Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Paul, Hasty"'
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
Autor:
Mi Young Son, Ondrej Belan, Mario Spirek, Jakub Cibulka, Fedor Nikulenkov, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Cristina Montagna, Tae Moon Kim, Lumir Krejci, Paul Hasty
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109524- (2024)
Summary: Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the BRC repeats to form filaments on single-stranded DNA and exon 27 (E
Externí odkaz:
https://doaj.org/article/9292610b2dda480b8b8912a6757729c2
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113637- (2024)
Summary: TREX2, a 3′-5′ exonuclease, is a part of the DNA damage tolerance (DDT) pathway that stabilizes replication forks (RFs) by ubiquitinating PCNA along with the ubiquitin E3 ligase RAD18 and other DDT factors. Mismatch repair (MMR) corrects
Externí odkaz:
https://doaj.org/article/668be8cc974341a1a9bbc18f90cf34e9
Autor:
Mi Young Son, Paul Hasty
Publikováno v:
AIMS Genetics, Vol 5, Iss 4, Pp 192-211 (2019)
Homologous recombination (HR) repairs DNA double strand breaks (DSBs) and stabilizes replication forks (RFs). RAD51 is the recombinase for the HR pathway. To preserve genomic integrity, RAD51 forms a filament on the 3’ end of a DSB and on a single-
Externí odkaz:
https://doaj.org/article/bef9e6e50a834ef78146ef3aac7f9add
Autor:
Paul Hasty
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with diffe
Externí odkaz:
https://doaj.org/article/a99ddbd2c11a493f94b5935b8d9221b6
Autor:
Ja-Hwan Seol, Cory Holland, Xiaolei Li, Christopher Kim, Fuyang Li, Melisa Medina-Rivera, Robin Eichmiller, Ignacio F. Gallardo, Ilya J. Finkelstein, Paul Hasty, Eun Yong Shim, Jennifer A. Surtees, Sang Eun Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The yeast Rad1–Rad10 complex has multiple roles in DNA damage repair. Here the authors uncover mutants that uncouple the roles in UV excision repair and non-NER functions.
Externí odkaz:
https://doaj.org/article/1aa8a55b041d446c9bd15181548a0127
Autor:
Tyler J. Curiel, Zelton D. Sharp, Paul Hasty, Aijie Liu, Danielle Callaway, Sherry Dodds, Vincent Hurez, Yang Liu, Srilakshmi Pandeswara, Vinh Dao
Supplemental Figures S1-4. Supplementary Figure S1: eRapa prevents DMBA/TPA-induced dermal neoplasia and malignant degeneration in WT mice. Supplementary Figure S2: eRapa does not suppress mTORC1 signaling in whole skin. Supplementary Figure S3: eRap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7453c631c77c0d313ebdf28d200925e4
https://doi.org/10.1158/1940-6207.22527012.v1
https://doi.org/10.1158/1940-6207.22527012.v1
Autor:
Zelton Dave Sharp, Tyler J. Curiel, Vincent Hurez, Lishi Sun, Gene Hubbard, Kruthi Murthy, Lauren Sloane, Kathleen E. Fischer, Martin Javors, Randy Strong, Diane Jones, Sherry G. Dodds, Carolina B. Livi, Paul Hasty
Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk for colon cancer. ApcMin/+ mice exhibit multiple intestinal neoplasia (MIN) that causes anemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddf0634f81327f10016a3b4b0ab3b7c
https://doi.org/10.1158/1940-6207.c.6544299.v1
https://doi.org/10.1158/1940-6207.c.6544299.v1
Autor:
Zelton Dave Sharp, Tyler J. Curiel, Vincent Hurez, Lishi Sun, Gene Hubbard, Kruthi Murthy, Lauren Sloane, Kathleen E. Fischer, Martin Javors, Randy Strong, Diane Jones, Sherry G. Dodds, Carolina B. Livi, Paul Hasty
MOV file - 3205K, Three ApcMIn/+ 42 ppm eRapa-fed female mice at 902 days of age.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c901cc39e6c6571da6568f96b8c118f
https://doi.org/10.1158/1940-6207.22524540.v1
https://doi.org/10.1158/1940-6207.22524540.v1
Autor:
Zelton Dave Sharp, Tyler J. Curiel, Vincent Hurez, Lishi Sun, Gene Hubbard, Kruthi Murthy, Lauren Sloane, Kathleen E. Fischer, Martin Javors, Randy Strong, Diane Jones, Sherry G. Dodds, Carolina B. Livi, Paul Hasty
AVI file - 9806K, A 42 ppm-fed ApcMin/+ female at 1087 days of age.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1323bcee65144d2338d836bc2011e2
https://doi.org/10.1158/1940-6207.22524537.v1
https://doi.org/10.1158/1940-6207.22524537.v1
Autor:
Paul Hasty, Thomas Ried, Hesed Padilla-Nash, Sheng-Mei Ma, Danny Wangsa, Lavinia C. Dumitrache, Ming-Jiu Chen
Supplementary Table 1 from Cisplatin Depletes TREX2 and Causes Robertsonian Translocations as Seen in TREX2 Knockout Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04091477dc55286b2c225351fb7e7c68
https://doi.org/10.1158/0008-5472.22371687
https://doi.org/10.1158/0008-5472.22371687