Zobrazeno 1 - 10
of 965
pro vyhledávání: '"Paul, Greengard"'
Autor:
Lucile Marion-Poll, Jean-Pierre Roussarie, Lieng Taing, Cloelia Dard-Dascot, Nicolas Servant, Yan Jaszczyszyn, Emmanuelle Jordi, Eskeatnaf Mulugeta, Denis Hervé, Déborah Bourc’his, Paul Greengard, Claude Thermes, Jean-Antoine Girault
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Striatal projection neurons expressing the D1 or D2 dopamine receptors are probed for translating mRNAs and DNA modifications, identifying differential methylation signatures between the cell types and genome-wide hydroxymethylation asymmetry between
Externí odkaz:
https://doaj.org/article/fbba041371de4c2e84d3e2b2867fbc3e
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Hernandez Moura Silva, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247680 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0237773.].
Externí odkaz:
https://doaj.org/article/21d1f6bb95a349debe03d947808fbc31
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Externí odkaz:
https://doaj.org/article/d4ab345b9e074e9b86f224c51554c19b
Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements
Autor:
Leila Pirhaji, Pamela Milani, Simona Dalin, Brook T. Wassie, Denise E. Dunn, Robert J. Fenster, Julian Avila-Pacheco, Paul Greengard, Clary B. Clish, Myriam Heiman, Donald C. Lo, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulat
Externí odkaz:
https://doaj.org/article/ec0af8273fb342fcbf9ccadba0111a01
Autor:
Victor Hugo Bustos, Yashoda Krishna Sunkari, Anjana Sinha, Maria Pulina, Ashley Bispo, Maya Hopkins, Alison Lam, Sydney F. Kriegsman, Emily Mui, Emily Chang, Ana Jedlicki, Hannah Rosenthal, Marc Flajolet, Paul Greengard, Subhash C. Sinha
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ), C99, and Tau in vulnerable areas of the brain. Despite extensive research, current strategies to lower Aβ levels have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b996c2596047e1f36028280741db2409
https://doi.org/10.1101/2023.04.28.538773
https://doi.org/10.1101/2023.04.28.538773
Autor:
Thomas Liebmann, Nicolas Renier, Karima Bettayeb, Paul Greengard, Marc Tessier-Lavigne, Marc Flajolet
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1138-1152 (2016)
Amyloidosis is a major problem in over one hundred diseases, including Alzheimer’s disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation i
Externí odkaz:
https://doaj.org/article/81cb50cfb7834fee86952e0d56ff1f3f
Autor:
Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C. Nairn, Paul Greengard, Marc Flajolet, Denis Hervé, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Girault
Publikováno v:
bioRxiv
BACKGROUNDHighly palatable food triggers behavioral alterations reminiscent of those induced by addictive drugs. These effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (NAc). The molecular mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b0a4054ca07d7ddb52d40f19f36456
https://doi.org/10.1101/2023.03.07.531496
https://doi.org/10.1101/2023.03.07.531496
Autor:
Ran Zhang, Margarete Knudsen, Pedro Del Cioppo Vasques, Alicja Tadych, Patricia Rodriguez-Rodriguez, Paul Greengard, Jean-Pierre Roussarie, Ana Milosevic, Olga Troyanskaya
Astrocytes have been shown to play a central role in Alzheimer’s Disease (AD). However, the genes and biological pathways underlying disease manifestation are unknown, and it is unclear whether regional molecular differences among astrocytes contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf5e1b419aaaa25dfa79b689263c2da
https://doi.org/10.1101/2022.11.16.515390
https://doi.org/10.1101/2022.11.16.515390
Autor:
Veronica Musante, Lu Li, Jean Kanyo, Tukiet T Lam, Christopher M Colangelo, Shuk Kei Cheng, A Harrison Brody, Paul Greengard, Nicolas Le Novère, Angus C Nairn
Publikováno v:
eLife, Vol 6 (2017)
ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A
Externí odkaz:
https://doaj.org/article/1c6cbe02d5e743ca833ba86d9c17d590
Publikováno v:
Molecular Psychiatry
The delayed behavioral response to chronic antidepressants depends on dynamic changes in the hippocampus. It was suggested that the antidepressant protein p11 and the chromatin remodeling factor SMARCA3 mediate this delayed response by inducing trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfe86cf2c0ef5d2b57a4d33c68ecf31
https://doi.org/10.1038/s41380-021-01059-4
https://doi.org/10.1038/s41380-021-01059-4