Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Paul, Bertone"'
Autor:
Navneet Singh, Carsten Eickhoff, Augusto Garcia-Agundez, Paul Bertone, Sunita S. Paudel, Dhananjay T. Tambe, Leslie A. Litzky, Katherine Cox-Flaherty, James R. Klinger, Sean F. Monaghan, Christopher J. Mullin, Mandy Pereira, Thomas Walsh, Mary Whittenhall, Troy Stevens, Elizabeth O. Harrington, Corey E. Ventetuolo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes,
Externí odkaz:
https://doaj.org/article/fe02a15d8bc348fbaf794a7a71a2d29c
Autor:
Max Petersen, Anna Chorzalska, Makayla Pardo, Anaelena Rodriguez, John Morgan, Nagib Ahsan, Ting C. Zhao, Olin Liang, Leszek Kotula, Paul Bertone, Philip A. Gruppuso, Patrycja M. Dubielecka
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2356-2379 (2023)
Dysregulation of the adaptor protein Abelson interactor 1 (ABI1) is linked to malignant transformation. To interrogate the role of ABI1 in cancer development, we mapped the ABI1 interactome using proximity‐dependent labeling (PDL) with biotin follo
Externí odkaz:
https://doaj.org/article/9feb2424ca384d45925ebb57c2e9eae4
Autor:
Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, William Mansfield, Paul Bertone, Kristian Franze, José C. R. Silva, Kevin J. Chalut
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The independent control of substrate stiffness and tethering of extracellular matrix to substrates for mechanical signalling investigations remains challenging. Here the authors present StemBond hydrogels, with stable ECM tethering that can be varied
Externí odkaz:
https://doaj.org/article/2711320dd2f24be2b2c8cdd0355b3ae1
Autor:
Kathryn C. Tremble, Giuliano G. Stirparo, Lawrence E. Bates, Katsiaryna Maskalenka, Hannah T. Stuart, Kenneth Jones, Amanda Andersson-Rolf, Aliaksandra Radzisheuskaya, Bon-Kyoung Koo, Paul Bertone, José C.R. Silva
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102153- (2021)
Summary: Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-
Externí odkaz:
https://doaj.org/article/0ba31fc74d5742b49d4349e5fd86f383
Autor:
Ge Guo, Ferdinand von Meyenn, Fatima Santos, Yaoyao Chen, Wolf Reik, Paul Bertone, Austin Smith, Jennifer Nichols
Publikováno v:
Stem Cell Reports, Vol 6, Iss 4, Pp 437-446 (2016)
Conventional generation of stem cells from human blastocysts produces a developmentally advanced, or primed, stage of pluripotency. In vitro resetting to a more naive phenotype has been reported. However, whether the reset culture conditions of selec
Externí odkaz:
https://doaj.org/article/dffb88be6d4f4f50b7ef44d64e28f6ae
Autor:
Helena Carén, Stefan H. Stricker, Harry Bulstrode, Sladjana Gagrica, Ewan Johnstone, Thomas E. Bartlett, Andrew Feber, Gareth Wilson, Andrew E. Teschendorff, Paul Bertone, Stephan Beck, Steven M. Pollard
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 829-842 (2015)
Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stem cell-like cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stem cells (GSCs) and, therefore, might have therapeutic value. However, the epigenetic
Externí odkaz:
https://doaj.org/article/018195e881b74e3099bb5cf8e7096814
Autor:
Praveen Srinivasan, Benedito A. Carneiro, Andre De Souza, Luke B. Soliman, Wafik S. El-Deiry, Matthew Danish, Paul Bertone
Publikováno v:
American Journal of Clinical Oncology. 44:374-382
The development of androgen resistance in advanced prostate cancer remains a challenging clinical problem. Because androgen deprivation therapy constitutes the backbone of first-line treatments for metastatic prostate cancer, the phenotypic switch fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a58fa2dca19fbebc03d3742034e8e44
https://doi.org/10.1097/coc.0000000000000829
https://doi.org/10.1097/coc.0000000000000829
Autor:
Benjamin Krusche, Cristina Ottone, Melanie P Clements, Ewan R Johnstone, Katrin Goetsch, Huang Lieven, Silvia G Mota, Poonam Singh, Sanjay Khadayate, Azhaar Ashraf, Timothy Davies, Steven M Pollard, Vincenzo De Paola, Federico Roncaroli, Jorge Martinez-Torrecuadrada, Paul Bertone, Simona Parrinello
Publikováno v:
eLife, Vol 5 (2016)
Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive progression and recurrence. Diffuse invasion of the brain parenchyma, incl
Externí odkaz:
https://doaj.org/article/99e030f6989e4de2bac103b0da9fd5ea
Autor:
Bao Xiu Tan, Céline Labouesse, Carla Mulas, Alexander K. Winkel, Moritz Hofer, Christophe M. Verstreken, Chibeza C. Agley, Kevin J. Chalut, José C. R. Silva, Giuliano Giuseppe Stirparo, Paul Bertone, Kristian Franze, William Mansfield, Hannah T. Stuart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Funder: Medical Research Council (UK) Career Development Award (G1100312/1)
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db56a2eb87774cd06d0a784eb5336e
https://www.repository.cam.ac.uk/handle/1810/329719
https://www.repository.cam.ac.uk/handle/1810/329719
Autor:
Luke, Soliman, Andre, De Souza, Praveen, Srinivasan, Matthew, Danish, Paul, Bertone, Wafik S, El-Deiry, Benedito A, Carneiro
Publikováno v:
American journal of clinical oncology. 44(7)
The development of androgen resistance in advanced prostate cancer remains a challenging clinical problem. Because androgen deprivation therapy constitutes the backbone of first-line treatments for metastatic prostate cancer, the phenotypic switch fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0edc77234d1702ce7fdf341f2a3ee693
https://pubmed.ncbi.nlm.nih.gov/34014842
https://pubmed.ncbi.nlm.nih.gov/34014842