Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patty Rosten"'
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151584 (2016)
Meis1 is recognized as an important transcriptional regulator in hematopoietic development and is strongly implicated in the pathogenesis of leukemia, both as a Hox transcription factor co-factor and independently. Despite the emerging recognition of
Externí odkaz:
https://doaj.org/article/23f4c0f068454d16932e22c16ecfb4d4
Autor:
Michael Heuser, T. R. Docking, N von Krosigk, L Sanchez Milde, Courteney Lai, Aly Karsan, Patty Rosten, Tobias Maetzig, Gudmundur L. Norddahl, T Lohr, R K Humphries
Publikováno v:
Blood Cancer Journal
Meningioma 1 (MN1) is an independent prognostic marker for normal karyotype acute myeloid leukemia (AML), with high expression linked to all-trans retinoic acid resistance and poor survival. MN1 is also a potent and sufficient oncogene in murine leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed02ebf5cea7ef8b985b5eae41be79e2
https://pubmed.ncbi.nlm.nih.gov/28960191
https://pubmed.ncbi.nlm.nih.gov/28960191
Autor:
Pamela A. Hoodless, Constanze Bonifer, Juan Hou, Peter N. Cockerill, Patty Rosten, C Lo, Keith Humphries, Ping Xiang, Berthold Göttgens, Martin Hirst, Aileen M. Kirkpatrick, Misha Bilenky, Wei Wei
Publikováno v:
Leukemia. 28:433-436
MEIS1 (Myeloid ecotropic viral integration site 1) is a homeodomain transcription factor that cooperates with Hox family proteins in both normal and leukemic hematopoiesis.1 MEIS1 is highly expressed in hematopoietic stem cells (HSCs), and its level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a5916189ffe29d3aabfd0c11b52d62
https://doi.org/10.1038/leu.2013.287
https://doi.org/10.1038/leu.2013.287
Autor:
Keith Humphries, Mickie Bhatia, David S. Allan, Junfeng Ji, Seok-Ho Hong, Patty Rosten, Ruth M. Risueño
Publikováno v:
Stem Cells. 29:736-741
Hox genes encode highly conserved transcription factors that have been implicated in hematopoietic development and self-renewal of hematopoietic stem cells (HSCs) and hematopoietic development. The potency of NUP98-HOXA10hd (NA10) on adult murine bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c0613c88cfb6b98fd79d26eb57a7a0
https://doi.org/10.1002/stem.622
https://doi.org/10.1002/stem.622
Autor:
Harry Chang, Hubert Serve, Silvia Thoene, Samuel Aparicio, Martin Hirst, Tobias Berg, Sherry Lee, Nathalie Schoeler, Patty Rosten, Andrew J. Mungall, R. Keith Humphries, Thomas Oellerich, Damian Yap, Marco A. Marra, Patricia Umlandt, Emilia L. Lim, Misha Bilenky, Randy D. Gascoyne, David Lai, Ryan D. Morin, S.-W. Grace Cheng, Tracee Wee, Courteney Lai, Anisa Salmi, Gregg B. Morin, Lisa Yue
Publikováno v:
Blood. 123(25)
The histone methyltransferase EZH2 is frequently mutated in germinal center-derived diffuse large B-cell lymphoma and follicular lymphoma. To further characterize these EZH2 mutations in lymphomagenesis, we generated a mouse line where EZH2(Y641F) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ef45e6e8d6aa831097e8e57e508672
https://pubmed.ncbi.nlm.nih.gov/24802772
https://pubmed.ncbi.nlm.nih.gov/24802772
Autor:
Gerald Krystal, Jacqueline E Damen, Cheryl D Helgason, Michael Huber, Michael R Hughes, Janet Kalesnikoff, Vivian Lam, Patty Rosten, Mark D Ware, Sandie Yew, R.Keith Humphries
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 31:1007-1010
In 1996 three groups independently cloned a hemopoietic specific, src homology 2-containing inositol 5'-phosphatase which, based on its structure, was called SHIP. More recently, a second more widely expressed SHIP-like protein has been cloned and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29c6fb77afb1a50833f1f40d3eb7c43
https://doi.org/10.1016/s1357-2725(99)00072-2
https://doi.org/10.1016/s1357-2725(99)00072-2
Autor:
Rewa Grewal, R. Keith Humphries, Gerald Krystal, Cheryl D. Helgason, Frank R. Jirik, Anita Borowski, Poul H. Sorensen, Patty Rosten, Jacqueline E. Damen, Suzanne M. Chappel
Publikováno v:
Genes & Development. 12:1610-1620
SHIP is a 145-kDSH2-containinginositol-5-phosphatase widely expressed in hemopoietic cells. It was first identified as a tyrosine phosphoprotein associated with Shc in response to numerous cytokines. SHIP has been implicated in FcγRIIB receptor-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7e582244baa8ffd2a3afb184190718
https://doi.org/10.1101/gad.12.11.1610
https://doi.org/10.1101/gad.12.11.1610
Publikováno v:
Scopus-Elsevier
We recently cloned and sequenced a cDNA encoding a 145-kD protein from the murine hematopoietic cell line B6SUtA, that becomes tyrosine phosphorylated and associated with Shc after cytokine stimulation. Based on its domains and enzymatic activity, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8d39dd899fe39bd74bbdecb87e33a9
https://doi.org/10.1182/blood.v88.8.2833.bloodjournal8882833
https://doi.org/10.1182/blood.v88.8.2833.bloodjournal8882833
Autor:
Gerald Krystal, Philip W. Majerus, Anne Bennett Jefferson, R K Humphries, Ling Liu, Patty Rosten, Jacqueline E. Damen
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1689-1693
A 145-kDa tyrosine-phosphorylated protein that becomes associated with Shc in response to multiple cytokines has been purified from the murine hemopoietic cell line B6SUtA1. Amino acid sequence data were used to clone the cDNA encoding this protein f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb67cf2ad8d5f89b5865dcae65b68da
https://doi.org/10.1073/pnas.93.4.1689
https://doi.org/10.1073/pnas.93.4.1689
Autor:
Christy Brookes, Adrian Wan, Veronique Lecault, James M. Piret, Patty Rosten, Corinne A. Hoesli, Clayton A. Smith, David G. Kent, Carl L. Hansen, Maura Gasparetto, R. Keith Humphries, Sanja Sekulovic, Connie J. Eaves
Publikováno v:
Blood. 118(16)
Achieving high-level expansion of hematopoietic stem cells (HSCs) in vitro will have an important clinical impact in addition to enabling elucidation of their regulation. Here, we couple the ability of engineered NUP98-HOXA10hd expression to stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d2991954aa682252700f9b3b448903
https://pubmed.ncbi.nlm.nih.gov/21865344
https://pubmed.ncbi.nlm.nih.gov/21865344