP3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2477ec4a5e8dc457fb77604b3771c6e1
http://europepmc.org/articles/PMC7019178

Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Autor: Murdamoothoo, Devadarssen, Sun, Zhen, Yilmaz, Alev, Riegel, Gilles, Abou-Faycal, Chérine, Deligne, Claire, Velazquez-Quesada, Ines, Erne, William, Nascimento, Marine, Morgelin, Matthias, Cremel, Gerard, Paul, Nicodème, Carapito, Raphaël, Veber, Romain, Dumortier, Hélène, Yuan, Jingping, Midwood, Kim, Loustau, Thomas, Orend, Gertraud

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 6, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2021, 13 (6), pp.e13270. ⟨10.15252/emmm.202013270⟩
EMBO Molecular Medicine, Wiley Open Access, 2021, 13 (6), ⟨10.15252/emmm.202013270⟩

Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ade4f0d32991c76adcac2605b701cb8b
https://doaj.org/article/b3b3bbcf9e5c4240a68764406229c8d2