Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis

Autor: Wenbo Zhou, Michael Graner, Petr Paucek, Cheryl Beseler, Matthew Boisen, Andrew Bubak, Francisco Asturias, Woro George, Arin Graner, David Ormond, Timothy Vollmer, Enrique Alvarez, Xiaoli Yu

Publikováno v: Cell Death and Disease, Vol 14, Iss 4, Pp 1-12 (2023)

Abstract Grey matter pathology is central to the progression of multiple sclerosis (MS). We discovered that MS plasma immunoglobulin G (IgG) antibodies, mainly IgG1, form large aggregates (>100 nm) which are retained in the flow-through after binding

Externí odkaz: https://doaj.org/article/569999a6198440cb9d3ad26a27af33e5

Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells.

Autor: Wang M; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Graner AN; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Knowles B; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA., McRae C; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Fringuello A; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Cell Biology, State University of New York Downstate Health Sciences University, New York, NY 11203, USA., Paucek P; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Gavrilovic M; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Biomedical Sciences, Regis University, Denver, CO 80221, USA.; St Louis University School of Medicine, St. Louis, MO 63104, USA., Redwine M; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Biomedical Sciences, Regis University, Denver, CO 80221, USA., Hanson C; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Biomedical Sciences, Regis University, Denver, CO 80221, USA., Coughlan C; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Grimaldo-Garcia S; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Neuroscience, Middlebury College, Middlebury, VT 05753, USA., Metzger B; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Occupational Therapy, Illinois College, Jacksonville, IL 62650, USA.; Neuroscience, Midwestern University, Glendale, AZ 85308, USA., Bolus V; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Kopper TJ; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Smith M; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Zhou W; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Lenz M; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Occupational Therapy, Illinois College, Jacksonville, IL 62650, USA., Abosch A; Department of Neurosurgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Ojemann S; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Lillehei KO; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Yu X; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Graner MW; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Publikováno v: Neurology international [Neurol Int] 2024 Nov 06; Vol. 16 (6), pp. 1355-1384. Date of Electronic Publication: 2024 Nov 06.

Supplemental LED Lighting Improves Fruit Growth and Yield of Tomato Grown under the Sub-Optimal Lighting Condition of a Building Integrated Rooftop Greenhouse (i-RTG)

Autor: Elisa Appolloni, Ivan Paucek, Giuseppina Pennisi, Gaia Stringari, Xavier Gabarrell Durany, Francesco Orsini, Giorgio Gianquinto

Publikováno v: Horticulturae, Vol 8, Iss 9, p 771 (2022)

The metabolism of a building can be connected to a rooftop greenhouse, exchanging energy, water and CO2 flows, therefore reducing emissions and recycling cultivation inputs. However, integrating a rooftop greenhouse onto a building requires the appli

Externí odkaz: https://doaj.org/article/eaf83a5f9a6d4d50bb32302ea6fb393e

Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

Autor: Josh Lewis Stern, Richard D. Paucek, Franklin W. Huang, Mahmoud Ghandi, Ronald Nwumeh, James C. Costello, Thomas R. Cech

Publikováno v: Cell Reports, Vol 31, Iss 8, Pp - (2020)

Externí odkaz: https://doaj.org/article/da4f6c3a1a9c465285f49876fe953614

Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

Autor: Josh Lewis Stern, Richard D. Paucek, Franklin W. Huang, Mahmoud Ghandi, Ronald Nwumeh, James C. Costello, Thomas R. Cech

Publikováno v: Cell Reports, Vol 21, Iss 13, Pp 3700-3707 (2017)

A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation

Externí odkaz: https://doaj.org/article/c27f6ff038f343f593bbad95d49cc6f2