Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paul, Moench"'
Publikováno v:
Bioanalysis. 13:1001-1010
With decommissioning of internal regulated bioanalytical (BA) and toxicokinetic (TK) capabilities, Novartis has relied on external service providers (ESPs) for all nonclinical LC–MS BA and majority of the associated TK work since 2017. This paper o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05a888111ed3a51969227f933b5bc08
https://doi.org/10.4155/bio-2021-0072
https://doi.org/10.4155/bio-2021-0072
Publikováno v:
Journal of Chromatography B. :117-124
A high-performance liquid chromatography–tandem mass spectrometric (LC–MS/MS) method has been developed and validated for the quantitative analysis of loratadine, an H1 histamine antagonist, in human dried blood spot (DBS) samples following a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f6cc344e6f6ba7f6124537bd1ce8f4
https://doi.org/10.1016/j.jchromb.2014.12.033
https://doi.org/10.1016/j.jchromb.2014.12.033
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:340-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b47cdfb8d52a6016b472818fc8d8096
https://doi.org/10.1002/rcm.7441
https://doi.org/10.1002/rcm.7441
Autor:
John E. Macor, Chaturvedula Prasad, Rex Denton, Gene M. Dubowchik, Paul Moench, Valerie J. Whiterock, Charlie M. Conway, Cen Xu, Neil Mathias, Glenn H. Cantor, Robert Macci, Richard Schartman, Laura J. Signor, Stephen E. Mercer, George Thalody, Carl D. Davis, Deborah Keavy, Sokhom S. Pin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3157-3161
Calcitonin gene-related peptide (CGRP) receptor antagonists have been shown to be efficacious as abortive migraine therapeutics with the absence of cardiovascular liabilities that are associated with triptans. Herein, we report the discovery of a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ac514e0ff9910e3b128930ebdf5765
https://doi.org/10.1016/j.bmcl.2013.04.012
https://doi.org/10.1016/j.bmcl.2013.04.012
Autor:
George Thalody, Paul Moench, Valerie J. Whiterock, Deborah A. Cook, Charles M. Conway, Xiang-Jun Jiang, Laura J. Signor, Neil Mathias, Richard Schartman, Carl D. Davis, Cen Xu, Robert Macci, Xiaojun Han, George O. Tora, Sokhom S. Pin, John E. Macor, Gene M. Dubowchik, Andrew P. Degnan, Rita L. Civiello
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1870-1873
Various substituted indazole and benzoxazolone amino acids were investigated as d -tyrosine surrogates in highly potent CGRP receptor antagonists. Compound 3, derived from the 7-methylindazole core, afforded a 30-fold increase in CGRP binding potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efad766cca18838d811178ca1ce78b8
https://doi.org/10.1016/j.bmcl.2013.01.011
https://doi.org/10.1016/j.bmcl.2013.01.011
Autor:
Xiaojun Ren, Jason Sarber, Keith Mansfield, Adam Bentley, Jimmy Flarakos, Upendra A. Argikar, Joyce Judge, Luis Ramos, Guiqing Liang, Xiao-Hui Chen, Adam Amaral, Paul Moench, Jim Glick, Alexandre Catoire, David Carcache, Panos Hatsis, Samuel Hintermann
Publikováno v:
Analytical chemistry. 88(23)
Surface sampling micro liquid chromatography tandem mass spectrometry (SSμLC-MS/MS) was explored as a quantitative tissue distribution technique for probing compound properties in drug discovery. A method was developed for creating standard curves u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58185282ba3c39329e235050ac103c88
https://pubmed.ncbi.nlm.nih.gov/27797491
https://pubmed.ncbi.nlm.nih.gov/27797491
Autor:
Neil Mathias, Sokhom S. Pin, Xiaojun Han, Paul Moench, John E. Macor, Richard Schartman, Charles M. Conway, Chaturvedula Prasad, Rex Denton, Kimberly A. Widmann, Laura J. Signor, Gene M. Dubowchik, Deborah A. Cook, Andrew P. Degnan, George Thalody, Robert Macci, Carl D. Davis, Shelly X. Ren, Cen Xu
Publikováno v:
Journal of Medicinal Chemistry. 51:4858-4861
Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Early chemistry leads suffered from modest potency, significant CYP3A4 inhibition, and poor aqueous solubility. Herein, we describe the optimization of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa440795b5aa2edcd0d1f4a3cb63ab67
https://doi.org/10.1021/jm800546t
https://doi.org/10.1021/jm800546t
Autor:
Munir A. Hussain, Ronald L. Smith, Doris A. Wall, Paul Moench, Christopher L. Heran, Neil Mathias, Paul Stetsko
Publikováno v:
Journal of Pharmaceutical Sciences. 92:1735-1738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80f0a497c1ffdd97b943f8308caf71c
https://doi.org/10.1002/jps.10436
https://doi.org/10.1002/jps.10436
Autor:
Vilmos Kertesz, Jimmy Flarakos, Alexandre Catoire, Gary J. Van Berkel, Paul Moench, Nithya Paranthaman
Publikováno v:
Bioanalysis. 6(19)
Background: The aim of this work was to evaluate the analytical performance of a fully automated droplet-based surface-sampling system for determining the distribution of the drugs acetaminophen and terfenadine, and their metabolites, in rat thin tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036d5e7986039a3909d40a6078e9ac60
https://pubmed.ncbi.nlm.nih.gov/25411703
https://pubmed.ncbi.nlm.nih.gov/25411703
Autor:
Sridhar Desikan, Munir A. Hussain, Ronald L. Smith, Neil Mathias, Feng Qian, Cecilia Chi, Paul Moench
Publikováno v:
International journal of pharmaceutics. 366(1-2)
Alternate delivery route of therapeutic peptides is an attractive non-invasive option to patients who must chronically self-administer their medication through injections. In recent years, much attention has centered on pulmonary peptide delivery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34907c8adc7563175a67aa7d8c0046a
https://pubmed.ncbi.nlm.nih.gov/19027057
https://pubmed.ncbi.nlm.nih.gov/19027057