Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Patxi San Martin"'
Autor:
Guillermo Serrano, Nerea Berastegui, Aintzane Díaz-Mazkiaran, Paula García-Olloqui, Carmen Rodriguez-Res, Sofia Huerga-Dominguez, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Asier Ullate-Agote, Beñat Ariceta, Jose-Maria Lamo-Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Maria Julia Montoro, Maria Díez-Campelo, David Valcarcel, Francisco Solé, Ana Alfonso-Pierola, Idoia Ochoa, Felipe Prósper, Teresa Ezponda, Mikel Hernaez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34+ progenitors from del(5q) MD
Externí odkaz:
https://doaj.org/article/91536052d5734ebda987ce77dddb892b
Autor:
Leyre Ayerra, Miguel Angel Abellanas, Leyre Basurco, Ibon Tamayo, Enrique Conde, Adriana Tavira, Amaya Trigo, Clara Vidaurre, Amaia Vilas, Patxi San Martin-Uriz, Esther Luquin, Pedro Clavero, Elisa Mengual, Sandra Hervás-Stubbs, Maria S. Aymerich
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Since modulation of neuroinflammat
Externí odkaz:
https://doaj.org/article/5fe591e290234b398623ebc343d1cb63
Autor:
Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing
Externí odkaz:
https://doaj.org/article/5a52f5ed769d4553afa3673e2f1e7052
Autor:
Cristina Calviño, Candela Ceballos, Ana Alfonso, Patricia Jauregui, Maria E. Calleja-Cervantes, Patxi San Martin-Uriz, Paula Rodriguez-Marquez, Angel Martin-Mallo, Elena Iglesias, Gloria Abizanda, Saray Rodriguez-Diaz, Rebeca Martinez-Turrillas, Jorge Illarramendi, Maria C. Viguria, Margarita Redondo, Jose Rifon, Sara Villar, Juan J. Lasarte, Susana Inoges, Ascension Lopez-Diaz de Cerio, Mikel Hernaez, Felipe Prosper, Juan R. Rodriguez-Madoz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite the potential of CAR-T therapies for hematological malignancies, their efficacy in patients with relapse and refractory Acute Myeloid Leukemia has been limited. The aim of our study has been to develop and manufacture a CAR-T cell product tha
Externí odkaz:
https://doaj.org/article/f8de5ca01ff34ed9b089165eb0725060
Autor:
Rebeca Martinez-Turrillas, Angel Martin-Mallo, Saray Rodriguez-Diaz, Natalia Zapata-Linares, Paula Rodriguez-Marquez, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, María E. Calleja-Cervantes, Eduardo Salido, Felipe Prosper, Juan R. Rodriguez-Madoz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 137-146 (2022)
Genome-editing strategies, especially CRISPR-Cas9 systems, have substantially increased the efficiency of innovative therapeutic approaches for monogenic diseases such as primary hyperoxalurias (PHs). We have previously demonstrated that inhibition o
Externí odkaz:
https://doaj.org/article/bd677a9b29c243f29edb333113c24eef
Autor:
Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso-Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Lamo-Espinosa, Mikel San-Julian, Tamara Jiménez-Solas, Felix Lopez, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, David Gomez-Cabrero, Maria Diez-Campelo, David Valcarcel, Mikel Hernaez, Juan P Romero, Felipe Prosper
Publikováno v:
eLife, Vol 12 (2023)
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regu
Externí odkaz:
https://doaj.org/article/3e9c063b4a474f658aaf2538b69955f6
Autor:
Jin Ye, Isabel A. Calvo, Itziar Cenzano, Amaia Vilas, Xabier Martinez-de-Morentin, Miren Lasaga, Diego Alignani, Bruno Paiva, Ana C. Viñado, Patxi San Martin-Uriz, Juan P. Romero, Delia Quilez Agreda, Marta Miñana Barrios, Ignacio Sancho-González, Gabriele Todisco, Luca Malcovati, Nuria Planell, Borja Saez, Jesper N. Tegner, Felipe Prosper, David Gomez-Cabrero
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104225- (2022)
Summary: Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory microenvironment. Here, we develop a tailored bioinformatic pipeline to integrate publ
Externí odkaz:
https://doaj.org/article/ccde1bb022e24ec1a1f2e788e69807b2
Autor:
Miguel Angel Abellanas, Marta Zamarbide, Leyre Basurco, Esther Luquin, Marta Garcia-Granero, Pedro Clavero, Patxi San Martin-Uriz, Amaia Vilas, Elisa Mengual, Sandra Hervas-Stubbs, Maria S. Aymerich
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Inflammation is a critical process for the progression of neuronal death in neurodegenerative disorders. Microglia play a central role in neuroinflammation and may affect neuron vulnerability. Next generation sequencing has shown
Externí odkaz:
https://doaj.org/article/24e6e6f40874469fbaaf6d289784e8f1
Autor:
Patxi San Martin-Uriz, Salvador Mirete, Pedro J Alcolea, Manuel J Gomez, Ricardo Amils, Jose E Gonzalez-Pastor
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95041 (2014)
Acidiphilium spp. are conspicuous dwellers of acidic, metal-rich environments. Indeed, they are among the most metal-resistant organisms; yet little is known about the mechanisms behind the metal tolerance in this genus. Acidiphilium sp. PM is an env
Externí odkaz:
https://doaj.org/article/020e5dc2a3ed47729236e1cdf1a8bd11
Autor:
Leyre Basurco, Miguel Angel Abellanas, Leyre Ayerra, Enrique Conde, Rodrigo Vinueza‐Gavilanes, Esther Luquin, Africa Vales, Amaya Vilas, Patxi San Martin‐Uriz, Ibon Tamayo, Marta M. Alonso, Mikel Hernaez, Gloria Gonzalez‐Aseguinolaza, Pedro Clavero, Elisa Mengual, Montserrat Arrasate, Sandra Hervás‐Stubbs, Maria S. Aymerich
Publikováno v:
Glia. 71:571-587
Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro-inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d219188ae752b05d2d9e7b086b917e
https://doi.org/10.1002/glia.24295
https://doi.org/10.1002/glia.24295