Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Paul, Guichard"'
Autor:
Yvan Arsenijevic, Ning Chang, Olivier Mercey, Younes El Fersioui, Hanna Koskiniemi-Kuendig, Caroline Joubert, Alexis-Pierre Bemelmans, Carlo Rivolta, Eyal Banin, Dror Sharon, Paul Guichard, Virginie Hamel, Corinne Kostic
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 805-822 (2024)
Abstract For 15 years, gene therapy has been viewed as a beacon of hope for inherited retinal diseases. Many preclinical investigations have centered around vectors with maximal gene expression capabilities, yet despite efficient gene transfer, minim
Externí odkaz:
https://doaj.org/article/2bace1c6d9974dd18283e0facc8d9d6c
Autor:
Vincent Louvel, Romuald Haase, Olivier Mercey, Marine H. Laporte, Thibaut Eloy, Étienne Baudrier, Denis Fortun, Dominique Soldati-Favre, Virginie Hamel, Paul Guichard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Expansion microscopy (ExM) is a highly effective technique for super-resolution fluorescence microscopy that enables imaging of biological samples beyond the diffraction limit with conventional fluorescence microscopes. Despite the developme
Externí odkaz:
https://doaj.org/article/c6a6a3bb5cfb4d21a6b92a1f7f57c8cd
Autor:
Jana Muroňová, Zine Eddine Kherraf, Elsa Giordani, Emeline Lambert, Simon Eckert, Caroline Cazin, Amir Amiri-Yekta, Magali Court, Geneviève Chevalier, Guillaume Martinez, Yasmine Neirijnck, Francoise Kühne, Lydia Wehrli, Nikolai Klena, Virginie Hamel, Lisa De Macedo, Jessica Escoffier, Paul Guichard, Charles Coutton, Selima Fourati Ben Mustapha, Mahmoud Kharouf, Anne-Pacale Bouin, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Stefan Geimer, Corinne Loeuillet, Pierre F Ray, Christophe Arnoult
Publikováno v:
eLife, Vol 12 (2024)
From a cohort of 167 infertile patients suffering from multiple morphological abnormalities of the flagellum (MMAF), pathogenic bi-allelic mutations were identified in the CCDC146 gene. In somatic cells, CCDC146 is located at the centrosome and at mu
Externí odkaz:
https://doaj.org/article/078af173188c4adb858332ae057a3a05
Publikováno v:
Bio-Protocol, Vol 13, Iss 17 (2023)
Expansion microscopy is an innovative method that enables super-resolution imaging of biological materials using a simple confocal microscope. The principle of this method relies on the physical isotropic expansion of a biological specimen cross-link
Externí odkaz:
https://doaj.org/article/ac95c30245e140c6a3aad894ac038165
Autor:
Siebren Faber, Olivier Mercey, Katrin Junger, Alejandro Garanto, Helen May-Simera, Marius Ueffing, Rob W.J. Collin, Karsten Boldt, Paul Guichard, Virginie Hamel, Ronald Roepman
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Leber congenital amaurosis (LCA) is a group of inherited retinal diseases characterized by early-onset, rapid loss of photoreceptor cells. Despite the discovery of a growing number of genes associated with this disease, the molecular mechanisms of ph
Externí odkaz:
https://doaj.org/article/a2bc26897c2d4afd9e4c1af09072289e
Autor:
Pierrick Le Borgne, Logan Greibill, Marine Hélène Laporte, Michel Lemullois, Khaled Bouhouche, Mebarek Temagoult, Olivier Rosnet, Maeva Le Guennec, Laurent Lignières, Guillaume Chevreux, France Koll, Virginie Hamel, Paul Guichard, Anne-Marie Tassin
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001782 (2022)
In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface, and docking to the plasma membrane. Basal body docking involves the interaction of both the distal end of the basal b
Externí odkaz:
https://doaj.org/article/3d9991fd38074a048b2056a9dbbcee89
Autor:
Olivier Mercey, Corinne Kostic, Eloïse Bertiaux, Alexia Giroud, Yashar Sadian, David C A Gaboriau, Ciaran G Morrison, Ning Chang, Yvan Arsenijevic, Paul Guichard, Virginie Hamel
Publikováno v:
PLoS Biology, Vol 20, Iss 6, p e3001649 (2022)
Inherited retinal degeneration due to loss of photoreceptor cells is a leading cause of human blindness. These cells possess a photosensitive outer segment linked to the cell body through the connecting cilium (CC). While structural defects of the CC
Externí odkaz:
https://doaj.org/article/324b3bd946084b33b93c62af5b632046
Autor:
Fabian U. Zwettler, Sebastian Reinhard, Davide Gambarotto, Toby D. M. Bell, Virginie Hamel, Paul Guichard, Markus Sauer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Previous attempts to combine expansion microscopy (ExM) and single molecule localisation microscopy (SMLM) have proved challenging. Here the authors show that post-labelling Ex-SMLM improves labelling efficiency, reduces linkage error, and preserves
Externí odkaz:
https://doaj.org/article/138518bbdfb845248b9023cf52af2865
Autor:
Eloïse Bertiaux, Aurélia C Balestra, Lorène Bournonville, Vincent Louvel, Bohumil Maco, Dominique Soldati-Favre, Mathieu Brochet, Paul Guichard, Virginie Hamel
Publikováno v:
PLoS Biology, Vol 19, Iss 9, p e3001401 (2021)
[This corrects the article DOI: 10.1371/journal.pbio.3001020.].
Externí odkaz:
https://doaj.org/article/cc2d9811dd6f4a71b703c3d7d865456f
Publikováno v:
médecine/sciences. 39:351-358
La plupart des techniques d’imagerie cellulaire, telles que la microscopie photonique ou la microscopie électronique, nécessitent que l’échantillon biologique soit préalablement fixé par des agents chimiques, une étape qui est connue pour e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8e65167d4c96b13bb6ff4700cf2152a
https://doi.org/10.1051/medsci/2023052
https://doi.org/10.1051/medsci/2023052