Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Paul, McVeigh"'
Autor:
Christopher McFarland, Emer McCann, Peter McCann, Eric R. Morgan, Nikki J. Marks, Paul McVeigh, Geoffrey N. Gobert
Publikováno v:
Environmental DNA, Vol 6, Iss 5, Pp n/a-n/a (2024)
ABSTRACT Parasite transmission occurs in complex environments comprising multiple matrices. Trematode parasites of ruminant livestock such as the liver fluke, Fasciola hepatica and the rumen fluke, Calicophoron daubneyi, show affinity with freshwater
Externí odkaz:
https://doaj.org/article/9b549d675f81497e84184f16691cb919
Autor:
Paul McVeigh, Erin McCammick, Emily Robb, Peter Brophy, Russell M Morphew, Nikki J Marks, Aaron G Maule
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011663 (2023)
Long non-coding (lnc)RNAs are a class of eukaryotic RNA that do not code for protein and are linked with transcriptional regulation, amongst a myriad of other functions. Using a custom in silico pipeline we have identified 6,436 putative lncRNA trans
Externí odkaz:
https://doaj.org/article/32c1dce9cf28411a925bd0b75c16be4c
Autor:
Emily Robb, Erin M McCammick, Duncan Wells, Paul McVeigh, Erica Gardiner, Rebecca Armstrong, Paul McCusker, Angela Mousley, Nathan Clarke, Nikki J Marks, Aaron G Maule
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010854 (2022)
Fasciola spp. liver flukes have significant impacts in veterinary and human medicine. The absence of a vaccine and increasing anthelmintic resistance threaten sustainable control and underscore the need for novel flukicides. Functional genomic approa
Externí odkaz:
https://doaj.org/article/942dd2f73db1407ab6c0e8a48ec46440
Autor:
Bethany A. Crooks, Darrin Mckenzie, Luke C. Cadd, Ciaran J. McCoy, Paul McVeigh, Nikki J. Marks, Aaron G. Maule, Angela Mousley, Louise E. Atkinson
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The endocannabinoid signalling (ECS) system is a complex lipid signalling pathway that modulates diverse physiological processes in both vertebrate and invertebrate systems. In nematodes, knowledge of endocannabinoid (EC) biology is derived primarily
Externí odkaz:
https://doaj.org/article/9c5accc957de4090a4409b0b7fdf9cd0
Autor:
Paul McCusker, Wasim Hussain, Paul McVeigh, Erin McCammick, Nathan G. Clarke, Emily Robb, Fiona M. McKay, Peter M. Brophy, David J. Timson, Angela Mousley, Nikki J. Marks, Aaron G. Maule
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 46-55 (2020)
For over a decade RNA interference (RNAi) has been an important molecular tool for functional genomics studies in parasitic flatworms. Despite this, our understanding of RNAi dynamics in many flatworm parasites, such as the temperate liver fluke (Fas
Externí odkaz:
https://doaj.org/article/6adc572dca29437098a0058fa1081fd4
Autor:
Caoimhe M. Herron, Anna O’Connor, Emily Robb, Erin McCammick, Claire Hill, Nikki J. Marks, Mark W. Robinson, Aaron G. Maule, Paul McVeigh
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The liver fluke, Fasciola hepatica, is a global burden on the wellbeing and productivity of farmed ruminants, and a zoonotic threat to human health. Despite the clear need for accelerated discovery of new drug and vaccine treatments for this pathogen
Externí odkaz:
https://doaj.org/article/8fed6352ef33460a8b762cb901beaf7b
Autor:
Louise E. Atkinson, Ciaran J. McCoy, Bethany A. Crooks, Fiona M. McKay, Paul McVeigh, Darrin McKenzie, Allister Irvine, John Harrington, Bruce A. Rosa, Makedonka Mitreva, Nikki J. Marks, Aaron G. Maule, Angela Mousley
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Nematode parasites undermine human health and global food security. The frontline anthelmintic portfolio used to treat parasitic nematodes is threatened by the escalation of anthelmintic resistance, resulting in a demand for new drug targets for para
Externí odkaz:
https://doaj.org/article/8a21f17362a64b8da5c79e86ac91e8cd
Autor:
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J. Marks, Aaron G. Maule
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 87-103 (2018)
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards
Externí odkaz:
https://doaj.org/article/6c49fc116d124b2ca6df6512d296b7ea
Autor:
Paul McVeigh, Aaron G Maule
Publikováno v:
eLife, Vol 8 (2019)
The first reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these dangerous human parasites.
Externí odkaz:
https://doaj.org/article/0fcbba1b92cb497abe651c100a6a04b4
Autor:
Paul McVeigh, Erin McCammick, Emily Robb, Peter Brophy, Russell M Morphew, Nikki J Marks, Aaron G Maule
Long non-coding (lnc)RNAs are a class of eukaryotic RNA that do not code for protein and are linked with transcriptional regulation, amongst a myriad of other functions. Using a customin silicopipeline we have identified 6,436 putative lncRNA transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766d2a709f45c0ead18fb78d7e85bc5a
https://doi.org/10.1101/2023.03.07.531498
https://doi.org/10.1101/2023.03.07.531498
